Evaluation of the Dual-Modal Usage of Contrast Agents by Means of Synchrotron X-Ray Computed Microtomography and Magnetic Resonance Imaging Using Macrophages Loaded with Barium Sulfate and Gadolinium Nanoparticles for Detection and Monitoring in Animal Di.

• Superior document: Linköping Studies in Science and Technology. Dissertations Series ; v.1707
• Author: Larsson, Emanuel.
• Place / Publishing House: Linköping : : Linkopings Universitet,, 2015.; {copy}2015.
• Year of Publication: 2015
• Edition: 1st ed.
• Language: English
• Series: Linköping Studies in Science and Technology. Dissertations Series
• Physical Description: 1 online resource (99 pages)

Table of Contents

• Intro
• Dedication
• Abstract
• Populärvetenskaplig sammanfattning
• Sommario
• List of publications
• Author's Contribution
• Related publications
• Contents
• List of Figures
• Acronyms
• 1 Introduction
• 1.1 Objective
• 1.2 Thesis outline
• 2 Contrast Agents
• 2.1 Contrast agents for Computed Tomography
• 2.2 Contrast agents for Magnetic Resonance Imaging
• 2.3 Selection and development of a multi-modal contrast agent for MRI and CT
• 3 Animal Disease Models
• 3.1 Experimental design
• 3.1.1 Pilot studies &amp
• sample sizes
• 3.2 Selection of an animal disease model expressing inflammations
• 3.2.1 Animal model used in this thesis - an asthmatic mouse model
• 4 Tomographic Imaging Modalities
• 4.1 Computed Tomography
• 4.1.1 Production of Conventional X-rays
• 4.1.2 Experimental setup of CT vs -CT
• 4.1.3 Synchrotron Radiation-CT
• 4.1.4 Synchrotron Radiation-CT vs conventional -CT
• 4.1.5 X-rays interaction with matter and the attenuation of X-rays
• 4.1.6 Image quality
• 4.2 Magnetic Resonance Imaging
• 4.2.1 NMR Background
• 4.2.2 Net magnetization
• 4.2.3 Relaxation
• 4.2.4 Image contrast
• 4.2.5 Encoding the MR-signal
• 4.2.6 Imaging parameters
• 5 Image Post Processing
• 5.1 Image Quality
• 5.2 Segmentation Techniques
• 5.3 Volume Rendering
• 5.4 Selection of Volume of Interest
• 5.5 Quantitative &amp
• Statistical Image Analysis
• 5.6 Image Registration
• 6 Summary of papers
• 6.1 Paper I:
• 6.2 Paper II:
• 6.3 Paper III:
• 6.4 Paper IV:
• 6.5 Paper V:
• 7 Final discussion
• 8 Future Outlook
• Acknowledgments
• Bibliography.