Marine compounds and cancer / / edited by Friedemann Honecker, Sergey A. Dyshlovoy.

• TeilnehmendeR: Honecker, Friedemann,; Dyshlovoy, Sergey A.,
• Place / Publishing House: Basel, Switzerland : : MDPI,, 2018.
• Year of Publication: 2018
• Language: English
• Physical Description: 1 online resource (118 pages)

The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U(R)), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.

Table of Contents

About the Special Issue Editors -- Sergey A. Dyshlovoy and Friedemann Honecker Marine Compounds and Cancer: 2017 Updates doi: 10.3390/md16020041 -- Beatriz Martínez-Poveda, Ana R. Quesada and Miguel Ángel Medina Pleiotropic Role of Puupehenones in Biomedical Research doi: 10.3390/md15100325 -- Aida Sarmiento-Vizcaíno, Alfredo F. Braña, Ignacio Pérez-Victoria, Jesús Martín, Nuria de Pedro, Mercedes de la Cruz, Caridad Díaz, Francisca Vicente, José L. Acua, Fernando Reyes, Luis A. Garca and Gloria Blanco Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea doi: 10.3390/md15090271 -- Julia Sperlich, Russell Kerr and Nicole Teusch The Marine Natural Product Pseudopterosin Blocks Cytokine Release of Triple-Negative Breast Cancer and Monocytic Leukemia Cells by Inhibiting NF-kB Signaling doi: 10.3390/md15090262 -- Xian Sun, Yu Zhong, Hongtian Luo and Yufeng Yang Selenium-Containing Polysaccharide-Protein Complex in Se-Enriched Ulva fasciata Induces Mitochondria-Mediated Apoptosis in A549 Human Lung Cancer Cells doi: 10.3390/md15070215 -- Lan-Ting Xin, Lu Liu, Chang-Lun Shao, Ri-Lei Yu, Fang-Ling Chen, Shi-Jun Yue, Mei Wang, Zhong-Long Guo, Ya-Chu Fan, Hua-Shi Guan and Chang-Yun Wang Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products doi: 10.3390/md15070217 -- Michaela Dithmer, Anna-Maria Kirsch, Elisabeth Richert, Sabine Fuchs, Fanlu Wang, Harald Schmidt, Sarah E. Coupland, Johann Roider and Alexa Klettner Fucoidan Does Not Exert Anti-Tumorigenic Effects on Uveal Melanoma Cell Lines doi: 10.3390/md15070193 -- Mohamed-Elamir F. Hegazy, Abdelsamed I. Elshamy, Tarik A. Mohamed, Ahmed R. Hamed, Mahmoud A. A. Ibrahim, Shinji Ohta and Paul W. Paré Cembrene Diterpenoids with Ether Linkages from Sarcophyton ehrenbergi: An Anti- Proliferation and Molecular-Docking Assessment doi: 10.3390/md15060192 -- Tanja Schirmeister, Swarna Oli, Hongmei Wu, Gerardo Della Sala, Valeria Costantino, Ean-Jeong Seo and Thomas Efferth Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation doi: 10.3390/md15030063 -- Xinya Xu, Xiaoyong Zhang, Xuhua Nong, Jie Wang and Shuhua Qi Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025 doi: 10.3390/md15020043.