Staff View: Brain-Targeted Drug Delivery

Brain-Targeted Drug Delivery

Brain diseases currently affect one in six people worldwide; they include a wide range of neurological diseases, from Alzheimer’s and Parkinson’s diseases to epilepsy, brain injuries, brain cancer, neuroinfections, and strokes. The treatment of these diseases is complex and limited due to the presen...

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Sonstige:	Sousa, Flávia
Year of Publication:	2022
Language:	English
Physical Description:	1 electronic resource (260 p.)
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spelling	Sousa, Flávia edt Brain-Targeted Drug Delivery MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (260 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Open access Unrestricted online access star Brain diseases currently affect one in six people worldwide; they include a wide range of neurological diseases, from Alzheimer’s and Parkinson’s diseases to epilepsy, brain injuries, brain cancer, neuroinfections, and strokes. The treatment of these diseases is complex and limited due to the presence of the blood–brain barrier (BBB), which covers the entirety of the brain. The BBB not only has the function of protecting the brain from harmful substances; it is also a metabolic barrier and a transport regulator of nutrients/serum factors/neurotoxins. Knowing these characteristics when it comes to the treatment of brain diseases makes it easier to understand the lack of efficacy of therapeutic drugs, resulting from the innate resistance of the BBB to permeation. To overcome this limitation, drug delivery systems based on nanotechnology/microtechnology have been developed. Brain-targeted drug delivery enables targeted therapy with a higher therapeutic efficacy and fewer side effects because it targets moieties present in the drug delivery systems. English Technology: general issues bicssc drug delivery into the brain transendothelium based on receptor-mediated transcytosis immunotherapy Alzheimer's disease anti-tau and anti-receptor bispecific monoclonal antibodies Alzheimer's disease-relevant tau species temporal-spatial pathological Aβ and tau distribution interactions between Aβ and tau tau clearance in microglia tau clearance in neurons liposome nanoparticle seizure laser ultrasound naringenin nanostructured lipid carrier intranasal delivery central composite rotatable design depression pomegranate seed oil nasal delivery system memory impairment movement impairment delivery to brain improved memory phospholipid oily gel high-grade glioma diffuse midline glioma glioblastoma IL-13Rα2 IL-13 immunotoxin targeted therapy GB-13 IL13.E13K-PE4E receptor expression acetaminophen blood-brain barrier claudin-5 CNS drug delivery opioids tight junction microdialysis cerebral open flow microperfusion electrochemical biosensors macromolecules tolcapone microparticles nanoparticles PLGA Parkinson's disease nose to brain delivery gene therapy polyplexes hyaluronidase glycol chitosan brain cancer chemoattractant CXCL CXCR glioblastoma multiforme 3D cell culture systems non-human primate convection-enhanced delivery neurosurgery optogenetics brain targeted therapy drug delivery cerebrospinal fluid microcirculation brain biodistribution 3-0365-5282-0 Sousa, Flávia oth
language	English
format	eBook
author2	Sousa, Flávia
author_facet	Sousa, Flávia
author2_variant	f s fs
author2_role	Sonstige
title	Brain-Targeted Drug Delivery
spellingShingle	Brain-Targeted Drug Delivery
title_full	Brain-Targeted Drug Delivery
title_fullStr	Brain-Targeted Drug Delivery
title_full_unstemmed	Brain-Targeted Drug Delivery
title_auth	Brain-Targeted Drug Delivery
title_new	Brain-Targeted Drug Delivery
title_sort	brain-targeted drug delivery
publisher	MDPI - Multidisciplinary Digital Publishing Institute
publishDate	2022
physical	1 electronic resource (260 p.)
isbn	3-0365-5281-2 3-0365-5282-0
illustrated	Not Illustrated
work_keys_str_mv	AT sousaflavia braintargeteddrugdelivery
status_str	n
ids_txt_mv	(CKB)5670000000391602 (oapen)https://directory.doabooks.org/handle/20.500.12854/93194 (EXLCZ)995670000000391602
carrierType_str_mv	cr
is_hierarchy_title	Brain-Targeted Drug Delivery
author2_original_writing_str_mv	noLinkedField
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Brain-Targeted Drug Delivery

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