Computational Physiology : : Simula Summer School 2022 Student Reports.

• Superior document: Simula SpringerBriefs on Computing Series ; v.13
• Author: McCabe, Kimberly J.
• Place / Publishing House: Cham : : Springer,, 2023.; ©2023.
• Year of Publication: 2023
• Edition: 1st ed.
• Language: English
• Series: Simula SpringerBriefs on Computing Series
• Physical Description: 1 online resource (118 pages)

Table of Contents

Intro -- Preface -- Acknowledgements -- Contents -- Chapter 1 An Automated Cardiac Constitutive Modelling Framework with Evolutionary Strain Energy Functions -- 1.1 Introduction -- 1.2 Methods -- 1.2.1 Basic Principles of Hyperelastic Continuum Mechanics -- 1.2.2 Representation of the Strain-Energy Functions as Function Trees -- 1.2.3 Fitting the Strain-Energy Functions to Experimental Data -- 1.2.3.1 Experimental Data under Consideration -- 1.2.3.2 Fitting to the Experimental Data -- 1.2.4 Evolutionary Symbolic Regression Algorithm -- 1.2.4.1 Setup and Initialisation -- 1.2.4.2 Mutation and Mating of Strain-Energy Functions -- 1.2.4.3 Scoring Fitness of Strain-Energy Functions -- 1.3 Results -- 1.3.1 Trial 1: SEF Describing the Shear Data -- 1.3.2 Trial 2: SEF Describing the Shear and Biaxial Data -- 1.4 Discussion -- 1.5 Conclusions -- References -- Chapter 2 Electromechanical In Silico Testing Alters Predicted Drug-Induced Risk to Develop Torsade de Pointes -- 2.1 Introduction -- 2.2 Methods -- 2.2.1 Drug Implementation -- 2.2.2 SimCardEMS Simulations -- 2.2.3 Evaluation -- 2.3 Results -- 2.3.1 Action Potential Duration -- 2.3.2 ElectromechanicalWindow -- 2.3.3 Maximum Active Tension -- 2.3.4 In Silico and in Vitro TdP Risk Classifications -- 2.4 Conclusions -- References -- Chapter 3 In silico Investigation of Sex-Specific Osteoarthritis in Human Articular Chondrocytes -- 3.1 Introduction -- 3.2 Methods -- 3.2.1 Modeling Ionic Changes Induced by Osteoarthritis in Male and Female Chondrocytes -- 3.2.2 Generation of a Population of Models -- 3.2.3 Model Parameter Sensitivity Analysis -- 3.3 Results -- 3.3.1 Modeling the Impact of Sex-Specific OA on Resting Membrane Potential -- 3.3.2 Population of Models -- 3.3.3 Parameter Sensitivity Analysis -- 3.3.4 Inhibiting INaK Restores Normal Resting Membrane Potential in OA Chondrocytes.

3.4 Discussion -- 3.5 Conclusions -- References -- Chapter 4 Recapitulating Functional Heterogeneity in Electrophysiologically Active Tissues -- 4.1 Introduction -- 4.2 Methods -- 4.2.1 Cardiomyocytes -- 4.2.2 Islet β-cells -- 4.3 Results -- 4.3.1 Cardiomyocyte PoM -- 4.3.2 Islet β-cell PoM -- 4.4 Discussion -- References -- Chapter 5 Realizing Synaptic Signal Transmission During Astrocyte-Neuron Interactions within the EMI Framework -- 5.1 Introduction -- 5.2 Methods -- 5.2.1 Representation of the Computational Domain -- 5.2.2 Mathematical Modeling of Glutamate Dynamics -- 5.2.3 Modeling AMPA Gating Dynamics -- 5.2.4 Estimation of Model Parameters -- 5.2.5 Numerical Methods -- 5.3 Results -- 5.4 Discussion -- References -- Chapter 6 Inducing Flow Instabilities in Aneurysm Geometries via the Reynolds-Orr Method -- 6.1 Introduction -- 6.2 Methods -- 6.2.1 Reynolds-Orr Instability -- 6.2.2 Unsteady Navier-Stokes FEM Discretization -- 6.3 Results -- 6.4 Discussion -- References -- Chapter 7 Impact of Pathological Vascular Remodelling on Right Ventricular Mechanics -- 7.1 Introduction -- 7.2 Methods -- 7.2.1 Base Model of PAH -- 7.2.2 Ventricular Interaction and the Pericardium -- 7.2.3 Right Ventricular Remodelling and Baroreflex -- 7.2.4 Atrial Septostomy -- 7.2.5 Right Ventricular Assistive Device (RVAD) -- 7.3 Results -- 7.3.1 Sensitivity Analysis -- 7.3.2 Ventricular Interaction and the Pericardium -- 7.3.3 Remodelling the Right Ventricle -- 7.3.4 Atrial Septostomy -- 7.3.5 Right Ventricular Assistive Device -- 7.4 Discussion -- 7.5 Conclusion -- References.