A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus : : Molecular and cellular alterations underlying memory impairments in animal models of neurodegeneration / / Daniele Lana.
Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the patho...
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| Superior document: | Premio Tesi di dottorato |
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| VerfasserIn: | |
| Place / Publishing House: | Firenze, Italy : : Firenze University Press,, [2015] ©2015 |
| Year of Publication: | 2015 |
| Language: | English |
| Series: | Premio Tesi di dottorato.
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| Physical Description: | 1 online resource (136 pages) :; illustrations. |
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| Other title: | Study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus |
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| Summary: | Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the pathophysiological processes at the base of the cognitive impairments in different experimental models of neurodegeneration: in particular normal brain aging, neuroinfiammation and chronic cerebral hypoperfusion. These mechanisms are studied focusing on the morpho-functional alterations in the neuron-astrocytemicroglia triad. |
| Access: | Open access |
| Hierarchical level: | Monograph |
| Statement of Responsibility: | Daniele Lana. |