Focus on Bacterial Biofilms / / edited by Theerthankar Das.

• TeilnehmendeR: Das, Theerthankar,
• Place / Publishing House: London : : IntechOpen,, 2022.
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (392 pages)

Bacterial biofilms are colonies of bacterial cells embedded in their self-produced matrix composed of polysaccharides, DNA, and proteins. They protect bacterial cells against antibiotics, antibacterial agents, soaps and detergents, and shear stress. Some of the most common biofilm-associated infections in humans include urinary tract infections, infection of wounds and surgical sites, diabetic foot ulcers, dental caries (tooth decay) and gingivitis (gum inflammation), ventilator-associated infections, sinusitis, microbial keratitis, secondary infection related to Covid-19 and other viral infections, and so on. Bacterial resistance to common antibiotics (e.g., penicillin, gentamycin, erythromycin, ciprofloxacin, etc.) is driving us to a catastrophic failure of our health systems. Strategies to develop novel antibacterial agents and technology must be prioritized to combat and eradicate biofilms and their associated challenges. This book provides a comprehensive overview of biofilms with chapters on bacterial virulence factors, quorum sensing in bacteria, antimicrobial resistance in bacteria, strategies to develop new antibacterial agents, and much more.

Table of Contents

1. Introductory Chapter: Highlighting Pros and Cons of Bacterial Biofilms -- 2. Bacterial Biofilm and the Medical Impact -- 3. Biofilm Formation by Pathogenic Bacteria: The Role of Quorum Sensing and Physical - Chemical Interactions -- 4. Biofilm and Quorum Sensing in Helicobacter pylori -- 5. Mechanism Involved in Biofilm Formation of Enterococcus faecalis -- 6. Biofilm Development in Gram-Positive and Gram-Negative Bacteria -- 7. Molecular Pathogenesis and Clinical Impact of Biofilms in Surgery -- 8. Bacterial Biofilm: Contribution to AMR and Approaches to Tackle -- -- 9. The Mechanisms of Bacterial Biofilm Inhibition and Eradication: The Search for Alternative Antibiofilm Agents -- 10. Approaches to Enhance Therapeutic Activity of Drugs against Bacterial Biofilms -- 11. Development of Antibiofilm Substances by Endophytic Microorganisms with an Emphasis on Medicine -- 12. Natural Products as Antibiofilm Agents -- 13. Efficacy of Radiations against Bacterial Biofilms -- 14. Antifouling Strategies-Interference with Bacterial Adhesion -- 15. Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect -- 16. Effect of Biofilm on Production of Poultry -- 17. Chronic Intraocular Leptospiral Infection Relying on Biofilm Formation inside the Vitreous Cavity Leads to Recurrent Uveitis in Horses -- 18. Sub-Aerial Cyanobacteria: A Survey of Research with Antimicrobial Properties for Pharmaceutical Approaches -- 19. Growing Environmental Bacterium Biofilms in PEO Cryogels for Environmental Biotechnology Application.