Pressure Perturbation Approach in Biochemistry and Structural Biology : : In memoriam of Dr. Gaston Hui Bon Hoa / / Dmitri Davydov, Christiane Jung.

• VerfasserIn: Davydov, Dmitri,; Jung, Christiane,
• TeilnehmendeR: Jung, Christiane,
• Place / Publishing House: Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, 2022.
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (160 pages)

This Special Issue focuses on the effects of hydrostatic pressure on biological systems and the use of these effects for exploring the structure, function, and molecular dynamics of biological macromolecules and their ensembles. Here, we present a selection of papers highlighting new experimental findings and new theoretical concepts in high-pressure biosciences. In these studies, the authors combine pressure perturbation approaches with NMR and optical spectroscopy, kinetic and thermodynamic techniques, functional genomics and transcriptomics, and molecular dynamics simulations to gain new insights into the conformational dynamics of proteins and nucleic acids and to better understand the mechanisms of high-pressure adaptation in piezophiles. The articles collected in this issue demonstrate the unique exploratory potential of the pressure perturbation approach for biochemistry, biophysics, mechanistic enzymology, and evolutionary biology.

Table of Contents

About the Editors -- Preface to "Pressure Perturbation Approach in Biochemistry and Structural Biology. In -- memoriam of Dr. Gaston Hui Bon Hoa" -- A Pathfinder in High-Pressure Bioscience: In Memoriam of Gaston Hui Bon Hoa -- Proteins in Wonderland: The Magical World of Pressure -- Comparative Assessment of NMR Probes for the Experimental Description of Protein Folding Pathways with High-Pressure NMR -- Conformational Rearrangements in the Redox Cycling of NADPH-Cytochrome P450 Reductase from Sorghum bicolor Explored with FRET and Pressure-Perturbation Spectroscopy -- Pressure Adaptations in Deep-Sea Moritella Dihydrofolate Reductases: Compressibility versus Stability -- The Effects of Temperature and Pressure on Protein-Ligand Binding in the Presence of Mars-Relevant Salts -- Kinetic Study of the Avocado Sunblotch Viroid Self-Cleavage Reaction Reveals Compensatory -- Effects between High-Pressure and High-Temperature: Implications for Origins of Life on Earth -- Pressure Perturbation Studies of Noncanonical Viral Nucleic Acid Structures -- Volumetric Properties of Four-Stranded DNA Structures -- Fumiyoshi Abe Molecular Responses to High Hydrostatic Pressure in Eukaryotes: Genetic Insights from Studies on Saccharomyces cerevisiae.