On Protein Structure, Function and Modularity from an Evolutionary Perspective.

• Superior document: Linköping Studies in Science and Technology. Dissertations Series ; v.1914
• Author: Pilstål, Robert.
• Place / Publishing House: Linköping : : Linkopings Universitet,, 2018.; {copy}2018.
• Year of Publication: 2018
• Edition: 1st ed.
• Language: English
• Series: Linköping Studies in Science and Technology. Dissertations Series
• Physical Description: 1 online resource (204 pages)

Table of Contents

Intro -- Abstract -- Acknowledgments -- Author Contributions -- Contents -- List of Figures -- Abbreviations -- Introduction -- What is Science? -- Life and its Molecules -- Proteins - order and disorder -- Systems -- Thesis -- Method -- Alignments -- Contact prediction -- Structure prediction -- Dynamics simulation -- Clustering analysis -- Essential Dynamics Analysis -- Graphs and Structures -- Allosteric Network Analysis -- Ensemble Quality Assessment -- Present Investigations -- Function in transiently ordered islets of intrinsically disordered proteins (Paper I) -- Functional analysis of protein structure dynamics using graph models and multivariate statistics (Paper II) -- Improvements in Protein Model Quality Assessment from Automated Domain Partitioning using Spectral Clustering (Paper III and Manuscript I) -- Functional Interaction Network of c-MYC Conserved Regions determined by Evolutionary Couplings (Manuscript II) -- Conclusion -- Future Perspectives -- Bibliography -- Paper I -- Paper II -- Paper III -- Manuscript I -- Manuscript II.