Integrated cardiac safety : assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance / / J. Rick Turner, Todd A. Durham.

• Author: ProQuest (Firm); Turner, J. Rick.
• TeilnehmendeR: Durham, Todd A.; ProQuest (Firm)
• Year of Publication: 2009
• Language: English
• Physical Description: xxviii, 470 p. :; ill.

Table of Contents

• The importance of cardiac safety assessments
• The biological basis of adverse drug reactions
• Cardiac structure and function
• Cardiac pathophysiology and disease
• Drug discovery and drug design
• Nonclinical development
• The thorough QT/QTc trial
• General safety assessments
• Therapeutic use trials and meta-analyses
• Assessment methodologies in nonexperimental postmarketing surveillance
• Postmarketing proarrhythmic cardiac safety assessments
• Generalized cardiac safety
• Medication errors, adherence, and concordance
• Future directions in drug safety.