Nanofibres in drug delivery / / Gareth R. Williams [and three others].

• VerfasserIn: Williams, Gareth R.,; Luo, C. J.,; Raimi-Abraham, Bahijja T.,
• TeilnehmendeR: Luo, C. J.,; Raimi-Abraham, Bahijja T.,
• Place / Publishing House: London : : University College London,, 2018.
• Year of Publication: 2018
• Language: English
• Physical Description: 1 online resource (242 pages) :; illustrations (some color)

In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory. The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibre can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.

Table of Contents

Intro; Half Title; Title Page; Copyright Page; Acknowledgements; Contents; List of figures; List of abbreviations; 1 Introduction; 1.1 Preamble; 1.2 Nanofibres; 1.3 Key concepts in drug delivery; 1.3.1 The therapeutic window and bioavailability; 1.3.2 Modified-release systems; 1.3.3 Dissolution, solubility and permeability; 1.3.4 Physical form; 1.4 Nanofibre characterisation; 1.4.1 Electron microscopy; 1.4.2 X-ray diffraction; 1.4.3 Thermal methods; 1.4.4 Infrared spectroscopy; 1.4.5 Functional performance; 1.4.5.1 Dissolution and permeability testing; 1.4.5.2 API quantification 1.4.6 Stability studies1.5 An overview of contemporary pharmaceutical technology; 1.5.1 Hot melt extrusion; 1.5.2 Spray drying; 1.5.3 Freeze drying; 1.5.4 Nanofibre manufacturing; 1.6 Summary; References; 2 Electrospinning fundamentals; 2.1 Background; 2.2 A brief history of electrospinning; 2.3 EHD fundamentals; 2.4 Understanding the electrospinning process; 2.4.1 Jet initiation; 2.4.2 Electrospinning vs. electrospraying; 2.4.3 Jet elongation: bending and whipping; 2.4.4 Jet solidification; 2.5 The parameters affecting electrospinning; 2.5.1 Solution parameters; 2.5.2 Processing parameters 2.5.3 Environmental parameters2.5.4 Solvent and polymer selection; 2.6 The experimental set-up; 2.6.1 Basics; 2.6.2 The power supply and syringe pump; 2.6.3 The spinneret; 2.6.4 The collector; 2.6.5 Other considerations; 2.6.6 Establishing and troubleshooting an electrospinning process; 2.7 Fibre properties; 2.8 Characterisation; 2.9 Summary; References; 3 Monoaxial electrospinning; 3.1 Introduction; 3.2 Experimental considerations; 3.2.1 Solution parameters; 3.2.2 Processing parameters; 3.2.3 The spinneret; 3.2.4 Polymer choice; 3.2.5 Starting experimental work; 3.3 Fibre properties 3.4 Some typical results3.5 Fast-dissolving drug delivery systems; 3.5.1 Electrospun fast-dissolving drug delivery systems; 3.5.2 Caveats; 3.5.3 Multicomponent formulations; 3.5.4 Stability; 3.6 Extended-release systems; 3.6.1 Applications; 3.6.2 Drawbacks and release mechanisms; 3.7 pH-controlled delivery; 3.7.1 Oral administration; 3.7.2 Anticancer applications; 3.8 Pulsatile release; 3.9 Multilayer materials; 3.10 Thermoresponsive systems; 3.11 Emulsion and suspension electrospinning; 3.11.1 Emulsions; 3.11.2 Suspensions; 3.12 Tissue-engineering applications 3.13 Using fibres as sacrificial templates3.14 Conclusions; References; 4 Coaxial and multi-axial electrospinning; 4.1 Introduction; 4.2 Experimental considerations; 4.2.1 Handling two liquids; 4.2.2 The spinneret and electrodes; 4.2.3 Establishing a coaxial process; 4.3 Extended-release systems; 4.3.1 Preventing burst release; 4.3.2 Biphasic release; 4.4 Targeted drug delivery; 4.5 Multifunctional materials; 4.6 Other applications; 4.7 Protein delivery systems; 4.8 Cell electrospinning; 4.9 Modified coaxial spinning; 4.10 Triaxial and quad-axial systems; 4.11 Conclusions; References.