Estrogen as a Contributing Factor to the Development of Lipedema / / written by Sara Al-Ghadban, Mary L. Teeler and Bruce A. Bunnell.

• VerfasserIn: Al-Ghadban, Sara,; Bunnell, Bruce A.,; Teeler, Mary L.,
• TeilnehmendeR: Bunnell, Bruce A.,; Teeler, Mary L.,
• Place / Publishing House: London : : IntechOpen,, 2021.
• Year of Publication: 2021
• Language: English
• Physical Description: 1 online resource (136 pages)

Lipedema is an underdiagnosed painful adipose tissue disorder that occurs almost exclusively in women, with onset manifesting at puberty or at times of hormonal change. Unlike many fat disorders, diet and exercise have little to no impact on the prevention or progression of this disease. Estrogens control the distribution of body fat and food intake, regulate leptin expression, increase insulin sensitivity, and reduce inflammation through signaling pathways mediated by its receptors, estrogen receptor alpha (ERα) and ERβ. This review will focus on understanding the role of estrogen in the pathogenesis of the disease and envisage potential hormonal therapy for lipedema patients.

Table of Contents

1. Introduction -- 2. Estrogens and estrogen receptors in lipedema -- 2.1 Estrogen and adipogenesis -- 2.2 Estrogen and inflammation -- 3. Potential hormonal therapy -- 4. Conclusion -- Acknowledgments -- Conflict of interest -- References.