The fungal cell wall integrity pathway / / María Molina, Humberto Martín [editors].

• TeilnehmendeR: Martín, Humberto ,; Molina, María ,
• Place / Publishing House: Basel : : MDPI,, [2023]; ©2023
• Year of Publication: 2023
• Language: English
• Physical Description: 1 online resource

Adaptation to external changes is necessary for all cells to survive and thrive in diverse environments. Key to these responses are the MAPK-mediated signaling pathways, intracellular communication routes that sense stimuli at the cell surface, and are ubiquitous in all eukaryotic organisms. In the case of fungi, MAPKs mediate essential processes, such as adaptation to environmental stresses, morphology regulation, or developmental processes. First studied in the early nineties in Saccharomyces cerevisiae, the fungal cell wall integrity (CWI) pathway has proven to be a central MAPK-mediated signaling cascade conserved in the fungal kingdom. Cells need to sense cell wall-perturbing conditions and mount the appropriate salvage response. Understanding this CWI pathway-mediated compensatory mechanism is key for the development of cell wall-targeted antifungal therapies. Moreover, its functional roles go beyond the maintenance of this essential structure, reaching many other physiological aspects that have major implications in development or virulence. In this Special Issue, expert researchers in this relevant subject have contributed with seven reviews and eleven original articles to advance our understanding of the CWI pathway by covering different structural, regulatory, and functional aspects in distinct yeasts and filamentous fungi.

