Using animal models in biomedical research : a primer for the investigator / / Pierce K.H. Chow, Robert T.H. Ng, Bryan E. Ogden.

• Author: ProQuest (Firm); Chow, Pierce K. H.
• TeilnehmendeR: Ng, Robert T. H.; Ogden, Bryan E.; ProQuest (Firm)
• Year of Publication: 2008
• Language: English
• Physical Description: xviii, 290 p. :; ill. (some col.).

Table of Contents

1. Scientific considerations and choice of species. The rationale for the use of animal models in biomedical research / Pierce Chow. Experimental animal models in biomedical resarch / Robert Ng. Nonhuman primates as models in biomedical research / Jason Vilano and Bryan Ogden -- 2. Regulatory considerations in the use of animal models. Laws, regulations and guidelines for biomedical research in Singapore / Boon Theng Kuah. The functions of the institutional animal care and use committee / Pierce Chow. Responsibilities of principal investigators and research protocol evaluation / Hock Soo Ong. The 3r's, research variables and the use of alternatives / Hock Soo Ong. Use of statistics as determinant for number of animals used / Huihua Li. The advantages of accreditation with AAALAC / Bryan Ogden -- 3. Animal handling and surgical procedures. General handling, restraint, oral dosing/gavage and injections in laboratory animals / Bryan Ogden. Blood collection from laboratory animals / Jason Villano. Antibiotic coverage and therapy / Darvi Sergio. Animal preparation and transport / Robert Ng. Preparation and implementation of animal surgery / Robert Ng. Animal intubation / Robert Ng. Anaesthesia and maintenance of homeostasis / Robert Ng. animal euthanasia / Darvi Sergio. Rodent sentinel programme / Peik Khin Tan --

4. Basic animal investigative methods. Bioimaging in animals / David Ng ... [et al.]. Histology sampling and techniques / In Chin Song. Animal tissue perfusion and preservation / Robert Ng. Animal cell culture / Peggy Yong and Kai Zhang. Application of microsurgical techniques in animal research / Bien Keem Tan ... [et al.] -- 5. Animal welfare considerations. Species specific caging configuration and design / Cindy Phua. Postoperative care and pain management / Jason Villano. animal feeds and nutritional requirements / Peik Khin Tan -- 6. Safety management of an animal facility. Occupational health and safety programme / Angela Goh. New employee and external users orientation / Inria Kurniawan Then. Radiation safety awareness in animal research / S. Somanesan. Emergency crisis management / Irene Kee. Zoonoses and laboratory animal allergies / Jason Villano -- 7. Supporting facilities design. clinical skills laboratory / Robert Ng. Animal research supporting laboratories / Robert Ng. animal research and housing facilities / Robert Ng -- 8. The development of comprehensive animal facilities in Singapore. History of the Department of Experimental Surgery as a reflection of translational research development in Singapore / Robert Ng -- Append. 1. Accredited laboratories for import of experimental animals -- Append. 2. Radiation safety data -- Append. 3. Anaesthesia for laboratory animals -- Append. 4. Analgesics and therapeutics for laboratory animals -- Append. 5. Passively transmitted zoonotic organisms.