Molecular Mechanisms and Therapies of Colorectal Cancer / / edited by Donatella Delle Cave, Alessandro Ottaiano.

• TeilnehmendeR: Cave, Donatella Delle,; Ottaiano, Alessandro,
• Place / Publishing House: [Place of publication not identified] : : MDPI - Multidisciplinary Digital Publishing Institute,, 2023.
• Year of Publication: 2023
• Language: English
• Physical Description: 1 online resource (294 pages)

Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality, with 1.9 million incidence cases and 0.9 million deaths worldwide. The global number of new CRC cases is predicted to reach 3.2 million in 2040, based on the projection of aging, population growth, and human development. In clinics, despite advances of diagnosis and surgical procedures, 20% of the patients with CRC present with metastasis at the time of diagnosis, caused by residual tumor cells that have spread to distant organs prior to surgery, affecting the patient survival rate. Standard systemic chemotherapy, alternative therapies that target mechanisms involved in cancer progression and metastasis, immunotherapy, and combination therapies are the major CRC-treatment strategies. In the advanced stage of CRC the transforming growth factor-beta (TGF-β) plays an oncogenic role by promoting cancer cell proliferation, cancer cell self-renewal, epithelial-to-mesenchymal transition, invasion, tumor progression, metastatic spread, and immune escape. Furthermore, high levels of TGF-β1 confers poor prognosis and is associated with early recurrence after surgery, resistance to chemo- or immunotherapy, and shorter survival. Based on the body of experimental evidence indicating that TGF-β signaling has the potential to be a good therapeutic target in CRC, several anti-TGF-β drugs have been investigated in cancer clinical trials. Here, we presented a comprehensive collection of manuscripts regarding studies on targeting the TGF-β signaling in CRC to improve patient's prognosis and personalized treatments.

