Inflammation in Cancellous and Cortical Bone Healing.

• Superior document: Linköping University Medical Dissertations Series ; v.1668
• Author: Tätting, Love.
• Place / Publishing House: Linköping : : Linkopings Universitet,, 2019.; {copy}2019.
• Year of Publication: 2019
• Edition: 1st ed.
• Language: English
• Series: Linköping University Medical Dissertations Series
• Physical Description: 1 online resource (80 pages)

Table of Contents

Intro -- POPULÄRVETENSKAPLIG SAMMANFATTNING -- ABSTRACT -- Acknowledgments -- Contents -- List of Figures -- List of Tables -- List of Terms -- List of Cell Types -- List of Phenotypic Markers -- Thesis at a Glance -- List of Papers -- Relevant Work Not Included in This Thesis -- Nomenclature -- Anatomy vs. Physiology -- Introduction -- Previous Work -- Background and Rationale -- Research Aims -- Inflammation in Bone Healing -- Blood Counts Differ Between Humans and Mice -- Myeloid Cells -- Granulocytes Might Be Important Initiators of Fracture Healing -- Monocytes Show a Continuum of Functionality -- M1 and M2 Macrophages in Bone Healing -- Macrophages Appear Vital To Osteoblasts -- Lymphoid Cells -- Lymphocytes Are Indeed Present at the Fracture Site -- Subsets of Lymphocytes Might Have Specific Roles in Bone Healing -- The Role of B Cells in Fracture Healing Is Unknown -- Anti-inflammatory Agents -- Nerves Supply Trophic Signals To Bone -- Comments on Material and Methods -- Models of Fracture Healing -- Do Mice Faithfully Model Human Bone Healing? -- Fracture Models in Mice Are Synonymous with Shaft Fracture -- Cancellous Model -- Cortical Model -- Bone Healing Model vs. Fracture Model -- Flow Cytometry -- Finding Cells in Bone -- Finding Cells in the Flow Cytometer -- Where Does a Cloud Really End? -- Some Phenotypes Are Bright and Some Dull -- Mass Spectrometry -- The power of a p value -- Results and Discussion -- Inflammatory Response on Metaphsyeal Trauma -- Mirrored Inflammation -- The Systemic Response Is Not Neurally Mediated -- Cells Specific To Cancellous Bone Healing -- M1 and M2 -- Lymphocytes -- Macrophages Are Essential -- Different Cell Recruitment -- Different Response -- Inflammations is Increased at Day 3 -- The Role of B Cells in Fracture Healing Is Unknown -- Concluding Remarks and Future -- Bibliography -- Papers.