Regulation of chemokine-receptor interactions and functions / / edited by Martin J. Stone.

• TeilnehmendeR: Stone, Martin J.,
• Place / Publishing House: Basel, Switzerland : : MDPI,, 2018.
• Year of Publication: 2018
• Language: English
• Physical Description: 1 online resource (v, 228 pages) :; illustrations

A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the discovery of chemokines (chemotactic cytokines), a family of small, secreted proteins that induce migration of selective subsets of leukocytes. Shortly afterwards, chemokines were found to exert their functions through the now familiar chemokine receptors, members of the G protein-coupled receptor superfamily. As their physiological and pathological functions were elucidated, chemokine receptors have become popular targets for drug development in inflammatory diseases as well as cancer metastasis and HIV infection. Extensive research has revealed that the functions of chemokines and their receptors are regulated at numerous levels, including: genetic mutations/polymorphisms; control of expression levels; ligand internalization via functional or decoy receptors; intrinsic selectivity of chemokine-receptor binding; hetero- or homo-oligomerization of chemokines or of receptors; alternative signalling pathways; interaction of chemokines with glycosaminoglycans; post-translational modifications; and binding to pathogen-derived inhibitors. This Special Issue of IJMS focused on the natural and pharmacological mechanisms by which the activities of chemokines and their receptors can be regulated.

Table of Contents

About the Special Issue Editor -- Martin J. Stone Regulation of Chemokine-Receptor Interactions and Functions, doi: 10.3390/ijms18112415 -- Martin J. Stone, Jenni A. Hayward, Cheng Huang, Zil E. Huma and Julie Sanchez Mechanisms of Regulation of the Chemokine-Receptor Network doi: 10.3390/ijms18020342 -- Michelle C. Miller and Kevin H. Mayo Chemokines from a Structural Perspective doi: 10.3390/ijms18102088 -- Sarah Thompson, Beatriz Martnez-Burgo, Krishna Mohan Sepuru, Krishna Rajarathnam, John A. Kirby, Neil S. Sheerin and Simi Ali Regulation of Chemokine Function: The Roles of GAG-Binding and Post-Translational Nitration doi: 10.3390/ijms18081692 -- Aaron J. Brown, Krishna Mohan Sepuru and Krishna Rajarathnam Structural Basis of Native CXCL7 Monomer Binding to CXCR2 Receptor N-Domain and Glycosaminoglycan Heparin doi: 10.3390/ijms18030508 -- Aaron J. Brown, Prem Raj B. Joseph, Kirti V. Sawant and Krishna Rajarathnam Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions doi: 10.3390/ijms18040748 -- Mieke Metzemaekers, Anneleen Mortier, Rik Janssens, Daiane Boff, Lotte Vanbrabant, Nicole Lamoen, Jo Van Damme, Mauro M. Teixeira, Ingrid De Meester, Flvio A. Amaral and Paul Proost Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling doi: 10.3390/ijms18071513 -- Anna F. Nguyen, Megan S. Schill, Mike Jian and Patricia J. LiWang The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES doi: 10.3390/ijms18071575 -- Natasha A. Moussouras, Anthony E. Getschman, Emily R. Lackner, Christopher T. Veldkamp, Michael B. Dwinell and Brian F. Volkman Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands doi: 10.3390/ijms18091894 -- Andrew J. Phillips, Deni Taleski, Chad A. Koplinski, Anthony E. Getschman, Natasha A. Moussouras, Amanda M. Richard, Francis C. Peterson, Michael B. Dwinell, Brian F. Volkman, Richard J. Payne and Christopher T. Veldkamp CCR7 Sulfotyrosine Enhances CCL21 Binding doi: 10.3390/ijms18091857 -- Vivian Adamski, Rolf Mentlein, Ralph Lucius, Michael Synowitz, Janka Held-Feindt and Kirsten Hattermann The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16 doi: 10.3390/ijms18071468 -- Anna F. Nguyen, Nai-Wei Kuo, Laura J. Showalter, Ricardo Ramos, Cynthia M. Dupureur, Michael E. Colvin and Patricia J. LiWang Biophysical and Computational Studies of the VCCI:VMIP-II Complex doi: 10.3390/ijms18081778 Ryosuke Sakumoto, Ken-Go Hayashi, Shiori Fujii, Hiroko Kanahara, Misa Hosoe, Tadashi Furusawa and Keiichiro Kizaki Possible Roles of CC- and CXC-Chemokines in Regulating Bovine Endometrial Function during Early Pregnancy doi: 10.3390/ijms18040742.