Biopharmaceutics modeling and simulations : theory, practice, methods, and applications / / Kiyohiko Sugano.
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| Year of Publication: | 2012 |
| Language: | English |
| Online Access: | |
| Physical Description: | xxxv, 483 p. :; ill. |
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Table of Contents:
- Introduction
- Theoretical framework I : solubility
- Theoretical framework II : dissolution
- Theoretical framework III : biological membrane permeation
- Theoretical framework IV : gastrointestinal transit models and integration
- Physiology of gastrointestinal tract and other administration sites in humans and animals
- Drug parameters
- Validation of mechanistic models
- Bioequivalence and biopharmaceutical classification system
- Dose and particle size dependency
- Enabling formulations
- Food effect
- Biopharmaceutical modeling for miscellaneous cases
- Intestinal transporters
- Strategy in drug discovery and development
- Epistemology of biopharmaceutical modeling and good simulation practice.