Drug-acceptor interactions : : modeling theoretical tools to test and evaluate experimental equilibrium effects /

Drug-acceptor interactions : : modeling theoretical tools to test and evaluate experimental equilibrium effects / / Niels Bindslev.

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Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools f...

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Bibliographic Details
VerfasserIn:
Bindslev, Niels,
Place / Publishing House:[Place of publication not identified] : : Taylor & Francis,, 2008.
Year of Publication:2008
Language:English
Physical Description:1 online resource (xviii, 410 pages)
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Table of Contents:
  • Part I ONE-STATE MODELS: SIMPLE AGONISM AND ANT-AGONISM
  • CHAPTER 1 Simple agonism
  • CHAPTER 2 Simple ant-agonism simple intervention
  • CHAPTER 3 Auto-inhibition and auto-intervention in one-state models
  • CHAPTER 4 Means of obtaining ant-agonist constants: Preliminary points of a personal view
  • Part II TWO-STATE MODELS: COMPLEX AGONISM AND MODULATION
  • CHAPTER 5 Complex agonism
  • CHAPTER 6 Multi-step reaction schemes: extending the two-step mechanism of del Castillo and Katz
  • CHAPTER 7 Cubic reaction schemes. ATSM and HOTSM
  • Part III TEST OF TOOLS FOR DATA ANALYSIS
  • CHAPTER 8 Choosing and formulating relevant schemes
  • CHAPTER 9 Plots, fits and data interpretation.
  • CHAPTER 10 Hill in hell
  • CHAPTER 11 The Schild against other theories
  • CHAPTER 12 Ties between synergy and two-state models
  • Part IV BIOLOGICAL REGULATION AND ALLOSTERY
  • CHAPTER 13 Strategies of biological regulation
  • CHAPTER 14 On allostery and co-operativity
  • CHAPTER 15 Allostery and development of its models.

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