Colorectal Cancer : : From Pathophysiology to Novel Therapeutic Approaches / / Valeria Barresi.

• VerfasserIn: Barresi, Valeria,
• Place / Publishing House: Basel, Switzerland : : MDPI - Multidisciplinary Digital Publishing Institute,, 2022.
• Year of Publication: 2022
• Language: English
• Physical Description: 1 Online-Ressource (284 pages)

Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions.

Table of Contents

About the Editor vii -- Valeria Barresi, Colorectal Cancer: From Pathophysiology to Novel Therapeutic Approaches Reprinted from: Biomedicines 2021, 9, 1858, doi:10.3390/biomedicines9121858 1 -- Marco Vacante, Roberto Ciuni, Francesco Basile and Antonio Biondi, Gut Microbiota and Colorectal Cancer Development: A Closer Look to the Adenoma-Carcinoma Sequence Reprinted from: Biomedicines 2020, 8, 489, doi:10.3390/biomedicines8110489 5 -- Jan Philipp Dobert, Anne-Sophie Cabron, Philipp Arnold, Egor Pavlenko, Stefan Rose-John and Friederike Zunke, Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain Reprinted from: Biomedicines 2020, 8, 463, doi:10.3390/biomedicines8110463 27 -- Marco Vacante, Roberto Ciuni, Francesco Basile and Antonio Biondi, The Liquid Biopsy in the Management of Colorectal Cancer: An Overview Reprinted from: Biomedicines 2020, 8, 308, doi:10.3390/biomedicines8090308 43 -- Alessandro Parisi, Giampiero Porzio, Fanny Pulcini, Katia Cannita, Corrado Ficorella, Vincenzo Mattei and Simona Delle Monache, What Is Known about Theragnostic Strategies in Colorectal Cancer Reprinted from: Biomedicines 2021, 9, 140, doi:biomedicines9020140 65 -- Giulia Turri, Valeria Barresi, Alessandro Valdegamberi, Gabriele Gecchele, Cristian Conti, Serena Ammendola, Alfredo Guglielmi, Aldo Scarpa and Corrado Pedrazzani, Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters Reprinted from: Biomedicines 2021, 9, 94, doi:biomedicines9010094 95 -- Kyusang Hwang, Jin Hwan Yoon, Ji Hyun Lee and Sukmook Lee, Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers Reprinted from: Biomedicines 2021, 9, 39, doi:biomedicines9010039 107 -- Ugo Testa, Germana Castelli and Elvira Pelosi, Genetic Alterations of Metastatic Colorectal Cancer Reprinted from: Biomedicines 2020, 8, 414, doi:10.3390/biomedicines8100414 131 -- Kristian Urh, Margareta Zlajpah, Nina Zidar and Emanuela Boˇ ˇ stjanˇciˇc, Identification and Validation of New Cancer Stem Cell-Related Genes and Their Regulatory microRNAs in Colorectal Cancerogenesis Reprinted from: Biomedicines 2021, 9, 179, doi:10.3390/biomedicines9020179 161 -- Flaviana Marzano, Mariano Francesco Caratozzolo, Graziano Pesole, Elisabetta Sbis `a and Apollonia Tullo, TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance Reprinted from: Biomedicines 2021, 9, 241, doi:10.3390/biomedicines9030241 181 -- Jachym Rosendorf, Marketa Klicova, Lenka Cervenkova, Jana Horakova, Andrea Klapstova, Petr Hosek, Richard Palek, Jan Sevcik, Robert Polak, Vladislav Treska, Jiri Chvojka and Vaclav Liska, Reinforcement of Colonic Anastomosis with Improved Ultrafine Nanofibrous Patch: Experiment on Pig Reprinted from: Biomedicines 2021, 9, 102, doi:10.3390/biomedicines9020102 203 -- Raffaella Liccardo, Antonio Nolano, Matilde Lambiase, Carlo Della Ragione, Marina De Rosa, Paola Izzo and Francesca Duraturo, MSH2 Overexpression Due to an Unclassified Variant in 3 -Untranslated Region in a Patient with Colon Cancer Reprinted from: Biomedicines 2020, 8, 167, doi:10.3390/biomedicines8060167 221 -- Helle Samdal, Lene C Olsen, Knut S Grøn, Elin S Røyset, Therese S Høiem, Ingunn Nervik, P ˚al Sætrom, Arne Wibe, Svanhild A Schønberg and Caroline H H Pettersen, Establishment of a Patient-Derived Xenograft Model of Colorectal Cancer in CIEA NOG Mice and Exploring Smartfish Liquid Diet as a Source of Omega-3 Fatty Acids Reprinted from: Biomedicines 2021, 9, 282, doi:10.3390/biomedicines9030282 231 -- Carolina Peixoto, Marta B. Lopes, Marta Martins, Lu´ıs Costa and Susana Vinga, TCox: Correlation-Based Regularization Applied to Colorectal Cancer Survival Data Reprinted from: Biomedicines 2020, 8, 488, doi:10.3390/biomedicines8110488 259.