Kernicterus : : Report based on a symposium held at the IX International Congress of Paediatrics / / ed. by Andrew Sass-Kortsak.
The IXth International Congress of Paediatrics selected Kernicterus as one of the major topics for discussion in recognition of the significant advances made in medical knowledge of this problem during the past decades. The discussion, carried on by an international panel of leading clinicians and b...
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Place / Publishing House: | Toronto : : University of Toronto Press, , [2020] ©1961 |
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Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / ed. by Andrew Sass-Kortsak. Toronto : University of Toronto Press, [2020] ©1961 1 online resource (240 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Heritage Frontmatter -- PREFACE -- CONTENTS -- CONTRIBUTORS -- PANEL A . KERNICTERUS OF PREMATURITY: INCIDENCE AND AETIOLOGICAL FACTORS -- Introduction -- The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies -- Peak Levels of Serum Bilirubin in Normal Premature Infants -- Experience with Kernicterus in Premature Infants -- The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity -- Physiological Jaundice Re-examined -- PANEL B. FACTORS INFLUENCING THE LIFE SPAN OF THE RED BLOOD CELL -- Introduction -- Physiological Mechanisms of Red Blood Cell Destruction -- The Life Span of Erythrocytes in the Newborn -- The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia -- Peculiarities of Erythrocytes of the Newborn -- Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants -- A Possible Effect of Vitamin K3 on Erythrocyte Metabolism -- The Destruction of Red Cells by Antibodies -- The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility -- PANEL C. THE METABOLISM AND EXCRETION OF BILIRUBIN -- Introduction -- The Mechanism of Glucuronide Formation -- Studies of Glucuronide Formation -- Bilirubin Sulfate -- The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation -- Factors Influencing the Synthesis of Direct Reacting Bilirubin -- Familial Defect of Glucuronidation: in vivo Studies -- Conjugated Hyperbilirubinaemia : A Transport -- Bilirubin Metabolism in the Foetus -- Glucuronide Formation in Pre-Natal and Neonatal Life -- Foetal and Neonatal Development of the Glucuronide-Conjugating System -- Conclusion -- PANEL D. THE PATHOLOGY OF KERNICTERUS AND THE CYTOTOXICITY OF BILIRUBIN -- Introduction -- Pathology of Human Kernicterus -- Kernicterus in Gunn's Strain of Rats -- The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants -- Experimental Studies on the Toxicity of Bilirubin -- Toxicity of Haeme Pigments in Different Test Systems -- Bilirubin Encephalopathy-Cytotoxicity -- The Mode of Action of Bilirubin on Mitochondria -- PANEL E. FACTORS INFLUENCING THE DISTRIBUTION OF BILIBUBIN IN THE BODY -- Introduction -- The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period -- Factors Influencing the Binding of Bilirubin by Albumin -- The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats -- The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies restricted access http://purl.org/coar/access_right/c_16ec online access with authorization star The IXth International Congress of Paediatrics selected Kernicterus as one of the major topics for discussion in recognition of the significant advances made in medical knowledge of this problem during the past decades. The discussion, carried on by an international panel of leading clinicians and basic scientists, was lively and informative. Since the Congress the participants have prepared their papers for presentation in book form, providing illustrations and references, and taking account of the newest material pertaining to the subject. In this volume emphasis is laid on the examination of the various etiological factors which may lead to the development of hyperbilirubinemia, and of the factors which then may facilitate the development of secondary brain damage. There is a collaborative effort to present material which will help physicians in the prevention of this condition and in the improvement of their methods of treatment of it. The introductory panel examines the incidence and clinical course of Kernicterus in premature infants and especially the factors, other than immune haemolytic disease, which many lead to the development of it. Other papers provide statistical material on the incidence of Kernicterus of prematurity, re-evaluate concepts of physiological jaundice, report studies of the question of whether hyperbilirubinemia is premature could lead to neurological sequelae in later life, outline the factors which may influence the life span of the red blood cells in the newborn, describe the distribution and the metabolism of bilirubin in the body and the mechanism of its excretion, and give a pathology of Kernicterus in both humans and animals. It is established that the blood levels of bilirubin cannot be relied upon exclusively to indicate the degree of danger of development of Kernicterus. Mode of access: Internet via World Wide Web. In English. Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2021) Kernicterus. MEDICAL / Pediatrics. bisacsh Abrahamov, Abraham, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Arias, Irwin M., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Billing, Barbara H., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Blanc, William A., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Brown, Audrey K., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Chown, Bruce, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Claireaux, Albert E., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Crosse, V. Mary, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Day, Richard, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Dutton, Geoffrey J., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Dutton, Jeoffrey J., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Ernster, Lars, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Freedman, Alfred M., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Grewar, David A. I., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Harris, Ruth C., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Hsia, David Yi-Yung, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Jandl, James H., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Johnson, Lois M., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Kaplan, Eugene, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Lathe, Grant H., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Lucey, Jerold F., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Odell, Gerard B., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Polaček, Karel, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Rozdilsky, Bohdan, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Sass-Kortsak, Andrew, editor. edt http://id.loc.gov/vocabulary/relators/edt Schmid, Rudi, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Sidbury, James B., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Silverman, William A., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Vietti, Teresa J., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Waters, William J., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Waters, William, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Zetterström, Rolf, contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Zinkham, William H., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Zuelzer, Wolf W., contributor. ctb https://id.loc.gov/vocabulary/relators/ctb Title is part of eBook package: De Gruyter University of Toronto Press eBook-Package Archive 1933-1999 9783110490947 https://doi.org/10.3138/9781487583491 https://www.degruyter.com/isbn/9781487583491 Cover https://www.degruyter.com/cover/covers/9781487583491.jpg |
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English |
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Abrahamov, Abraham, Abrahamov, Abraham, Arias, Irwin M., Arias, Irwin M., Billing, Barbara H., Billing, Barbara H., Blanc, William A., Blanc, William A., Brown, Audrey K., Brown, Audrey K., Chown, Bruce, Chown, Bruce, Claireaux, Albert E., Claireaux, Albert E., Crosse, V. Mary, Crosse, V. Mary, Day, Richard, Day, Richard, Dutton, Geoffrey J., Dutton, Geoffrey J., Dutton, Jeoffrey J., Dutton, Jeoffrey J., Ernster, Lars, Ernster, Lars, Freedman, Alfred M., Freedman, Alfred M., Grewar, David A. I., Grewar, David A. I., Harris, Ruth C., Harris, Ruth C., Hsia, David Yi-Yung, Hsia, David Yi-Yung, Jandl, James H., Jandl, James H., Johnson, Lois M., Johnson, Lois M., Kaplan, Eugene, Kaplan, Eugene, Lathe, Grant H., Lathe, Grant H., Lucey, Jerold F., Lucey, Jerold F., Odell, Gerard B., Odell, Gerard B., Polaček, Karel, Polaček, Karel, Rozdilsky, Bohdan, Rozdilsky, Bohdan, Sass-Kortsak, Andrew, Sass-Kortsak, Andrew, Schmid, Rudi, Schmid, Rudi, Sidbury, James B., Sidbury, James B., Silverman, William A., Silverman, William A., Vietti, Teresa J., Vietti, Teresa J., Waters, William J., Waters, William J., Waters, William, Waters, William, Zetterström, Rolf, Zetterström, Rolf, Zinkham, William H., Zinkham, William H., Zuelzer, Wolf W., Zuelzer, Wolf W., |
author_facet |
