A Time for Metabolism and Hormones.

• Superior document: Research and Perspectives in Endocrine Interactions Series
• Author: Sassone-Corsi, Paolo.
• TeilnehmendeR: Christen, Yves.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2016.; ©2016.
• Year of Publication: 2016
• Edition: 1st ed.
• Language: English
• Series: Research and Perspectives in Endocrine Interactions Series
• Physical Description: 1 online resource (141 pages)

Table of Contents

• Intro
• Preface
• Acknowledgements
• Contents
• List of Contributors
• The Epigenetic and Metabolic Language of the Circadian Clock
• Introduction
• Chromatin Remodeling, Cyclic Transcription and the Clock
• Cellular Metabolism and the Circadian Clock Converge
• The Central Role of Sirtuins
• Conclusion
• References
• Molecular Architecture of the Circadian Clock in Mammals
• Introduction
• Structural Biology of Clock Proteins
• Transcriptional Architecture and Chromatin Dynamics of the Clock
• References
• Circadian Mechanisms in Bioenergetics and Cell Metabolism
• Genetic Approaches to Dissecting Circadian Physiology
• Clock-NAD+-Sirtuin Pathway in Bioenergetics
• Reciprocal Control of the Clock by Nutrient
• Summary and Future Directions
• References
• Control of Metabolism by Central and Peripheral Clocks in Drosophila
• Use of Drosophila to Study Behavior and Metabolic Function
• The Drosophila Fat Body Contains a Clock that Regulates a Rhythm of Feeding
• Fat Body and Neuronal Clocks Coordinately Regulate Metabolic Parameters
• Rhythmic Gene Expression in the Fat Body Is Controlled Largely, but not Exclusively, by the Fat Body Clock
• A Restricted Feeding Paradigm Resets the Phase of Cyclic Gene Expression in the Fat Body but not in the Brain
• Decoupling Peripheral and Brain Tissues Decreases Reproductive Fitness
• Metabolic Signals Also Affect Clocks in the Brain
• References
• Circadian Post-transcriptional Control of Metabolism
• Introduction
• Post-transcriptional Mechanisms
• Circadian Control of poly(A) Tail Length
• Nocturnin Is a Circadian Deadenylase
• Loss of Nocturnin Results in Broad Metabolic Changes
• Conclusions
• References
• Redox and Metabolic Oscillations in the Clockwork
• Introduction
• Challenging Transcriptional Models of the Clockwork
• Non-transcriptional Clock Mechanisms.
• PRDX Rhythms
• Redox and Metabolic Clocks in Eukaryotes
• Conclusion
• References
• Rev-erbs: Integrating Metabolism Around the Clock
• Introduction
• Repression of Transcription by Rev-erbs
• Circadian Biology of Rev-erbs
• Rev-erbα and Metabolism
• Conclusions
• References
• Control of Sleep-Wake Cycles in Drosophila
• Background
• Layout of the Network in Constant Conditions
• Network Architecture Under LD Cycles
• References
• Circadian Metabolomics: Insights for Biology and Medicine
• Introduction: A Many-Clock Problem
• An Overview of Circadian Metabolomics
• Metabolomics: Applications for Circadian Medicine
• Outlook and Conclusion
• References
• Rhythms Within Rhythms: The Importance of Oscillations for Glucocorticoid Hormones
• Introduction
• The Origin of HPA Pulsatility
• Implications of HPA Pulsatility
• Adrenal Adaptation to Pulsatile ACTH
• Tissue Adaptation to Pulsatile CORT
• Conclusion
• References
• The Genetics of Autism Spectrum Disorders
• Introduction
• Twin and Family Studies in ASD
• From Chromosomal Rearrangements to Copy Number Variants in ASD
• From Candidate Genes to Whole Exome/Genome Sequencing Studies in ASD
• The Common Variants in ASD
• The Genetic Architecture of ASD
• The Biological Pathways Associated with ASD
• The Serotonin-NAS-Melatonin Pathway
• Perspectives
• References
• Index.