Computational Physiology : : Simula Summer School 2022 Student Reports.

• Superior document: Simula SpringerBriefs on Computing Series ; v.13
• Author: McCabe, Kimberly J.
• Place / Publishing House: Cham : : Springer,, 2023.; ©2023.
• Year of Publication: 2023
• Edition: 1st ed.
• Language: English
• Series: Simula SpringerBriefs on Computing Series
• Physical Description: 1 online resource (118 pages)

Table of Contents

• Intro
• Preface
• Acknowledgements
• Contents
• Chapter 1 An Automated Cardiac Constitutive Modelling Framework with Evolutionary Strain Energy Functions
• 1.1 Introduction
• 1.2 Methods
• 1.2.1 Basic Principles of Hyperelastic Continuum Mechanics
• 1.2.2 Representation of the Strain-Energy Functions as Function Trees
• 1.2.3 Fitting the Strain-Energy Functions to Experimental Data
• 1.2.3.1 Experimental Data under Consideration
• 1.2.3.2 Fitting to the Experimental Data
• 1.2.4 Evolutionary Symbolic Regression Algorithm
• 1.2.4.1 Setup and Initialisation
• 1.2.4.2 Mutation and Mating of Strain-Energy Functions
• 1.2.4.3 Scoring Fitness of Strain-Energy Functions
• 1.3 Results
• 1.3.1 Trial 1: SEF Describing the Shear Data
• 1.3.2 Trial 2: SEF Describing the Shear and Biaxial Data
• 1.4 Discussion
• 1.5 Conclusions
• References
• Chapter 2 Electromechanical In Silico Testing Alters Predicted Drug-Induced Risk to Develop Torsade de Pointes
• 2.1 Introduction
• 2.2 Methods
• 2.2.1 Drug Implementation
• 2.2.2 SimCardEMS Simulations
• 2.2.3 Evaluation
• 2.3 Results
• 2.3.1 Action Potential Duration
• 2.3.2 ElectromechanicalWindow
• 2.3.3 Maximum Active Tension
• 2.3.4 In Silico and in Vitro TdP Risk Classifications
• 2.4 Conclusions
• References
• Chapter 3 In silico Investigation of Sex-Specific Osteoarthritis in Human Articular Chondrocytes
• 3.1 Introduction
• 3.2 Methods
• 3.2.1 Modeling Ionic Changes Induced by Osteoarthritis in Male and Female Chondrocytes
• 3.2.2 Generation of a Population of Models
• 3.2.3 Model Parameter Sensitivity Analysis
• 3.3 Results
• 3.3.1 Modeling the Impact of Sex-Specific OA on Resting Membrane Potential
• 3.3.2 Population of Models
• 3.3.3 Parameter Sensitivity Analysis
• 3.3.4 Inhibiting INaK Restores Normal Resting Membrane Potential in OA Chondrocytes.
• 3.4 Discussion
• 3.5 Conclusions
• References
• Chapter 4 Recapitulating Functional Heterogeneity in Electrophysiologically Active Tissues
• 4.1 Introduction
• 4.2 Methods
• 4.2.1 Cardiomyocytes
• 4.2.2 Islet β-cells
• 4.3 Results
• 4.3.1 Cardiomyocyte PoM
• 4.3.2 Islet β-cell PoM
• 4.4 Discussion
• References
• Chapter 5 Realizing Synaptic Signal Transmission During Astrocyte-Neuron Interactions within the EMI Framework
• 5.1 Introduction
• 5.2 Methods
• 5.2.1 Representation of the Computational Domain
• 5.2.2 Mathematical Modeling of Glutamate Dynamics
• 5.2.3 Modeling AMPA Gating Dynamics
• 5.2.4 Estimation of Model Parameters
• 5.2.5 Numerical Methods
• 5.3 Results
• 5.4 Discussion
• References
• Chapter 6 Inducing Flow Instabilities in Aneurysm Geometries via the Reynolds-Orr Method
• 6.1 Introduction
• 6.2 Methods
• 6.2.1 Reynolds-Orr Instability
• 6.2.2 Unsteady Navier-Stokes FEM Discretization
• 6.3 Results
• 6.4 Discussion
• References
• Chapter 7 Impact of Pathological Vascular Remodelling on Right Ventricular Mechanics
• 7.1 Introduction
• 7.2 Methods
• 7.2.1 Base Model of PAH
• 7.2.2 Ventricular Interaction and the Pericardium
• 7.2.3 Right Ventricular Remodelling and Baroreflex
• 7.2.4 Atrial Septostomy
• 7.2.5 Right Ventricular Assistive Device (RVAD)
• 7.3 Results
• 7.3.1 Sensitivity Analysis
• 7.3.2 Ventricular Interaction and the Pericardium
• 7.3.3 Remodelling the Right Ventricle
• 7.3.4 Atrial Septostomy
• 7.3.5 Right Ventricular Assistive Device
• 7.4 Discussion
• 7.5 Conclusion
• References.