Abrahamov, Abraham, Abrahamov, Abraham, Arias, Irwin M., Arias, Irwin M., Billing, Barbara H., Billing, Barbara H., Blanc, William A., Blanc, William A., Brown, Audrey K., Brown, Audrey K., Chown, Bruce, Chown, Bruce, Claireaux, Albert E., Claireaux, Albert E., Crosse, V. Mary, Crosse, V. Mary, Day, Richard, Day, Richard, Dutton, Geoffrey J., Dutton, Geoffrey J., Dutton, Jeoffrey J., Dutton, Jeoffrey J., Ernster, Lars, Ernster, Lars, Freedman, Alfred M., Freedman, Alfred M., Grewar, David A. I., Grewar, David A. I., Harris, Ruth C., Harris, Ruth C., Hsia, David Yi-Yung, Hsia, David Yi-Yung, Jandl, James H., Jandl, James H., Johnson, Lois M., Johnson, Lois M., Kaplan, Eugene, Kaplan, Eugene, Lathe, Grant H., Lathe, Grant H., Lucey, Jerold F., Lucey, Jerold F., Odell, Gerard B., Odell, Gerard B., Polaček, Karel, Polaček, Karel, Rozdilsky, Bohdan, Rozdilsky, Bohdan, Sass-Kortsak, Andrew, Sass-Kortsak, Andrew, Schmid, Rudi, Schmid, Rudi, Sidbury, James B., Sidbury, James B., Silverman, William A., Silverman, William A., Vietti, Teresa J., Vietti, Teresa J., Waters, William J., Waters, William J., Waters, William, Waters, William, Zetterström, Rolf, Zetterström, Rolf, Zinkham, William H., Zinkham, William H., Zuelzer, Wolf W., Zuelzer, Wolf W., |
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author_sort |
Abrahamov, Abraham, |
title |
Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / |
spellingShingle |
Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / Heritage Frontmatter -- PREFACE -- CONTENTS -- CONTRIBUTORS -- PANEL A . KERNICTERUS OF PREMATURITY: INCIDENCE AND AETIOLOGICAL FACTORS -- Introduction -- The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies -- Peak Levels of Serum Bilirubin in Normal Premature Infants -- Experience with Kernicterus in Premature Infants -- The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity -- Physiological Jaundice Re-examined -- PANEL B. FACTORS INFLUENCING THE LIFE SPAN OF THE RED BLOOD CELL -- Physiological Mechanisms of Red Blood Cell Destruction -- The Life Span of Erythrocytes in the Newborn -- The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia -- Peculiarities of Erythrocytes of the Newborn -- Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants -- A Possible Effect of Vitamin K3 on Erythrocyte Metabolism -- The Destruction of Red Cells by Antibodies -- The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility -- PANEL C. THE METABOLISM AND EXCRETION OF BILIRUBIN -- The Mechanism of Glucuronide Formation -- Studies of Glucuronide Formation -- Bilirubin Sulfate -- The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation -- Factors Influencing the Synthesis of Direct Reacting Bilirubin -- Familial Defect of Glucuronidation: in vivo Studies -- Conjugated Hyperbilirubinaemia : A Transport -- Bilirubin Metabolism in the Foetus -- Glucuronide Formation in Pre-Natal and Neonatal Life -- Foetal and Neonatal Development of the Glucuronide-Conjugating System -- Conclusion -- PANEL D. THE PATHOLOGY OF KERNICTERUS AND THE CYTOTOXICITY OF BILIRUBIN -- Pathology of Human Kernicterus -- Kernicterus in Gunn's Strain of Rats -- The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants -- Experimental Studies on the Toxicity of Bilirubin -- Toxicity of Haeme Pigments in Different Test Systems -- Bilirubin Encephalopathy-Cytotoxicity -- The Mode of Action of Bilirubin on Mitochondria -- PANEL E. FACTORS INFLUENCING THE DISTRIBUTION OF BILIBUBIN IN THE BODY -- The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period -- Factors Influencing the Binding of Bilirubin by Albumin -- The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats -- The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies |
title_sub |
Report based on a symposium held at the IX International Congress of Paediatrics / |
title_full |
Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / ed. by Andrew Sass-Kortsak. |
title_fullStr |
Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / ed. by Andrew Sass-Kortsak. |
title_full_unstemmed |
Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / ed. by Andrew Sass-Kortsak. |
title_auth |
Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / |
title_alt |
Frontmatter -- PREFACE -- CONTENTS -- CONTRIBUTORS -- PANEL A . KERNICTERUS OF PREMATURITY: INCIDENCE AND AETIOLOGICAL FACTORS -- Introduction -- The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies -- Peak Levels of Serum Bilirubin in Normal Premature Infants -- Experience with Kernicterus in Premature Infants -- The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity -- Physiological Jaundice Re-examined -- PANEL B. FACTORS INFLUENCING THE LIFE SPAN OF THE RED BLOOD CELL -- Physiological Mechanisms of Red Blood Cell Destruction -- The Life Span of Erythrocytes in the Newborn -- The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia -- Peculiarities of Erythrocytes of the Newborn -- Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants -- A Possible Effect of Vitamin K3 on Erythrocyte Metabolism -- The Destruction of Red Cells by Antibodies -- The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility -- PANEL C. THE METABOLISM AND EXCRETION OF BILIRUBIN -- The Mechanism of Glucuronide Formation -- Studies of Glucuronide Formation -- Bilirubin Sulfate -- The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation -- Factors Influencing the Synthesis of Direct Reacting Bilirubin -- Familial Defect of Glucuronidation: in vivo Studies -- Conjugated Hyperbilirubinaemia : A Transport -- Bilirubin Metabolism in the Foetus -- Glucuronide Formation in Pre-Natal and Neonatal Life -- Foetal and Neonatal Development of the Glucuronide-Conjugating System -- Conclusion -- PANEL D. THE PATHOLOGY OF KERNICTERUS AND THE CYTOTOXICITY OF BILIRUBIN -- Pathology of Human Kernicterus -- Kernicterus in Gunn's Strain of Rats -- The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants -- Experimental Studies on the Toxicity of Bilirubin -- Toxicity of Haeme Pigments in Different Test Systems -- Bilirubin Encephalopathy-Cytotoxicity -- The Mode of Action of Bilirubin on Mitochondria -- PANEL E. FACTORS INFLUENCING THE DISTRIBUTION OF BILIBUBIN IN THE BODY -- The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period -- Factors Influencing the Binding of Bilirubin by Albumin -- The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats -- The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies |
title_new |
Kernicterus : |
title_sort |
kernicterus : report based on a symposium held at the ix international congress of paediatrics / |
series |
Heritage |
series2 |
Heritage |
publisher |
University of Toronto Press, |
publishDate |
2020 |
physical |
1 online resource (240 p.) |
contents |
Frontmatter -- PREFACE -- CONTENTS -- CONTRIBUTORS -- PANEL A . KERNICTERUS OF PREMATURITY: INCIDENCE AND AETIOLOGICAL FACTORS -- Introduction -- The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies -- Peak Levels of Serum Bilirubin in Normal Premature Infants -- Experience with Kernicterus in Premature Infants -- The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity -- Physiological Jaundice Re-examined -- PANEL B. FACTORS INFLUENCING THE LIFE SPAN OF THE RED BLOOD CELL -- Physiological Mechanisms of Red Blood Cell Destruction -- The Life Span of Erythrocytes in the Newborn -- The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia -- Peculiarities of Erythrocytes of the Newborn -- Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants -- A Possible Effect of Vitamin K3 on Erythrocyte Metabolism -- The Destruction of Red Cells by Antibodies -- The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility -- PANEL C. THE METABOLISM AND EXCRETION OF BILIRUBIN -- The Mechanism of Glucuronide Formation -- Studies of Glucuronide Formation -- Bilirubin Sulfate -- The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation -- Factors Influencing the Synthesis of Direct Reacting Bilirubin -- Familial Defect of Glucuronidation: in vivo Studies -- Conjugated Hyperbilirubinaemia : A Transport -- Bilirubin Metabolism in the Foetus -- Glucuronide Formation in Pre-Natal and Neonatal Life -- Foetal and Neonatal Development of the Glucuronide-Conjugating System -- Conclusion -- PANEL D. THE PATHOLOGY OF KERNICTERUS AND THE CYTOTOXICITY OF BILIRUBIN -- Pathology of Human Kernicterus -- Kernicterus in Gunn's Strain of Rats -- The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants -- Experimental Studies on the Toxicity of Bilirubin -- Toxicity of Haeme Pigments in Different Test Systems -- Bilirubin Encephalopathy-Cytotoxicity -- The Mode of Action of Bilirubin on Mitochondria -- PANEL E. FACTORS INFLUENCING THE DISTRIBUTION OF BILIBUBIN IN THE BODY -- The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period -- Factors Influencing the Binding of Bilirubin by Albumin -- The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats -- The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies |
isbn |
9781487583491 9783110490947 |
url |
https://doi.org/10.3138/9781487583491 https://www.degruyter.com/isbn/9781487583491 https://www.degruyter.com/cover/covers/9781487583491.jpg |
illustrated |
Not Illustrated |
dewey-hundreds |
600 - Technology |
dewey-tens |
610 - Medicine & health |
dewey-ones |
616 - Diseases |
dewey-full |
616.8 |
dewey-sort |
3616.8 |
dewey-raw |
616.8 |
dewey-search |
616.8 |
doi_str_mv |
10.3138/9781487583491 |
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1153458811 |