Table of Contents

About the Editors vii -- Humberto Mart´ın and Mar´ıa Molina -- Special Issue "The Fungal Cell Wall Integrity Pathway" -- Reprinted from: J. Fungi 2023, 9, 293, doi:10.3390/jof9030293 1 -- Akira Yoshimi, Ken Miyazawa, Moriyuki Kawauchi and Keietsu Abe -- Cell Wall Integrity and Its Industrial Applications in Filamentous Fungi -- Reprinted from: J. Fungi 2022, 8, 435, doi:10.3390/jof8050435 7 -- Chibuike Ibe and Carol A. Munro -- Fungal Cell Wall Proteins and Signaling Pathways Form a Cytoprotective Network to Combat -- Stresses -- Reprinted from: J. Fungi 2021, 7, 739, doi:10.3390/jof7090739 31 -- Haroldo Cesar de Oliveira, Suelen Andreia Rossi, Irene Garc´ıa-Barbaz ´an, Oscar Zaragoza ´ -- and Nuria Trevijano-Contador -- Cell Wall Integrity Pathway Involved in Morphogenesis, Virulence and Antifungal -- Susceptibility in Cryptococcus neoformans -- Reprinted from: J. Fungi 2021, 7, 831, doi:10.3390/jof7100831 55 -- Gema Gonz´alez-Rubio, Luc´ıa Sastre-Vergara, Mar´ıa Molina, Humberto Mart´ın and Teresa -- Fern ´andez-Acero -- Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity -- Reprinted from: J. Fungi 2022, 8, 368, doi:10.3390/jof8040368 67 -- Jos ´e Cansado, Teresa Soto, Alejandro Franco, Jero Vicente-Soler and Marisa Madrid -- The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and -- Beyond -- Reprinted from: J. Fungi 2021, 8, 32, doi:10.3390/jof8010032 93 -- Inma Quilis, Merc`e Gomar-Alba and Juan Carlos Igual -- The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression -- Reprinted from: J. Fungi 2021, 7, 1041, doi:10.3390/jof7121041 125 -- Cesar Roncero, Rub´en Celador, Noelia S´anchez, Patricia Garc´ıa and Yolanda S´anchez -- The Role of the Cell Integrity Pathway in Septum Assembly in Yeast -- Reprinted from: J. Fungi 2021, 7, 729, doi:10.3390/jof7090729 147 -- Philipp Sch ¨oppner, Anne Pia Lutz, Bernard Johannes Lutterbach, Stefan Br ¨uckner, -- Lars-Oliver Essen and Hans-Ulrich M ¨osch -- Structure of the Yeast Cell Wall Integrity Sensor Wsc1 Reveals an Essential Role of -- Surface-Exposed Aromatic Clusters -- Reprinted from: J. Fungi 2022, 8, 379, doi:10.3390/jof8040379 165 -- Natalia Voskoboynikova, Maria Karlova, Rainer Kurre, Armen Y. Mulkidjanian, Konstantin -- V. Shaitan and Olga S. Sokolova et al. -- A Three-Dimensional Model of the Yeast Transmembrane Sensor Wsc1 Obtained by SMA-Based -- Detergent-Free Purification and Transmission Electron Microscopy -- Reprinted from: J. Fungi 2021, 7, 118, doi:10.3390/jof7020118 183 -- Allison E. Hall, Miriam Lisci and Mark D. Rose -- Differential Requirement for the Cell Wall Integrity Sensor Wsc1p in Diploids Versus Haploids -- Reprinted from: J. Fungi 2021, 7, 1049, doi:10.3390/jof7121049 201 -- Sandra Montella-Manuel, Nuria Pujol-Carrion and Maria Angeles de la Torre-Ruiz -- The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When -- Glucose Availability Is Compromised -- Reprinted from: J. Fungi 2021, 7, 903, doi:10.3390/jof7110903 219 -- Li Liu, Jiri Veis, Wolfgang Reiter, Edwin Motari, Catherine E. Costello and John C. -- Samuelson et al. -- Regulation of Pkc1 Hyper-Phosphorylation by Genotoxic Stress -- Reprinted from: J. Fungi 2021, 7, 874, doi:10.3390/jof7100874 245 -- Angela Sellers-Moya, Marcos Nu´evalos, Mar´ıa Molina and Humberto Mart´ın ´ -- Clotrimazole-Induced Oxidative Stress Triggers Novel Yeast Pkc1-Independent Cell Wall -- Integrity MAPK Pathway Circuitry -- Reprinted from: J. Fungi 2021, 7, 647, doi:10.3390/jof7080647 263 -- Isabel E. S´anchez-Adri´a, Gemma Sanmart´ın, Jose A. Prieto, Francisco Estruch and Francisca -- Randez-Gil -- Slt2 Is Required to Activate ER-Stress-Protective Mechanisms through TORC1 Inhibition and -- Hexosamine Pathway Activation -- Reprinted from: J. Fungi 2022, 8, 92, doi:10.3390/jof8020092 285 -- Ana Bel ´en Sanz, Sonia D´ıez-Mu ˜niz, Jennifer Moya, Yuliya Petryk, C´esar Nombela and Jos ´e -- M. Rodr´ıguez-Pe ˜na et al. -- Systematic Identification of Essential Genes Required for Yeast Cell Wall Integrity: Involvement -- of the RSC Remodelling Complex -- Reprinted from: J. Fungi 2022, 8, 718, doi:10.3390/jof8070718 307 -- Farzan Ghanegolmohammadi, Hiroki Okada, Yaxuan Liu, Kaori Itto-Nakama, Shinsuke -- Ohnuki and Anna Savchenko et al. -- Defining Functions of Mannoproteins in Saccharomyces cerevisiae by High-Dimensional -- Morphological Phenotyping -- Reprinted from: J. Fungi 2021, 7, 769, doi:10.3390/jof7090769 325 -- Marina Valente Navarro, Yasmin Nascimento de Barros, Wilson Dias Segura, Alison Felipe -- Alencar Chaves, Grasielle Pereira Jannuzzi and Karen Spadari Ferreira et al. -- The Role of Dimorphism Regulating Histidine Kinase (Drk1) in the Pathogenic Fungus -- Paracoccidioides brasiliensis Cell Wall -- Reprinted from: J. Fungi 2021, 7, 1014, doi:10.3390/jof7121014 345 -- Elisa G ´omez-Gil, Alejandro Franco, Beatriz V ´azquez-Mar´ın, Francisco Prieto-Ruiz, Armando -- P ´erez-D´ıaz and Jero Vicente-Soler et al. -- Specific Functional Features of the Cell Integrity MAP Kinase Pathway in the Dimorphic Fission -- Yeast Schizosaccharomyces japonicus -- Reprinted from: J. Fungi 2021, 7, 482, doi:10.3390/jof7060482 65.