Arthropod Venom Components and Their Potential Usage / / Gandhi Rádis-Baptista, Katsuhiro Konno.

• VerfasserIn: Rádis-Baptista, Gandhi,; Konno, Katsuhiro,
• TeilnehmendeR: Konno, Katsuhiro,
• Place / Publishing House: Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, 2020.
• Year of Publication: 2020
• Language: English
• Physical Description: 1 online resource (404 pages)

Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods' venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC-MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.

Table of Contents

About the Special Issue Editors -- Gandhi R ´adis-Baptista and Katsuhiro Konno Arthropod Venom Components and Their Potential Usage Reprinted from: Toxins 2020 -- Justin O. Schmidt Pain and Lethality Induced by Insect Stings: An Exploratory and Correlational Study Reprinted from: Toxins 2019 -- Jimena I. Cid-Uribe, Erika P. Meneses, Cesar V. F. Batista, Ernesto Ortiz and Lourival D. Possani Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous Scorpion Centruroides limpidus (Karsch, 1879) Reprinted from: Toxins 2019 -- Douglas Oscar Ceolin Mariano, Ursula Castro de Oliveira, Andre Junqueira Zaharenko, Daniel Carvalho Pimenta, Gandhi Radis-Baptista and Alvaro Rossan de Brandao Prieto-da-Silva Bottom-Up Proteomic Analysis of Polypeptide Venom Components of the Giant Ant Dinoponera Quadriceps Reprinted from: Toxins 2019 -- Naoki Tani, Kohei Kazuma, Yukio Ohtsuka, Yasushi Shigeri, Keiichi Masuko, Katsuhiro Konno and Hidetoshi Inagaki Mass Spectrometry Analysis and Biological Characterization of the Predatory Ant Odontomachus monticola Venom and Venom Sac Components Reprinted from: Toxins 2019 -- Rogerio Coutinho das Neves, M´arcia Renata Mortari, Elisabeth Ferroni Schwartz, Andre Kipnis and Ana Paula Junqueira-Kipnis Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii Reprinted from: Toxins 2019 -- Marcia Perez dos Santos Cabrera, Marisa Rangel, Jo˜ao Ruggiero Neto and Katsuhiro Konno Chemical and Biological Characteristics of Antimicrobial α-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes Reprinted from: Toxins 2019 -- Carolina Nunes da Silva, Flavia Rodrigues da Silva, Lays Fernanda Nunes Dourado, PabloVictor Mendes dos Reis, Rummenigge Oliveira Silva, Bruna Lopes da Costa, Paula Santos Nunes, Flavio Almeida Amaral, Vera Lucia dos Santos, Maria Elena de Lima and Armando da Silva Cunha Junior A New Topical Eye Drop Containing LyeTxI-b, A Synthetic Peptide Designed from A Lycosa erithrognata Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis Reprinted from: Toxins 2019 -- Elias Ferreira Sabia Junior, Luis Felipe Santos Menezes, Israel Flor Silva de Araujo and Elisabeth Ferroni Schwartz Natural Occurrence in Venomous Arthropods of Antimicrobial Peptides Active against Protozoan Parasites Reprinted from: Toxins 2019 -- Danielle Bruno de Carvalho, Eduardo Gon¸calves Paterson Fox, Diogo Gama dos Santos, Joab Sampaio de Sousa, Denise Maria Guimaraes Freire, Fabio C. S. Nogueira, Gilberto B. Domont, Livia Vieira Araujo de Castilho and Ednildo de Alcantara Machado Fire Ant Venom Alkaloids Inhibit Biofilm Formation Reprinted from: Toxins 2019, -- Douglas W. Whitman, Maria Fe Andres, Rafael A. Martinez-Diaz, Alexandra Ibanez-Escribano, A. Sonia Olmeda and Azucena Gonzalez-Coloma Antiparasitic Properties of Cantharidin and the Blister Beetle Berberomeloe majalis (Coleoptera: Meloidae) Reprinted from: Toxins 2019 -- Haejoong Kim, Soo-Yeon Park and Gihyun Lee Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review Reprinted from: Toxins 2019 -- Jan Lubawy, Arkadiusz Urbanski, Lucyna Mrowczynska, Eliza Matuszewska, Agata Swiatły-Błaszkiewicz, Jan Matysiak and Grzegorz Rosinski The Influence of Bee Venom Melittin on the Functioning of the Immune System and the Contractile Activity of the Insect Heart-A Preliminary Study Reprinted from: Toxins 2019 -- Seunghwan Choi, Hyeon Kyeong Chae, Ho Heo, Dae-Hyun Hahm, Woojin Kim and Sun Kwang Kim Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats Reprinted from: Toxins 2019 -- Craig A. Doupnik Identification of Aethina tumida Kir Channels as Putative Targets of the Bee Venom Peptide Tertiapin Using Structure-Based Virtual Screening Methods Reprinted from: Toxins 2019 -- Yashad Dongol, Fernanda Caldas Cardoso and Richard J Lewis Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways -- Reprinted from: Toxins -- Daniele Chaves-Moreira, Fernando Hitomi Matsubara, Zelinda Schemczssen-Graeff, Elidiana De Bona, Vanessa Ribeiro Heidemann, Clara Guerra-Duarte, Luiza Helena Gremski, Carlos Chavez-Olortegui, Andrea Senff-Ribeiro, Olga Meiri Chaim, Raghuvir Krishnaswamy Arni and Silvio Sanches Veiga Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics Reprinted from: Toxins 2019 -- Sebastien Nicolas, Claude Zoukimian, Frank Bosmans, Jerome Montnach, Sylvie Diochot, Eva Cuypers, Stephan De Waard, Remy Beroud, Dietrich Mebs, David Craik, Didier Boturyn, Michel Lazdunski, Jan Tytgat and Michel De Waard Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1 Reprinted from: Toxins 2019 -- Carmen Hernandez, Katsuhiro Konno, Emilio Salceda, Rosario Vega, Andre Junqueira Zaharenko and Enrique Soto Sa12b Peptide from Solitary Wasp Inhibits ASIC Currents in Rat Dorsal Root Ganglion Neurons Reprinted from: Toxins 2019 -- Paula A. L. Calabria, Lhiri Hanna A. L. Shimokava-Falcao, Monica Colombini, Ana M. Moura-da-Silva, Katia C. Barbaro, Eliana L. Faquim-Mauro and Geraldo S. Magalhaes Design and Production of a Recombinant Hybrid Toxin to Raise Protective Antibodies againstLoxosceles Spider Venom Reprinted from: Toxins 20199 -- Yusuke Yoshimoto, Masahiro Miyashita, Mohammed Abdel-Wahab, Moustafa Sarhan, Yoshiaki Nakagawa and Hisashi Miyagawa Isolation and Characterization of Insecticidal Toxins from the Venom of the North African Scorpion, Buthacus leptochelys Reprinted from: Toxins 2019.