MicroRNA in Solid Tumor and Hematological Diseases / / Francesca Lovat.

• VerfasserIn: Lovat, Francesca,
• Place / Publishing House: Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, 2022.
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (226 pages)

MicroRNAs (miRNAs), which are a type of short non-coding RNA, are involved in number of processes, such as differentiation, development, inflammation, immune response, and cancer. miRNAs, which act as oncogenes or tumor suppressor genes, can control and regulate the translation and stability of target messenger RNA, contributing to cancer pathogenesis. Despite the progress that has been made in discovering the mechanisms of how miRNAs function in tumors, many questions and aspects of miRNA biology and processing still remain to be determined. This Special Issue, titled "MicroRNA in Solid Tumor and Hematological Diseases", provides a panorama of the existing knowledge gaps and potential uses of microRNAs to predict clinical outcome or response to therapies and provides evidence to explain their role as biomarkers to modulate the biological pathways that are critical for cancer development and progression. It includes eleven peer-reviewed papers that cover the role of microRNAs in different tumor types and their potential applications in diagnosis and clinical approaches.

Table of Contents

Editorial to the Special Issue "MicroRNA in Solid Tumor and Hematological Diseases" -- Serum miRNA Profiling for Early PDAC Diagnosis and Prognosis: A Retrospective Study -- Profiling 25 Bone Marrow microRNAs in Acute Leukemias and Secondary Nonleukemic Hematopoietic Conditions -- Regulation of Oncogenic Targets by the Tumor-Suppressive miR-139 Duplex (miR-139-5p and miR-139-3p) in Renal Cell Carcinoma -- Identification of miR-29c-3p as a Robust Normalizer for Urine microRNA Studies in Bladder Cancer -- MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer -- Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms -- The Multifaceted Role and Utility of MicroRNAs in Indolent B-Cell Non-Hodgkin Lymphomas -- MiR-7 in Cancer Development -- MicroRNAs as Predictive Biomarkers of Resistance to Targeted Therapies in Gastrointestinal Tumors -- LAT1 and ASCT2 Related microRNAs as Potential New Therapeutic Agents against Colorectal Cancer Progression -- Role of Circulating miRNAs in Therapeutic Response in Epithelial Ovarian Cancer: A Systematic Revision.