Stem Cells in Neuroendocrinology.

• Superior document: Research and Perspectives in Endocrine Interactions Series
• Author: Pfaff, Donald.
• TeilnehmendeR: Christen, Yves.
• Place / Publishing House: Cham : : Springer International Publishing AG,, 2016.; ©2016.
• Year of Publication: 2016
• Edition: 1st ed.
• Language: English
• Series: Research and Perspectives in Endocrine Interactions Series
• Physical Description: 1 online resource (163 pages)

Table of Contents

Intro -- Introduction -- Acknowledgments -- Contents -- List of Contributors -- A Brief Overview of Techniques for Modulating Neuroendocrine and Other Neural Systems -- A Brief View of the Oldest, Most Primitive Approaches -- The Disciplines -- Morphology -- Physiology -- Chemistry -- Genetics, Genomics -- Cognitive Neuroscience -- Computational Approaches -- A Brief Survey of Emerging Techniques for Neuromodulation -- Electrical -- Chemical -- Genetic -- Viral -- Computational -- Special Opportunities for Manipulating the Unique Products of Neuroendocrine Neurons -- This Volume -- Further Reading -- Basics of Stem Cell Biology as Applied to the Brain -- Introduction -- The Basic Biology of Stem Cells -- Preimplantation Development and Embryonic Stem (ES) Cells -- Derivation and Maintenance of Pluripotent Stem Cells: Differences Between Mouse and Human -- How to Test Pluripotency? -- Opportunities and Challenges for Using ES Cells in Medicine -- Obtaining Cells Genetically Matched to Patients: Reprogramming, Cloning, and Induced Pluripotent Stem Cells -- Opportunities and Challenges of Producing Hypothalamic Neurons from Stem Cells -- Direct Reprogramming: An Alternative Pathway to Obtaining Patient-Matched Neuron-Like Cells -- Relevance of In Vitro Cell Types to Neuronal Biology -- Outlook -- References -- Human Pluripotent-Derived Lineages for Repairing Hypopituitarism -- Derivation of Human Neural Cell Types for Regenerative Medicine -- Derivation and Application of Human Pituitary Lineages -- Perspectives and Challenges on the Road to Translation -- Conclusion -- References -- Recapitulating Hypothalamus and Pituitary Development Using Embryonic Stem/Induced Pluripotent Stem Cells -- Introduction -- A Need for Hypothalamus and Adenohypophysis Regenerative Medicine -- Mouse ES Cells -- Pituitary Gland Embryology.

Three-Dimensional ES Cell Culture -- Induction of Hypothalamic Neurons from Mouse ES Cells -- Two-Layer Formation In Vitro Is the First Step of Adenohypohysis Differentiation -- Self-Formation of Rathkeś Pouch -- Differentiation Into Hormone-Producing Endocrine Cells -- Functionality of Induced ACTH+ Cells -- Effect of Transplantation Into Hypophysectomized Model Animals -- Adaptation to Human ES/iPS Cell Culture -- Future Perspectives -- References -- Regulation of Body Weight and Metabolism by Tanycyte-Derived Neurogenesis in Young Adult Mice -- Introduction -- Material and Methods -- Animals -- Caloric Restriction -- Reagents -- Bromodeoxyuridine (BrdU) -- Tissue Processing and Antibodies -- Immunohistochemistry -- Cell Quantification -- Focal Irradiation of Ventrobasal Hypothalamus -- Longitudinal Collection of Weight Data -- Statistical Analysis -- Results -- Dietary Signals Differentially Regulate Neurogenesis and Cell Proliferation in ME and ArcN -- Sex-Specific Differences in Diet-Induced Hypothalamic Neurogenesis -- Blocking Neurogenesis in ME Attenuates HFD-Induced Weight Gain in Young Adult Female, But Not Male, Mice -- Discussion -- References -- Genetic Dissection of the Neuroendocrine and Behavioral Responses to Stressful Challenges -- References -- Pituitary Stem Cells: Quest for Hidden Functions -- Introduction -- Primer on Pituitary Biology and Pathology -- Pituitary Stem Cells: Expanding Molecular Portrayal -- Pituitary Stem Cells: Uncovering the Hidden Functions -- Neonatal Pituitary Maturation -- Basal and Adapting Adult Pituitary -- Pituitary Regeneration and Impact of Aging -- Pituitary Tumorigenesis -- Conclusion and General Perspectives -- References -- Pituitary Stem Cells During Normal Physiology and Disease -- Introduction -- The Long-Term Maintenance of the Anterior Pituitary -- Stem Cells and Pituitary Tumours.

References -- Epigenetic Mechanisms of Pituitary Cell Fate Specification -- Introduction -- Escaping Stemness -- Intermediate Pituitary Identity -- Pax7 Opens a New Enhancer Repertoire -- The Essence of Pioneering -- Succeeding at Multiple Choices or Avoiding Cellular Schizophrenia -- Future Challenges -- References -- Advances in Stem Cells Biology: New Approaches to Understand Depression -- Introduction -- How Can We Best Study Depression? -- The Neurogenesis Theory of Depression -- Experimental Approaches -- Immortalized Human Neural Cell Lines -- Neural Stem Cell Lines -- Modeling the Role of Stress -- Modeling the Role of Inflammation and Oxidative Stress -- Studying Mechanism of Action of Antidepressants -- Tumour-Derived Cell Lines -- Patient-Derived Neural Cells -- IPSCs -- Olfactory Neuroepithelium-Derived Stem Cells -- Conclusions and Limitations of the Cell Models -- References -- Perspective on Stem Cells in Developmental Biology, with Special Reference to Neuroendocrine Systems -- Introduction -- Morphogenesis of the Hypothalamo-Pituitary Axis (Fig.1) -- Hypothalamus -- Pituitary -- Characterization of AdSC in the Hypothalamo-Pituitary Axis (Fig.3) -- Hypothalamus -- Pituitary -- In vitro Recapitulation of Ontogenesis in the Hypothalamo-Pituitary Axis (Fig.3) -- Induction of Hypothalamic Identity from 3D ESC Aggregates -- Generation of Hypothalamic Neurons from 2D ESC Cultures -- Induction of RP from 3D Aggregates -- Perspectives -- Differentiation Strategies -- Implantation in Homotypic Locations -- Conclusion -- References.