Transcriptional Regulation and Its Misregulation in Human Diseases / / Amelia Casamassimi, Alfredo Ciccodicola, Monica Rienzo.
Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extracellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity. This control involves...
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Place / Publishing House: | Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, 2023. |
Year of Publication: | 2023 |
Language: | English |
Physical Description: | 1 online resource (308 pages) |
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Casamassimi, Amelia, author. Transcriptional Regulation and Its Misregulation in Human Diseases / Amelia Casamassimi, Alfredo Ciccodicola, Monica Rienzo. Basel : MDPI - Multidisciplinary Digital Publishing Institute, 2023. 1 online resource (308 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Description based on online resource; title from PDF title page (MDPI - Multidisciplinary Digital Publishing Institute, viewed July 29, 2023). Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extracellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity. This control involves multiple temporal and functional steps as well as innumerable molecules including transcription factors, cofactors, and chromatin regulators. It is well known that many human disorders are characterized by global transcriptional dysregulation because most of the signaling pathways ultimately target transcription machinery. Indeed, many syndromes and genetic and complex diseases--cancer, autoimmunity, neurological and developmental disorders, and metabolic and cardiovascular diseases--can be caused by mutations/alterations in regulatory sequences, transcription factors, splicing regulators, cofactors, chromatin regulators, ncRNAs, and other components of transcription apparatus. It is worth noting that advances in our understanding of molecules and mechanisms involved in the transcriptional circuitry and apparatus lead to new insights into the pathogenetic mechanisms of various human diseases and disorders. Thus, this Special Issue is focused on molecular genetics and genomics studies exploring the effects of transcriptional misregulation on human diseases. Genetic regulation. 3-0365-7736-X Ciccodicola, Alfredo, author. Rienzo, Monica, author. |
language |
English |
format |
eBook |
author |
Casamassimi, Amelia, Ciccodicola, Alfredo, Rienzo, Monica, |
spellingShingle |
Casamassimi, Amelia, Ciccodicola, Alfredo, Rienzo, Monica, Transcriptional Regulation and Its Misregulation in Human Diseases / |
author_facet |
Casamassimi, Amelia, Ciccodicola, Alfredo, Rienzo, Monica, Ciccodicola, Alfredo, Rienzo, Monica, |
author_variant |
a c ac a c ac m r mr |
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VerfasserIn VerfasserIn VerfasserIn |
author2 |
Ciccodicola, Alfredo, Rienzo, Monica, |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Casamassimi, Amelia, |
title |
Transcriptional Regulation and Its Misregulation in Human Diseases / |
title_full |
Transcriptional Regulation and Its Misregulation in Human Diseases / Amelia Casamassimi, Alfredo Ciccodicola, Monica Rienzo. |
title_fullStr |
Transcriptional Regulation and Its Misregulation in Human Diseases / Amelia Casamassimi, Alfredo Ciccodicola, Monica Rienzo. |
title_full_unstemmed |
Transcriptional Regulation and Its Misregulation in Human Diseases / Amelia Casamassimi, Alfredo Ciccodicola, Monica Rienzo. |
title_auth |
Transcriptional Regulation and Its Misregulation in Human Diseases / |
title_new |
Transcriptional Regulation and Its Misregulation in Human Diseases / |
title_sort |
transcriptional regulation and its misregulation in human diseases / |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute, |
publishDate |
2023 |
physical |
1 online resource (308 pages) |
isbn |
3-0365-7736-X |
callnumber-first |
Q - Science |
callnumber-subject |
QH - Natural History and Biology |
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QH 3450 C373 42023 |
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Not Illustrated |
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500 - Science |
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570 - Life sciences; biology |
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572 - Biochemistry |
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572.865 |
dewey-sort |
3572.865 |
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572.865 |
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572.865 |
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Transcriptional Regulation and Its Misregulation in Human Diseases / |
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