Role of Toll-Like Receptors (TLR) in Infection and Inflammation / / Ralf Kircheis, Oliver Planz.
Toll-like receptors (TLRs) represent a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. Typical PAMPs include bacterial cell wa...
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Place / Publishing House: | Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, 2023. |
Year of Publication: | 2023 |
Language: | English |
Physical Description: | 1 online resource (236 pages) |
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Kircheis, Ralf, author. Role of Toll-Like Receptors (TLR) in Infection and Inflammation / Ralf Kircheis, Oliver Planz. Role of Toll-Like Receptors Basel : MDPI - Multidisciplinary Digital Publishing Institute, 2023. 1 online resource (236 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Description based on online resource; title from PDF title page (MDPI - Multidisciplinary Digital Publishing Institute, viewed July 29, 2023). Toll-like receptors (TLRs) represent a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. Typical PAMPs include bacterial cell wall components, viral pathogens, or pathogenic nucleic acids, including viral RNA and DNA. Activation of TLRs leads to the production of proinflammatory cytokines and type I interferons which are important for the induction of the host immune response against bacterial and viral infections. However, dysregulation and overstimulation can be detrimental, leading to hyper-inflammation, sepsis, and loss of tissue integrity. The involvement of TLRs in inflammation and bacterial infection has been recognized for a long time. There is an increasing number of reports demonstrating the involvement of TLR activation in a variety of viral infections, associated with protective immunity, but also immune hyper activation and even viral replication. Recent data show the involvement of TLR activation in various acute respiratory viral infections, including SARS-CoV-2 and indicate an essential role in COVID-19 pathology. It aimed to gather newest data and hypotheses regarding molecular and cellular mechanisms of TLR triggering and activation and their downstream signaling pathways by viral infections, and their correlation to immunology and pathophysiology of the associated diseases, to facilitate translational research resulting in new targets for the treatment of viral infectious diseases including COVID-19. Cell receptors. 3-0365-7614-2 Planz, Oliver, author. |
language |
English |
format |
eBook |
author |
Kircheis, Ralf, Planz, Oliver, |
spellingShingle |
Kircheis, Ralf, Planz, Oliver, Role of Toll-Like Receptors (TLR) in Infection and Inflammation / |
author_facet |
Kircheis, Ralf, Planz, Oliver, Planz, Oliver, |
author_variant |
r k rk o p op |
author_role |
VerfasserIn VerfasserIn |
author2 |
Planz, Oliver, |
author2_role |
TeilnehmendeR |
author_sort |
Kircheis, Ralf, |
title |
Role of Toll-Like Receptors (TLR) in Infection and Inflammation / |
title_full |
Role of Toll-Like Receptors (TLR) in Infection and Inflammation / Ralf Kircheis, Oliver Planz. |
title_fullStr |
Role of Toll-Like Receptors (TLR) in Infection and Inflammation / Ralf Kircheis, Oliver Planz. |
title_full_unstemmed |
Role of Toll-Like Receptors (TLR) in Infection and Inflammation / Ralf Kircheis, Oliver Planz. |
title_auth |
Role of Toll-Like Receptors (TLR) in Infection and Inflammation / |
title_alt |
Role of Toll-Like Receptors |
title_new |
Role of Toll-Like Receptors (TLR) in Infection and Inflammation / |
title_sort |
role of toll-like receptors (tlr) in infection and inflammation / |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute, |
publishDate |
2023 |
physical |
1 online resource (236 pages) |
isbn |
3-0365-7614-2 |
callnumber-first |
Q - Science |
callnumber-subject |
QH - Natural History and Biology |
callnumber-label |
QH603 |
callnumber-sort |
QH 3603 C43 K573 42023 |
illustrated |
Not Illustrated |
dewey-hundreds |
500 - Science |
dewey-tens |
570 - Life sciences; biology |
dewey-ones |
574 - [Unassigned] |
dewey-full |
574.875 |
dewey-sort |
3574.875 |
dewey-raw |
574.875 |
dewey-search |
574.875 |
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Role of Toll-Like Receptors (TLR) in Infection and Inflammation / |
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