Nanoparticles in Ocular Drug Delivery Systems / / edited by Hugo Almeida and Ana Catarina Silva.
Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic effi...
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| Place / Publishing House: | [Place of publication not identified] : : MDPI - Multidisciplinary Digital Publishing Institute,, 2023. |
| Year of Publication: | 2023 |
| Language: | English |
| Physical Description: | 1 online resource (266 pages) |
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| Summary: | Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity. |
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| Hierarchical level: | Monograph |
| Statement of Responsibility: | edited by Hugo Almeida and Ana Catarina Silva. |