Scaffold Protein p140Cap as a Molecular Hub for Limiting Cancer Progression : : A New Paradigm in Neuroblastoma /

Scaffold Protein p140Cap as a Molecular Hub for Limiting Cancer Progression : : A New Paradigm in Neuroblastoma / / written by Giorgia Centonze [and eight others].

Neuroblastoma, the most common extra-cranial pediatric solid tumor, is responsible for 9-15% of all pediatric cancer deaths. Its intrinsic heterogeneity makes it difficult to successfully treat, resulting in overall survival of 50% for half of the patients. Here we analyze the role in neuroblastoma...

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Bibliographic Details
VerfasserIn:
Centonze, Giorgia,
Place / Publishing House:London : : IntechOpen,, 2021.
Year of Publication:2021
Language:English
Physical Description:1 online resource (130 pages)
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Table of Contents:
  • 1. Introduction
  • 2. The p140Cap adaptor protein
  • 3. SRCIN1 mRNA expression is an independent prognostic marker for NB
  • 4. p140Cap negatively affects tumorigenic features
  • 5. Molecular mechanisms and therapeutic targets in neuroblastoma
  • 6. p140Cap impairs the Src/p130Cas and the STAT3/Jak2 signaling pathways
  • 7. p140Cap increases NB cell sensitivity to chemotherapeutic treatment
  • 8. p140Cap increases NB cell sensitivity to Src kinase inhibitors
  • 9. Conclusions
  • Acknowledgments
  • Conflict of interest
  • Rights and permissions
  • Abbreviations
  • References.

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