A Time for Metabolism and Hormones.

• Superior document: Research and Perspectives in Endocrine Interactions Series
• Author: Sassone-Corsi, Paolo.
• TeilnehmendeR: Christen, Yves.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2016.; ©2016.
• Year of Publication: 2016
• Edition: 1st ed.
• Language: English
• Series: Research and Perspectives in Endocrine Interactions Series
• Physical Description: 1 online resource (141 pages)

Table of Contents

Intro -- Preface -- Acknowledgements -- Contents -- List of Contributors -- The Epigenetic and Metabolic Language of the Circadian Clock -- Introduction -- Chromatin Remodeling, Cyclic Transcription and the Clock -- Cellular Metabolism and the Circadian Clock Converge -- The Central Role of Sirtuins -- Conclusion -- References -- Molecular Architecture of the Circadian Clock in Mammals -- Introduction -- Structural Biology of Clock Proteins -- Transcriptional Architecture and Chromatin Dynamics of the Clock -- References -- Circadian Mechanisms in Bioenergetics and Cell Metabolism -- Genetic Approaches to Dissecting Circadian Physiology -- Clock-NAD+-Sirtuin Pathway in Bioenergetics -- Reciprocal Control of the Clock by Nutrient -- Summary and Future Directions -- References -- Control of Metabolism by Central and Peripheral Clocks in Drosophila -- Use of Drosophila to Study Behavior and Metabolic Function -- The Drosophila Fat Body Contains a Clock that Regulates a Rhythm of Feeding -- Fat Body and Neuronal Clocks Coordinately Regulate Metabolic Parameters -- Rhythmic Gene Expression in the Fat Body Is Controlled Largely, but not Exclusively, by the Fat Body Clock -- A Restricted Feeding Paradigm Resets the Phase of Cyclic Gene Expression in the Fat Body but not in the Brain -- Decoupling Peripheral and Brain Tissues Decreases Reproductive Fitness -- Metabolic Signals Also Affect Clocks in the Brain -- References -- Circadian Post-transcriptional Control of Metabolism -- Introduction -- Post-transcriptional Mechanisms -- Circadian Control of poly(A) Tail Length -- Nocturnin Is a Circadian Deadenylase -- Loss of Nocturnin Results in Broad Metabolic Changes -- Conclusions -- References -- Redox and Metabolic Oscillations in the Clockwork -- Introduction -- Challenging Transcriptional Models of the Clockwork -- Non-transcriptional Clock Mechanisms.

PRDX Rhythms -- Redox and Metabolic Clocks in Eukaryotes -- Conclusion -- References -- Rev-erbs: Integrating Metabolism Around the Clock -- Introduction -- Repression of Transcription by Rev-erbs -- Circadian Biology of Rev-erbs -- Rev-erbα and Metabolism -- Conclusions -- References -- Control of Sleep-Wake Cycles in Drosophila -- Background -- Layout of the Network in Constant Conditions -- Network Architecture Under LD Cycles -- References -- Circadian Metabolomics: Insights for Biology and Medicine -- Introduction: A Many-Clock Problem -- An Overview of Circadian Metabolomics -- Metabolomics: Applications for Circadian Medicine -- Outlook and Conclusion -- References -- Rhythms Within Rhythms: The Importance of Oscillations for Glucocorticoid Hormones -- Introduction -- The Origin of HPA Pulsatility -- Implications of HPA Pulsatility -- Adrenal Adaptation to Pulsatile ACTH -- Tissue Adaptation to Pulsatile CORT -- Conclusion -- References -- The Genetics of Autism Spectrum Disorders -- Introduction -- Twin and Family Studies in ASD -- From Chromosomal Rearrangements to Copy Number Variants in ASD -- From Candidate Genes to Whole Exome/Genome Sequencing Studies in ASD -- The Common Variants in ASD -- The Genetic Architecture of ASD -- The Biological Pathways Associated with ASD -- The Serotonin-NAS-Melatonin Pathway -- Perspectives -- References -- Index.