Viruses and Nuclear Egress / / edited by Donald M. Coen.

• TeilnehmendeR: Coen, Donald M.,
• Place / Publishing House: Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, 2022.
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (182 pages)

This Special Issue of Viruses focuses on the topic of viruses and nuclear egress. Nuclear egress is a fascinating process by which herpesvirus nucleocapsids make their way from the nuclear interior to the cytoplasm. As nuclear egress and the viral proteins that orchestrate it differ from host processes and proteins in important ways, there is interest in targeting antiviral therapies to disrupt this process. Indeed, the recently approved drug maribavir acts in large part by inhibiting a step of nuclear egress. The Special Issue includes five reviews-three on nuclear egress of two alphaherpesviruses, herpes simplex virus and pseudorabies virus; one on a betaherpevirus, human cytomegalovirus; and one on a gammaherpesvirus, Epstein-Barr virus-and five research papers-two on alphaherpesviruses and three on human cytomegalovirus.

Table of Contents

Host and Viral Factors Involved in Nuclear Egress of Herpes Simplex Virus 1 -- When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding -- Erratum: Rose et al. When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding. Viruses 2021, 13, 1138 -- Herpesvirus Nuclear Egress across the Outer Nuclear Membrane -- Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions -- Conquering the Nuclear Envelope Barriers by EBV Lytic Replication -- Role of Vesicle-Associated Membrane Protein-Associated Proteins (VAP) A and VAPB in Nuclear Egress of the Alphaherpesvirus Pseudorabies Virus -- The HSV1 Tail-Anchored Membrane Protein pUL34 Contains a Basic Motif That Supports Active Transport to the Inner Nuclear Membrane Prior to Formation of the Nuclear Egress Complex -- Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation -- Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery -- Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection.