Insights on Antimicrobial Peptides / / edited by Shymaa Enany, Jorge Masso-Silva, Anna Savitskaya.

• TeilnehmendeR: Enany, Shymaa,; Masso-Silva, Jorge,; Savitskaya, Anna,
• Place / Publishing House: London : : IntechOpen,, 2022.
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (166 pages)

Modern medicine is impossible without antibiotics, but global antibiotic usage has led to the development of increasing numbers of multi-drug resistant (MDR) bacteria. Thus, we still have problems with infectious disease treatment despite an arsenal of antibiotics. This has forced researchers to develop new drugs that will be effective against resistant bacteria. Some of these prospective molecules are antimicrobial peptides (AMPs), which are an important component of the innate immune system of various organisms in nature. Currently, more than 3,000 AMPs have been reported with different activities against different bacterial species including resistant phenotype bacteria. AMPs display remarkable structural and functional diversity that is not completely understood. As such, this book presents a comprehensive overview of AMPs and their mechanism of action against MDR bacteria.

Table of Contents

1. Introductory Chapter: Antimicrobial Peptides - Prodigious Therapeutic Strategies -- 2. Anti-Microbial Peptides: The Importance of Structure-Function Analysis in the Design of New AMPs -- 3. Antimicrobial Peptides: Mechanism of Action -- 4. Antimicrobial Peptides Derived from Ascidians and Associated Cyanobacteria -- 5. Molecular Pathogenesis of Inflammatory Cytokines in Insulin Resistance Diabetes Mellitus -- 6. Mass Spectrometry (Imaging) for Detection and Identification of Cyclic AMPs: Focus on Human Neutrophil Peptides (HNPs) -- 7. Cloning and Identification System of Apis mellifera Melittin cDNA in Escherichia coli -- 8. Peptides with Therapeutic Potential against Acinetobacter baumanii Infections.