Multiple Sclerosis : : Diagnosis and Treatment II / / Víctor M. Rivera.

• VerfasserIn: Rivera, Víctor M.,
• Place / Publishing House: Basel, Switzerland : : MDPI - Multidisciplinary Digital Publishing Institute,, 2022.
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (160 pages)

The book "Multiple Sclerosis: Diagnosis and Treatment" provides a collection of selected articles published in Biomedicines as part of Volume II addressing current issues on this major inflammatory demyelinating neurological disorder. The articles describe recent advances and discoveries in the molecular and cell microenvironment contributing to neuro-inflammation in the brain and spinal cord. The role of the neurofilaments light chain as a serological biomarker of axonal and neuronal degeneration of the CNS is presented not just as a sensitive diagnostic tool, but also as an indicator of treatment responses. The new generation of therapeutic molecules belonging to the sphingosine-1-phosphate class are discussed, and their potential as disease-modifying treatment is considered. Investigations into the intimate molecular mechanisms of highly active MS, disclosed clinically and by MRI, are discussed by researchers proposing that the expression of RNAs in peripheral blood cells is a biomarker of highly active disease. The book also addresses important clinical and epidemiological aspects of pediatric MS and that in multi-ethnic cohorts.

Table of Contents

About the Editor ii -- Victor M. Rivera Editorial of Special Issue "Multiple Sclerosis: Diagnosis and Treatment II" Reprinted from: Biomedicines 2021, 9, 1605, doi:10.3390/biomedicines9111605 1 -- Valentina Gatta, Guadalupe Mengod, Marcella Reale and Ada Maria Tata Possible Correlation between Cholinergic System Alterations and Neuro/Inflammation in Multiple Sclerosis Reprinted from: Biomedicines 2020, 8, 153, doi:10.3390/biomedicines8060153 7 -- Domenico De Rasmo, Anna Ferretta, Silvia Russo, Maddalena Ruggieri, Piergiorgio Lasorella, Damiano Paolicelli, Maria Trojano and Anna Signorile PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels Reprinted from: Biomedicines 2020, 8, 85, doi:10.3390/biomedicines8040085 23 -- Vicki Mercado, Deepa Dongarwar, Kristen Fisher, Hamisu M. Salihu, George J. Hutton and Fernando X. Cuascut Multiple Sclerosis in a Multi-Ethnic Population in Houston, Texas: A Retrospective Analysis Reprinted from: Biomedicines 2020, 8, 534, doi:10.3390/biomedicines8120534 35 -- Simon Thebault, Ronald A. Booth and Mark S. Freedman Blood Neurofilament Light Chain: The Neurologist's Troponin? Reprinted from: Biomedicines 2020, 8, 523, doi:10.3390/biomedicines8110523 47 -- Mariano Marrodan, Mar´ıa I. Gait´an and Jorge Correale Spinal Cord Involvement in MS and Other Demyelinating Diseases Reprinted from: Biomedicines 2020, 8, 130, doi:10.3390/biomedicines8050130 59 -- Stanley Cohan, Elisabeth Lucassen, Kyle Smoot, Justine Brink and Chiayi Chen Sphingosine-1-Phosphate: Its Pharmacological Regulation and the Treatment of Multiple Sclerosis: A Review Article Reprinted from: Biomedicines 2020, 8, 227, doi:10.3390/biomedicines8070227 85 -- Andr´e Huss, Makbule Senel, Ahmed Abdelhak, Benjamin Mayer, Jan Kassubek, Albert C. Ludolph, Markus Otto and Hayrettin Tumani Longitudinal Serum Neurofilament Levels of Multiple Sclerosis Patients Before and After Treatment with First-Line Immunomodulatory Therapies Reprinted from: Biomedicines 2020, 8, 312, doi:10.3390/biomedicines8090312 109 -- Leire Iparraguirre, Danel Olaverri, Telmo Blasco, Luc´ıa Sep´ulveda, Tamara Castillo-Trivi˜no, Mercedes Espi˜no, Lucienne Costa-Frossard, ´Alvaro Prada, Luisa Mar´ıa Villar, David Otaegui and Maider Mu˜noz-Culla Whole-Transcriptome Analysis in Peripheral Blood Mononuclear Cells from Patients with Lipid-Specific Oligoclonal IgM Band Characterization Reveals Two Circular RNAs and Two Linear RNAs as Biomarkers of Highly Active Disease Reprinted from: Biomedicines 2020, 8, 540, doi:10.3390/biomedicines8120540 121 -- Kristen S. Fisher, Fernando X. Cuascut, Victor M. Rivera and George J. Hutton Current Advances in Pediatric Onset Multiple Sclerosis Reprinted from: Biomedicines 2020, 8, 71, doi:10.3390/biomedicines8040071 137.