Animal Cell Biotechnology : : In Biologics Production / / ed. by Roland Wagner, Hansjörg Hauser.

• Superior document: Title is part of eBook package: De Gruyter DGBA Backlist Complete English Language 2000-2014 PART1
• MitwirkendeR: Altamirano, Claudia,; Ausländer, David,; Baumann, Martina,; Bennun, Sandra V.,; Berrios, Julio,; Betenbaugh, Michael J.,; Blake, Emily,; Bollati-Fogolín, Mariela,; Borth, Nicole,; Brinkrolf, Karina,; Butler, Michael,; Ceaglio, Natalia,; Chung, Andrew,; Conley, Lynn,; Dirks, Wilhelm G.,; Drexler, Hans G.,; Eisenkraetzer, Detlef,; Etcheverrigaray, Marina,; Florin, Lore,; Fontes, Nuno,; Frandsen, Torben P.,; Fussenegger, Martin,; Goesmann, Alexander,; Hackl, Matthias,; Hauser, Hansjörg,; Heffner, Kelley M.,; Henning von Horsten, Hans,; Hoffrogge, Raimund,; Hong Que, Amy,; Hu, Weiwei,; Janakiraman, Vijay,; Jordan, Ingo,; Kaufmann, Hitto,; Kratje, Ricardo,; Kruse, Natascha,; Lee, Kyoungho,; Lipps, Christoph,; MacLeod, Roderick A. F.,; May, Tobias,; Müller, Dethardt,; Noll, Thomas,; Oggero, Marcos,; Omasa, Takeshi,; Pühler, Alfred,; Rasmussen, Sören K.,; Rebmann, Balder,; Ryll, Thomas,; Sandig, Volker,; Smelko, John Paul,; Spencer, Shawal,; Tauch, Andreas,; Tayi, Venkata,; Tolstrup, Anne B.,; Uphoff, Cord C.,; Vergara, Mauricio,; Vogel, Jens H.,; Wagner, Roland,; Wang, Yang,; Weber, Wilfried,; Westoby, Matthew,; Wiltberger, Kelly,; Winkler, Karsten,; Wirth, Dagmar,; Wurm, Florian M.,; Zhang, Ruoheng,; Ziyi Kan, Steven,; Zurbriggen, Matias,; van Hoogevest, Peter,
• HerausgeberIn: Hauser, Hansjörg,; Wagner, Roland,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2014]; ©2014
• Year of Publication: 2014
• Language: English
• Physical Description: 1 online resource (702 p.)

This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell l...

Table of Contents

• Frontmatter
• Preface
• Contents
• List of Contributing Authors
• 1. Introduction
• 1.1 Industrial Use and Perspectives of Animal Cell Culture
• 2. Cell Lines
• 2.1 Generation of Cell Lines and Biotechnological Applications
• 2.2 CHO History, CHO Evolution and CHO Genomics – an Unsolvable Enigma?
• 2.3 Cell Lines for Vaccine Production
• 2.4 Cell Line Monitoring: Molecular Cytogenetic Characterization
• 2.5 Quality Control Essentials in Human Cell Culture: Cell Line Cross-contamination and Microbiological Infections
• 3. Genetic Engineering of Cells
• 3.1 Cell Line Evolution and Engineering
• 3.2 Chromosome Rearrangements and Gene Amplification
• 3.3 Synthetic Biology Principles for Engineering Mammalian Designer Cells
• 3.4 Rational Approaches for Transgene Expression: Targeted Integration and Episomal Maintenance
• 3.5 Manipulation of Cell Growth, Metabolism and Product Quality Attributes
• 4. Engineering of the Product
• 4.1 Control of Biotheraputics Glycosylation
• 4.2 Manufacturing of Complex Biotherapeutic Protein Products: Medical Need and Rational for Monoclonal Antibody Mixtures, Multispecific Formats, and Fc-fusion Proteins
• 5. Basic Aspects of Animal Cell Cultivation
• 5.1 Physiology and Metabolism of Animal Cells for Production
• 5.2 Functional -Omics for Cell Lines and Processes: The -Omics Technologies on the Example of CHO Cells
• 5.3 Nutrient Media for Cell Culture Technology
• 6. Upstream and Downstream Process Technology
• 6.1 Bioreactors for Animal Cell Culture
• 6.2 High Cell Density Cultivation Process
• 6.3 Industrial Cell Culture Process Scale-up Strategies and Considerations
• 6.4 Extraction and Purification of Biologics from Cell Culture: Monoclonal Antibody Downstream Processing
• 7. Monitoring and Control of Processes and Products
• 7.1 Concepts and Technologies for Advanced Process Monitoring and Control
• 7.2 Analytical Techniques and Quality Control of Protein Therapeutics
• 7.3 Process Characterization for Upstream and Downstream Process Development
• 8. Pharmaceutical Aspects of Biologics from Animal Cell Culture Processes
• 8.1 Spatiotemporally Controlled Delivery of Biopharmaceuticals
• Index