Molecular Mechanism and Application of Somatic Cell Cloning in Mammals / / edited by Marcin Samiec, Maria Skrzyszowska.

• TeilnehmendeR: Samiec, Marcin,; Skrzyszowska, Maria,
• Place / Publishing House: [Place of publication not identified] : : MDPI - Multidisciplinary Digital Publishing Institute,, 2023.
• Year of Publication: 2023
• Language: English
• Physical Description: 1 online resource (244 pages)

The primary objective of this book is to provide the current status of and new data on the molecular mechanisms affecting the efficacy of somatic cell cloning, but also insightful interpretations of the topical and coming trends in the exploration of genomic, epigenomic, transcriptomic and proteomic profiles for nuclear donor cells, nuclear recipient oocytes and SCNT-derived embryos. Comprehensively deciphering the crucial molecular scenarios responsible for inter-genomic, inter-epigenomic, inter-transcriptomic and inter-proteomic communication within the framework of the aforementioned scenarios might be a milestone giving rise to the enhancements in the extra- and intracorporeal epigenetic reprogrammabilities of donor cell nuclei in nuclear-transferred oocytes, embryos, conceptuses and neonates. In turn, this might allow us to use SCNT-mediated ARTs in such research fields as biotechnology, transgenics, medicine, and biopharmacology, as well as scientific efforts targeted at designing the in vitro and in vivo models of molecular and epigenomic landscapes specific for inheritable and acquired disorders in humans and other mammalian species.

Table of Contents

About the Editors vii -- Preface to "Molecular Mechanism and Application of Somatic Cell Cloning in Mammals" ix -- Marcin Samiec Molecular Mechanism and Application of Somatic Cell Cloning in Mammals-Past, Present and Future Reprinted from: Int. J. Mol. Sci. 2022, 23, 13786, doi:10.3390/ijms232213786 . 1 -- Marcin Samiec and Maria Skrzyszowska Extranuclear Inheritance of Mitochondrial Genome and Epigenetic Reprogrammability of Chromosomal Telomeres in Somatic Cell Cloning of Mammals Reprinted from: Int. J. Mol. Sci. 2021, 22, 3099, doi:10.3390/ijms22063099 7 -- Maria Skrzyszowska and Marcin Samiec Generating Cloned Goats by Somatic Cell Nuclear Transfer-Molecular Determinants and Application to Transgenics and Biomedicine Reprinted from: Int. J. Mol. Sci. 2021, 22, 7490, doi:10.3390/ijms22147490 33 -- Marcin Samiec, Jerzy Wiater, Kamil Wartalski, Maria Skrzyszowska, Monika Trzci ´nska and Daniel Lipi ´nski et al. The Relative Abundances of Human Leukocyte Antigen-E, α-Galactosidase A and α-Gal Antigenic Determinants Are Biased by Trichostatin A-Dependent Epigenetic Transformation of Triple-Transgenic Pig-Derived Dermal Fibroblast Cells Reprinted from: Int. J. Mol. Sci. 2022, 23, 10296, doi:10.3390/ijms231810296 . 49 -- Jerzy Wiater, Marcin Samiec, Kamil Wartalski, Zdzisław Smorag, Jacek Jura and Ryszard Słomski et al. Characterization of Mono- and Bi-Transgenic Pig-Derived Epidermal Keratinocytes Expressing Human FUT2 and GLA Genes-In Vitro Studies Reprinted from: Int. J. Mol. Sci. 2021, 22, 9683, doi:10.3390/ijms22189683 69 -- Gabriela Gorczyca, Kamil Wartalski, Jerzy Wiater, Marcin Samiec, Zbigniew Tabarowski and Małgorzata Duda Anabolic Steroids-Driven Regulation of Porcine Ovarian Putative Stem Cells Favors the Onset of Their Neoplastic Transformation Reprinted from: Int. J. Mol. Sci. 2021, 22, 11800, doi:10.3390/ijms222111800 . 87 -- Yong-ho Choe, Tai-Young Hur, Sung-Lim Lee, Seunghoon Lee, Dajeong Lim and Bong-Hwan Choi et al. Brachygnathia Inferior in Cloned Dogs Is Possibly Correlated with Variants of Wnt Signaling Pathway Initiators Reprinted from: Int. J. Mol. Sci. 2022, 23, 475, doi:10.3390/ijms23010475 111 -- Gabriela Gorczyca, Kamil Wartalski, Marek Romek, Marcin Samiec and Małgorzata Duda The Molecular Quality and Mitochondrial Activity of Porcine Cumulus-Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions Reprinted from: Int. J. Mol. Sci. 2022, 23, 4572, doi:10.3390/ijms23094572 141 -- Przemysław Podstawski, Marcin Samiec, Maria Skrzyszowska, Tomasz Szmatoła, Ewelina Semik-Gurgul and Katarzyna Ropka-Molik The Induced Expression of BPV E4 Gene in Equine Adult Dermal Fibroblast Cells as a Potential Model of Skin Sarcoid-like Neoplasia Reprinted from: Int. J. Mol. Sci. 2022, 23, 1970, doi:10.3390/ijms23041970 177 -- Przemysław Podstawski, Katarzyna Ropka-Molik, Ewelina Semik-Gurgul, Marcin Samiec, Maria Skrzyszowska and Zenon Podstawski et al. Tracking the Molecular Scenarios for Tumorigenic Remodeling of Extracellular Matrix Based on Gene Expression Profiling in Equine Skin Neoplasia Models Reprinted from: Int. J. Mol. Sci. 2022, 23, 6506, doi:10.3390/ijms23126506 201 -- Tomasz Zabek, Wojciech Witarski, Tomasz Szmatoła, Sebastian Sawicki, Justyna Mrozowicz and Marcin Samiec Trichostatin A-Mediated Epigenetic Modulation Predominantly Triggers Transcriptomic Alterations in the Ex Vivo Expanded Equine Chondrocytes Reprinted from: Int. J. Mol. Sci. 2022, 23, 13168, doi:10.3390/ijms232113168 . 217.