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Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>10136nam a22010455i 4500</leader><controlfield tag="001">9781487583491</controlfield><controlfield tag="003">DE-B1597</controlfield><controlfield tag="005">20210830012106.0</controlfield><controlfield tag="006">m|||||o||d||||||||</controlfield><controlfield tag="007">cr || ||||||||</controlfield><controlfield tag="008">210830t20201961onc fo d z eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781487583491</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3138/9781487583491</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-B1597)549277</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1153458811</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-B1597</subfield><subfield code="b">eng</subfield><subfield code="c">DE-B1597</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">onc</subfield><subfield code="c">CA-ON</subfield></datafield><datafield tag="072" ind1=" " ind2="7"><subfield code="a">MED069000</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">616.8</subfield><subfield code="2">23</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">Kernicterus :</subfield><subfield code="b">Report based on a symposium held at the IX International Congress of Paediatrics /</subfield><subfield code="c">ed. by Andrew Sass-Kortsak.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Toronto : </subfield><subfield code="b">University of Toronto Press, </subfield><subfield code="c">[2020]</subfield></datafield><datafield tag="264" ind1=" " ind2="4"><subfield code="c">©1961</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (240 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">text file</subfield><subfield code="b">PDF</subfield><subfield code="2">rda</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Heritage</subfield></datafield><datafield tag="505" ind1="0" ind2="0"><subfield code="t">Frontmatter -- </subfield><subfield code="t">PREFACE -- </subfield><subfield code="t">CONTENTS -- </subfield><subfield code="t">CONTRIBUTORS -- </subfield><subfield code="t">PANEL A . KERNICTERUS OF PREMATURITY: INCIDENCE AND AETIOLOGICAL FACTORS -- </subfield><subfield code="t">Introduction -- </subfield><subfield code="t">The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies -- </subfield><subfield code="t">Peak Levels of Serum Bilirubin in Normal Premature Infants -- </subfield><subfield code="t">Experience with Kernicterus in Premature Infants -- </subfield><subfield code="t">The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity -- </subfield><subfield code="t">Physiological Jaundice Re-examined -- </subfield><subfield code="t">PANEL B. FACTORS INFLUENCING THE LIFE SPAN OF THE RED BLOOD CELL -- </subfield><subfield code="t">Introduction -- </subfield><subfield code="t">Physiological Mechanisms of Red Blood Cell Destruction -- </subfield><subfield code="t">The Life Span of Erythrocytes in the Newborn -- </subfield><subfield code="t">The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia -- </subfield><subfield code="t">Peculiarities of Erythrocytes of the Newborn -- </subfield><subfield code="t">Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants -- </subfield><subfield code="t">A Possible Effect of Vitamin K3 on Erythrocyte Metabolism -- </subfield><subfield code="t">The Destruction of Red Cells by Antibodies -- </subfield><subfield code="t">The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility -- </subfield><subfield code="t">PANEL C. THE METABOLISM AND EXCRETION OF BILIRUBIN -- </subfield><subfield code="t">Introduction -- </subfield><subfield code="t">The Mechanism of Glucuronide Formation -- </subfield><subfield code="t">Studies of Glucuronide Formation -- </subfield><subfield code="t">Bilirubin Sulfate -- </subfield><subfield code="t">The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation -- </subfield><subfield code="t">Factors Influencing the Synthesis of Direct Reacting Bilirubin -- </subfield><subfield code="t">Familial Defect of Glucuronidation: in vivo Studies -- </subfield><subfield code="t">Conjugated Hyperbilirubinaemia : A Transport -- </subfield><subfield code="t">Bilirubin Metabolism in the Foetus -- </subfield><subfield code="t">Glucuronide Formation in Pre-Natal and Neonatal Life -- </subfield><subfield code="t">Foetal and Neonatal Development of the Glucuronide-Conjugating System -- </subfield><subfield code="t">Conclusion -- </subfield><subfield code="t">PANEL D. THE PATHOLOGY OF KERNICTERUS AND THE CYTOTOXICITY OF BILIRUBIN -- </subfield><subfield code="t">Introduction -- </subfield><subfield code="t">Pathology of Human Kernicterus -- </subfield><subfield code="t">Kernicterus in Gunn's Strain of Rats -- </subfield><subfield code="t">The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants -- </subfield><subfield code="t">Experimental Studies on the Toxicity of Bilirubin -- </subfield><subfield code="t">Toxicity of Haeme Pigments in Different Test Systems -- </subfield><subfield code="t">Bilirubin Encephalopathy-Cytotoxicity -- </subfield><subfield code="t">The Mode of Action of Bilirubin on Mitochondria -- </subfield><subfield code="t">PANEL E. FACTORS INFLUENCING THE DISTRIBUTION OF BILIBUBIN IN THE BODY -- </subfield><subfield code="t">Introduction -- </subfield><subfield code="t">The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period -- </subfield><subfield code="t">Factors Influencing the Binding of Bilirubin by Albumin -- </subfield><subfield code="t">The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats -- </subfield><subfield code="t">The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies</subfield></datafield><datafield tag="506" ind1="0" ind2=" "><subfield code="a">restricted access</subfield><subfield code="u">http://purl.org/coar/access_right/c_16ec</subfield><subfield code="f">online access with authorization</subfield><subfield code="2">star</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The IXth International Congress of Paediatrics selected Kernicterus as one of the major topics for discussion in recognition of the significant advances made in medical knowledge of this problem during the past decades. The discussion, carried on by an international panel of leading clinicians and basic scientists, was lively and informative. Since the Congress the participants have prepared their papers for presentation in book form, providing illustrations and references, and taking account of the newest material pertaining to the subject. In this volume emphasis is laid on the examination of the various etiological factors which may lead to the development of hyperbilirubinemia, and of the factors which then may facilitate the development of secondary brain damage. There is a collaborative effort to present material which will help physicians in the prevention of this condition and in the improvement of their methods of treatment of it. The introductory panel examines the incidence and clinical course of Kernicterus in premature infants and especially the factors, other than immune haemolytic disease, which many lead to the development of it. Other papers provide statistical material on the incidence of Kernicterus of prematurity, re-evaluate concepts of physiological jaundice, report studies of the question of whether hyperbilirubinemia is premature could lead to neurological sequelae in later life, outline the factors which may influence the life span of the red blood cells in the newborn, describe the distribution and the metabolism of bilirubin in the body and the mechanism of its excretion, and give a pathology of Kernicterus in both humans and animals. It is established that the blood levels of bilirubin cannot be relied upon exclusively to indicate the degree of danger of development of Kernicterus.</subfield></datafield><datafield tag="538" ind1=" " ind2=" "><subfield code="a">Mode of access: Internet via World Wide Web.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">In English.</subfield></datafield><datafield tag="588" ind1="0" ind2=" "><subfield code="a">Description based on online resource; title from PDF title page (publisher's Web site, viewed 30. Aug 2021)</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Kernicterus.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Pediatrics.</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Abrahamov, Abraham, </subfield><subfield code="e">contributor.</subfield><subfield code="4">ctb</subfield><subfield code="4">https://id.loc.gov/vocabulary/relators/ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Arias, Irwin M., </subfield><subfield code="e">contributor.</subfield><subfield code="4">ctb</subfield><subfield code="4">https://id.loc.gov/vocabulary/relators/ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Billing, Barbara H., </subfield><subfield code="e">contributor.</subfield><subfield code="4">ctb</subfield><subfield code="4">https://id.loc.gov/vocabulary/relators/ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Blanc, William A., </subfield><subfield code="e">contributor.</subfield><subfield code="4">ctb</subfield><subfield code="4">https://id.loc.gov/vocabulary/relators/ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brown, Audrey K., </subfield><subfield code="e">contributor.</subfield><subfield code="4">ctb</subfield><subfield code="4">https://id.loc.gov/vocabulary/relators/ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chown, Bruce, </subfield><subfield code="e">contributor.</subfield><subfield code="4">ctb</subfield><subfield code="4">https://id.loc.gov/vocabulary/relators/ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Claireaux, Albert E., </subfield><subfield code="e">contributor.</subfield><subfield code="4">ctb</subfield><subfield code="4">https://id.loc.gov/vocabulary/relators/ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crosse, V. 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