Evaluation of the Dual-Modal Usage of Contrast Agents by Means of Synchrotron X-Ray Computed Microtomography and Magnetic Resonance Imaging Using Macrophages Loaded with Barium Sulfate and Gadolinium Nanoparticles for Detection and Monitoring in Animal Di.

• Superior document: Linköping Studies in Science and Technology. Dissertations Series ; v.1707
• Author: Larsson, Emanuel.
• Place / Publishing House: Linköping : : Linkopings Universitet,, 2015.; {copy}2015.
• Year of Publication: 2015
• Edition: 1st ed.
• Language: English
• Series: Linköping Studies in Science and Technology. Dissertations Series
• Physical Description: 1 online resource (99 pages)

Table of Contents

Intro -- Dedication -- Abstract -- Populärvetenskaplig sammanfattning -- Sommario -- List of publications -- Author's Contribution -- Related publications -- Contents -- List of Figures -- Acronyms -- 1 Introduction -- 1.1 Objective -- 1.2 Thesis outline -- 2 Contrast Agents -- 2.1 Contrast agents for Computed Tomography -- 2.2 Contrast agents for Magnetic Resonance Imaging -- 2.3 Selection and development of a multi-modal contrast agent for MRI and CT -- 3 Animal Disease Models -- 3.1 Experimental design -- 3.1.1 Pilot studies &amp -- sample sizes -- 3.2 Selection of an animal disease model expressing inflammations -- 3.2.1 Animal model used in this thesis - an asthmatic mouse model -- 4 Tomographic Imaging Modalities -- 4.1 Computed Tomography -- 4.1.1 Production of Conventional X-rays -- 4.1.2 Experimental setup of CT vs -CT -- 4.1.3 Synchrotron Radiation-CT -- 4.1.4 Synchrotron Radiation-CT vs conventional -CT -- 4.1.5 X-rays interaction with matter and the attenuation of X-rays -- 4.1.6 Image quality -- 4.2 Magnetic Resonance Imaging -- 4.2.1 NMR Background -- 4.2.2 Net magnetization -- 4.2.3 Relaxation -- 4.2.4 Image contrast -- 4.2.5 Encoding the MR-signal -- 4.2.6 Imaging parameters -- 5 Image Post Processing -- 5.1 Image Quality -- 5.2 Segmentation Techniques -- 5.3 Volume Rendering -- 5.4 Selection of Volume of Interest -- 5.5 Quantitative &amp -- Statistical Image Analysis -- 5.6 Image Registration -- 6 Summary of papers -- 6.1 Paper I: -- 6.2 Paper II: -- 6.3 Paper III: -- 6.4 Paper IV: -- 6.5 Paper V: -- 7 Final discussion -- 8 Future Outlook -- Acknowledgments -- Bibliography.