Molecular-Level Understanding of the Anticancer Action Mechanism of Anthracyclines /

Molecular-Level Understanding of the Anticancer Action Mechanism of Anthracyclines / / written by Manish Shandilya [and three others].

Anthracyclines drugs are used as a treatment regime to combat cancer owing to their great chemotherapeutic potential. They are characterized by the presence of a wide range of derivatives, the most famous are doxorubicin and daunorubicin. The proposed action mechanism of anthracyclines and their der...

Full description

Saved in:
Bibliographic Details
VerfasserIn:
Shandilya, Manish,
Place / Publishing House:London : : IntechOpen,, 2020.
Year of Publication:2020
Language:English
Physical Description:1 online resource (260 pages)
Tags: Add Tag
No Tags, Be the first to tag this record!
Table of Contents:
  • 1. Introduction
  • 2. Proposed action mechanisms
  • 2.1 Anthracyclines as DNA intercalators
  • 2.2 How anthracyclines damage DNA?
  • 2.2.1 Via topoisomerase II poisoning
  • 2.2.2 Via oxidative stress
  • 2.2.3 Via forming DNA-anthracycline adduct
  • 3. Side effects
  • 4. Anthracycline resistance
  • 5. Anthracycline analogs
  • 6. Conclusion
  • Acknowledgments
  • Conflict of interest
  • References.

Similar Items