Micro-, Meso- and Macro-Connectomics of the Brain.

• Superior document: Research and Perspectives in Neurosciences Series
• Author: Kennedy, Henry.
• TeilnehmendeR: Van Essen, David C.; Christen, Yves.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2016.; Ã2016.
• Year of Publication: 2016
• Edition: 1st ed.
• Language: English
• Series: Research and Perspectives in Neurosciences Series
• Physical Description: 1 online resource (173 pages)

Table of Contents

Intro -- Acknowledgments -- Contents -- List of Contributors -- Nanoconnectomics -- Nanoconnectomics -- Extracellular Space -- Simulating Signaling in Small Spaces -- Precision of Synaptic Plasticity -- References -- Inhibitory Cell Types, Circuits and Receptive Fields in Mouse Visual Cortex -- Differences in Connectivity, Visual Responses and Functional Impact of PV Versus SST Interneurons -- Calretinin (CR) and VIP-Expressing Interneurons Target SST Interneurons -- Functional Impact of VIP Interneurons -- References -- Form Meets Function in the Brain: Observing the Activity and Structure of Specific Neural Connections -- Introduction -- CLARITY -- Clarifying Large Tissue Volumes -- CLARITY-Optimized Light Sheet Microscopy -- Tracking Activity in Deep Genetically Targeted Neurons of Behaving Animals -- Neural Activity that Encodes and Predicts Social Interaction -- Outlook -- References -- The Network for Intracortical Communication in Mouse Visual Cortex -- Introduction -- Thalamocortical Projections to Mouse Visual Cortex -- Cortical Cartography -- Areal Organization of Visual Cortex -- Interareal Connections -- Cortical Hierarchy -- Synaptic Organization of Feedforward and Feedback Connections -- Dorsal and Ventral Processing Streams -- References -- The Brain in Space -- Introduction -- The Promise of Network Theory -- Empirical Evidence for a Principled Model of Cortical Connectivity: The EDR Model -- The Cortical Core-Periphery Structure -- Biology, Clustering and the Importance of Weak Links -- Conclusion and Perspectives -- References -- In-Vivo Connectivity in Monkeys -- Anatomical, Functional and Effective Connectivity in Animal Models -- Towards Causality: Effective Connectivity with Focal Perturbation Tools -- Effective Connectivity: Combined Electrical Microstimulation and Whole-Brain fMRI.

Novel Genetically-Based Perturbation Methods? -- References -- Parcellations and Connectivity Patterns in Human and Macaque Cerebral Cortex -- Introduction -- Cortical Cartography and Parcellation -- Distributed Cortical Connectivity -- Interspecies Registration -- Concluding Comments -- References -- Connectome Networks: From Cells to Systems -- Defining the Connectome -- Brain Networks and Graph Theory -- Topology of Structural Brain Networks -- Microscale -- Mesoscale -- Macroscale -- Comparison Across Scales and Challenges -- Relations Between Structure and Function -- Microscale -- Mesoscale -- Macroscale -- Comparison Across Scales and Challenges -- Future Perspectives -- References -- Intra- and Inter-hemispheric Connectivity Supporting Hemispheric Specialization -- Introduction -- Human Dualism: Two Hands, Two Brains -- Asymmetries Measured with Brain Imaging -- Anatomo-Functional Support of HS -- Gray Matter Macroscopic Asymmetries and HS -- White Matter Connections Supporting HS -- Corpus Callosum -- Intra-hemispheric Structural Connectivity -- Functional Asymmetries and Hemispheric Dominance for Language Assessed with Meta-analysis -- Developmental Course of the Setting Up of Anatomical and Functional Asymmetries -- HS, Cognitive Abilities and Developmental/Psychiatric Diseases -- Cognitive Skills and Asymmetries -- Language HS, Developmental and Psychiatric Diseases -- Inter-individual Variability in HS: Factors at Play -- BILandGIN: A Multimodal Database for Investigating HS -- Conclusion -- References -- Genetics of the Connectome and the ENIGMA Project -- Background to ENIGMA -- Genetic Influences on the Brain -- Finding the Genes Involved -- GWAS of the Brain -- Counterarguments and Power -- Non-biological Information Arising from ENIGMA -- But Do the ENIGMA Genes Affect Disease Risk? -- Searching Brain Images for Statistical Effects.

Brain-Wide Genome-Wide Scanning -- Genetic Screening of the Connectome -- Caveats for Multi-site Genomic Analysis of the Connectome -- Future Directions: Adaptive Connectomics and EPIC -- References -- Index.