Table of Contents

Aurora Gazzillo, Michela Anna Polidoro, Cristiana Soldani, Barbara Franceschini, Ana Lleo and Matteo Donadon Relationship between Epithelial-to-Mesenchymal Transition and Tumor-Associated Macrophages in Colorectal Liver Metastases Reprinted from: Int. J. Mol. Sci. 2022, 23, 16197, doi:10.3390/ijms232416197 . 1 -- Viktoria Bekusova, Tatiana Zudova, Ilyas Fatyykhov, Arina Fedorova, Salah Amasheh and Alexander G. Markov Selective Role of TNF and IL10 in Regulation of Barrier Properties of the Colon in DMH-Induced Tumor and Healthy Rats Reprinted from: Int. J. Mol. Sci. 2022, 23, 15610, doi:10.3390/ijms232415610 . 21 -- Xiaoshuang Li, Yanmin Wu and Tian Tian TGF-β Signaling in Metastatic Colorectal Cancer (mCRC): From Underlying Mechanism to Potential Applications in Clinical Development Reprinted from: Int. J. Mol. Sci. 2022, 23, 14436, doi:10.3390/ijms232214436 . 35 -- Muhammad G Kibriya, Maruf Raza, Anthony Quinn, Mohammed Kamal, Habibul Ahsan and Farzana Jasmine A Transcriptome and Methylome Study Comparing Tissues of Early and Late Onset Colorectal Carcinoma Reprinted from: Int. J. Mol. Sci. 2022, 23, 14261, doi:10.3390/ijms232214261 . 63 -- Jean Mazella Deciphering Mechanisms of Action of Sortilin/Neurotensin Receptor-3 in the Proliferation Regulation of Colorectal and Other Cancers Reprinted from: Int. J. Mol. Sci. 2022, 23, 11888, doi:10.3390/ijms231911888 . 85 -- Nurul Nadirah Razali, Raja Affendi Raja Ali, Khairul Najmi Muhammad Nawawi, Azyani Yahaya and Norfilza M. Mokhtar Targeted Sequencing of Cytokine-Induced PI3K-Related Genes in Ulcerative Colitis, Colorectal Cancer and Colitis-Associated Cancer Reprinted from: Int. J. Mol. Sci. 2022, 23, 11472, doi:10.3390/ijms231911472 . 97 -- Luigi Borzacchiello, Roberta Veglia Tranchese, Roberta Grillo, Roberta Arpino, Laura Mosca and Giovanna Cacciapuoti et al. S-Adenosylmethionine Inhibits Colorectal Cancer Cell Migration through Mirna-Mediated Targeting of Notch Signaling Pathway Reprinted from: Int. J. Mol. Sci. 2022, 23, 7673, doi:10.3390/ijms23147673 113 -- Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Imilia Ismail, Learn-Han Lee and Nurul Syakima Ab Mutalib MicroRNA Methylome Signature and Their Functional Roles in Colorectal Cancer Diagnosis, Prognosis, and Chemoresistance Reprinted from: Int. J. Mol. Sci. 2022, 23, 7281, doi:10.3390/ijms23137281 133 -- James Drury, Lyndsay E. A. Young, Timothy L. Scott, Courtney O. Kelson, Daheng He and Jinpeng Liu et al. Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer Reprinted from: Int. J. Mol. Sci. 2022, 23, 6510, doi:10.3390/ijms23126510 149 -- v Giorgia Moriondo, Giulia Scioscia, Piera Soccio, Pasquale Tondo, Cosimo Carlo De Pace and Roberto Sabato et al. Effect of Hypoxia-Induced Micro-RNAs Expression on Oncogenesis Reprinted from: Int. J. Mol. Sci. 2022, 23, 6294, doi:10.3390/ijms23116294 171 -- Geoffrey Yuet Mun Wong, Connie Diakos, Thomas J. Hugh and Mark P. Molloy Proteomic Profiling and Biomarker Discovery in Colorectal Liver Metastases Reprinted from: Int. J. Mol. Sci. 2022, 23, 6091, doi:10.3390/ijms23116091 181 -- Georgina E. Riddiough, Katrina A. Walsh, Theodora Fifis, Georgios Kastrappis, Bang M. Tran and Elizabeth Vincan et al. Captopril, a Renin-Angiotensin System Inhibitor, Attenuates Tumour Progression in the Regenerating Liver Following Partial Hepatectomy Reprinted from: Int. J. Mol. Sci. 2022, 23, 5281, doi:10.3390/ijms23095281 201 -- Marcel Smid, Saskia M. Wilting and John W. M. Martens Lost by Transcription: Fork Failures, Elevated Expression, and Clinical Consequences Related to Deletions in Metastatic Colorectal Cancer Reprinted from: Int. J. Mol. Sci. 2022, 23, 5080, doi:10.3390/ijms23095080 215 -- Eirini Martinou, Carla Moller-Levet, Dimitrios Karamanis, Izhar Bagwan and Angeliki M. Angelidi HOXB9 Overexpression Promotes Colorectal Cancer Progression and Is Associated with Worse Survival in Liver Resection Patients for Colorectal Liver Metastases Reprinted from: Int. J. Mol. Sci. 2022, 23, 2281, doi:10.3390/ijms23042281 227 -- Andrea Santos, Ion Crist ´obal, Jaime Rubio, Cristina Caram´es, Melani Luque and Marta Sanz-Alvarez et al. MicroRNA-199b Deregulation Shows Oncogenic Properties and Promising Clinical Value as Circulating Marker in Locally Advanced Rectal Cancer Patients Reprinted from: Int. J. Mol. Sci. 2022, 23, 2203, doi:10.3390/ijms23042203 243 -- Brian G. Jorgensen and Seungil Ro MicroRNAs and 'Sponging' Competitive Endogenous RNAs Dysregulated in Colorectal Cancer: Potential as Noninvasive Biomarkers and Therapeutic Targets Reprinted from: Int. J. Mol. Sci. 2022, 23, 2166, doi:10.3390/ijms23042166 259.