Arteriogenesis and therapeutic angiogenesis / / Paul Quax, Elisabeth Deindl.

• VerfasserIn: Quax, Paul,; Deindl, Elisabeth,
• TeilnehmendeR: Deindl, Elisabeth,
• Place / Publishing House: Basel : : MDPI - Multidisciplinary Digital Publishing Institute,, [2022]; ©2022
• Year of Publication: 2022
• Language: English
• Physical Description: 1 online resource (230 pages)

Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.

Table of Contents

About the Editors -- Arteriogenesis and Therapeutic Angiogenesis-An Update -- The Role of Circulating Biomarkers in Peripheral Arterial Disease -- Clinical Application of Novel Therapies for Coronary Angiogenesis: Overview, Challenges, and Prospects -- Current Status of Angiogenic Cell Therapy and Related Strategies Applied in Critical Limb Ischemia -- Role of Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis -- In Vivo Matrigel Plug Assay as a Potent Method to Investigate Specific Individual Contribution of Angiogenesis to Blood Flow Recovery in Mice -- Impact of C57BL/6J and SV-129 Mouse Strain Differences on Ischemia-Induced Postnatal Angiogenesis and the Associated Leukocyte Infiltration in a Murine Hindlimb Model of Ischemia -- The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia -- Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p -- Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development -- BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice -- Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors -- Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy.