Kernicterus : : Report based on a symposium held at the IX International Congress of Paediatrics / / ed. by Andrew Sass-Kortsak.

• Superior document: Title is part of eBook package: De Gruyter University of Toronto Press eBook-Package Archive 1933-1999
• MitwirkendeR: Abrahamov, Abraham,; Arias, Irwin M.,; Billing, Barbara H.,; Blanc, William A.,; Brown, Audrey K.,; Chown, Bruce,; Claireaux, Albert E.,; Crosse, V. Mary,; Day, Richard,; Dutton, Geoffrey J.,; Dutton, Jeoffrey J.,; Ernster, Lars,; Freedman, Alfred M.,; Grewar, David A. I.,; Harris, Ruth C.,; Hsia, David Yi-Yung,; Jandl, James H.,; Johnson, Lois M.,; Kaplan, Eugene,; Lathe, Grant H.,; Lucey, Jerold F.,; Odell, Gerard B.,; Polaček, Karel,; Rozdilsky, Bohdan,; Schmid, Rudi,; Sidbury, James B.,; Silverman, William A.,; Vietti, Teresa J.,; Waters, William J.,; Waters, William,; Zetterström, Rolf,; Zinkham, William H.,; Zuelzer, Wolf W.,
• HerausgeberIn: Sass-Kortsak, Andrew,
• Place / Publishing House: Toronto : : University of Toronto Press, , [2020]; ©1961
• Year of Publication: 2020
• Language: English
• Series: Heritage
• Physical Description: 1 online resource (240 p.)

The IXth International Congress of Paediatrics selected Kernicterus as one of the major topics for discussion in recognition of the significant advances made in medical knowledge of this problem during the past decades. The discussion, carried on by an international panel of leading clinicians and basic scientists, was lively and informative. Since the Congress the participants have prepared their papers for presentation in book form, providing illustrations and references, and taking account of the newest material pertaining to the subject. In this volume emphasis is laid on the examination of the various etiological factors which may lead to the development of hyperbilirubinemia, and of the factors which then may facilitate the development of secondary brain damage. There is a collaborative effort to present material which will help physicians in the prevention of this condition and in the improvement of their methods of treatment of it. The introductory panel examines the incidence and clinical course of Kernicterus in premature infants and especially the factors, other than immune haemolytic disease, which many lead to the development of it. Other papers provide statistical material on the incidence of Kernicterus of prematurity, re-evaluate concepts of physiological jaundice, report studies of the question of whether hyperbilirubinemia is premature could lead to neurological sequelae in later life, outline the factors which may influence the life span of the red blood cells in the newborn, describe the distribution and the metabolism of bilirubin in the body and the mechanism of its excretion, and give a pathology of Kernicterus in both humans and animals. It is established that the blood levels of bilirubin cannot be relied upon exclusively to indicate the degree of danger of development of Kernicterus.

Table of Contents

Frontmatter -- PREFACE -- CONTENTS -- CONTRIBUTORS -- PANEL A . KERNICTERUS OF PREMATURITY: INCIDENCE AND AETIOLOGICAL FACTORS -- Introduction -- The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies -- Peak Levels of Serum Bilirubin in Normal Premature Infants -- Experience with Kernicterus in Premature Infants -- The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity -- Physiological Jaundice Re-examined -- PANEL B. FACTORS INFLUENCING THE LIFE SPAN OF THE RED BLOOD CELL -- Introduction -- Physiological Mechanisms of Red Blood Cell Destruction -- The Life Span of Erythrocytes in the Newborn -- The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia -- Peculiarities of Erythrocytes of the Newborn -- Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants -- A Possible Effect of Vitamin K3 on Erythrocyte Metabolism -- The Destruction of Red Cells by Antibodies -- The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility -- PANEL C. THE METABOLISM AND EXCRETION OF BILIRUBIN -- Introduction -- The Mechanism of Glucuronide Formation -- Studies of Glucuronide Formation -- Bilirubin Sulfate -- The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation -- Factors Influencing the Synthesis of Direct Reacting Bilirubin -- Familial Defect of Glucuronidation: in vivo Studies -- Conjugated Hyperbilirubinaemia : A Transport -- Bilirubin Metabolism in the Foetus -- Glucuronide Formation in Pre-Natal and Neonatal Life -- Foetal and Neonatal Development of the Glucuronide-Conjugating System -- Conclusion -- PANEL D. THE PATHOLOGY OF KERNICTERUS AND THE CYTOTOXICITY OF BILIRUBIN -- Introduction -- Pathology of Human Kernicterus -- Kernicterus in Gunn's Strain of Rats -- The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants -- Experimental Studies on the Toxicity of Bilirubin -- Toxicity of Haeme Pigments in Different Test Systems -- Bilirubin Encephalopathy-Cytotoxicity -- The Mode of Action of Bilirubin on Mitochondria -- PANEL E. FACTORS INFLUENCING THE DISTRIBUTION OF BILIBUBIN IN THE BODY -- Introduction -- The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period -- Factors Influencing the Binding of Bilirubin by Albumin -- The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats -- The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies