Protein Tyrosine Phosphatases : : Structure, Signaling and Drug Discovery / / Lalima G. Ahuja.
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of sign...
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Superior document: | Title is part of eBook package: De Gruyter DG Plus eBook-Package 2018 |
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Place / Publishing House: | Berlin ;, Boston : : De Gruyter, , [2018] ©2018 |
Year of Publication: | 2018 |
Language: | English |
Online Access: | |
Physical Description: | 1 online resource (XIV, 282 p.) |
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050 | 4 | |a QP609.P56 |b A44 2018 | |
072 | 7 | |a SCI013020 |2 bisacsh | |
082 | 0 | 4 | |a 572/.68 |2 23 |
100 | 1 | |a Ahuja, Lalima G., |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
245 | 1 | 0 | |a Protein Tyrosine Phosphatases : |b Structure, Signaling and Drug Discovery / |c Lalima G. Ahuja. |
264 | 1 | |a Berlin ; |a Boston : |b De Gruyter, |c [2018] | |
264 | 4 | |c ©2018 | |
300 | |a 1 online resource (XIV, 282 p.) | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
347 | |a text file |b PDF |2 rda | ||
505 | 0 | 0 | |t Frontmatter -- |t Preface -- |t About The Author -- |t Contents -- |t 1.Tyrosine Phosphorylation In Cell Signaling: Discovery And Beyond -- |t 2.Protein Phosphatases: Classification And Domain Architecture -- |t 3.Protein Tyrosine Phosphatases: Molecular Structure And Mechanism -- |t 4.The Receptor Protein Tyrosine Phosphatases: Structure And Function -- |t 5.The Double-Domain Receptor Protein Tyrosine Phosphatases -- |t 6 The Non-Receptor Protein Tyrosine Phosphatases: Part I -- |t 7.The Non-Receptor Protein Tyrosine Phosphatases: Part Ii -- |t 8.Protein Tyrosine Phosphatases: Strategies For Drug Development -- |t Index |
506 | 0 | |a restricted access |u http://purl.org/coar/access_right/c_16ec |f online access with authorization |2 star | |
520 | |a Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes. | ||
538 | |a Mode of access: Internet via World Wide Web. | ||
546 | |a In English. | ||
588 | 0 | |a Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2021) | |
650 | 0 | |a Protein-tyrosine phosphatase. | |
650 | 4 | |a Biochemie. | |
650 | 4 | |a Medizinische Chemie. | |
650 | 4 | |a Proteintyrosinphosphatase. | |
650 | 4 | |a Signalproteine. | |
650 | 4 | |a Wirkstoffdesign. | |
650 | 7 | |a SCIENCE / Chemistry / Clinical. |2 bisacsh | |
653 | |a Biochemistry. | ||
653 | |a Drug Design. | ||
653 | |a Medicinal Chemistry. | ||
653 | |a Protein Tyrosine Phosphatase. | ||
653 | |a Signalling Proteins. | ||
773 | 0 | 8 | |i Title is part of eBook package: |d De Gruyter |t DG Plus eBook-Package 2018 |z 9783110719550 |
773 | 0 | 8 | |i Title is part of eBook package: |d De Gruyter |t EBOOK PACKAGE COMPLETE 2018 English |z 9783110604252 |
773 | 0 | 8 | |i Title is part of eBook package: |d De Gruyter |t EBOOK PACKAGE COMPLETE 2018 |z 9783110603255 |o ZDB-23-DGG |
773 | 0 | 8 | |i Title is part of eBook package: |d De Gruyter |t EBOOK PACKAGE Physics, Chem., Mat.Sc, Geosc 2018 English |z 9783110604221 |
773 | 0 | 8 | |i Title is part of eBook package: |d De Gruyter |t EBOOK PACKAGE Physics, Chemistry, Materials Sc, Geosc 2018 |z 9783110603224 |o ZDB-23-DPC |
776 | 0 | |c EPUB |z 9783110421842 | |
776 | 0 | |c print |z 9783110426434 | |
856 | 4 | 0 | |u https://doi.org/10.1515/9783110421774 |
856 | 4 | 0 | |u https://www.degruyter.com/isbn/9783110421774 |
856 | 4 | 2 | |3 Cover |u https://www.degruyter.com/cover/covers/9783110421774.jpg |
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