Mass Spectrometry Application in Biology / / MDPI AG - Multidisciplinary Digital Publishing Institute.

• VerfasserIn: MDPI AG - Multidisciplinary Digital Publishing Institute,
• Place / Publishing House: [Place of publication not identified] : : MDPI - Multidisciplinary Digital Publishing Institute,, 2014.
• Year of Publication: 2014
• Language: English
• Physical Description: 1 online resource (252 pages)

Mass spectrometry (MS) has become a vital tool for scientist in exploring how biological systems function and how therapeutic drug intervention (both small molecules and biologics) impact these systems. The application of mass spectrometry has advanced our knowledge in the biological sciences through the study of proteins and peptides in proteomics and as biomarkers, imaging via MALDI MS, and analysis of SNP's in the genome to allow personalized medical treatment. The aim of this book is to provide a glimpse of some of the many applications of the advancing field of mass spectrometry and its application to complex biological problems. The topics presented here touch on many of the areas listed above will hopefully serve as a catalyst to generate new ideas for the continued innovative application of mass spectrometry to the fields of medicine, biology and beyond.

Table of Contents

List of Contributors -- Preface -- Phosphorylation Stoichiometries of Human Eukaryotic Initiation Factors -- Direct Analysis of hCGßcf Glycosylation in Normal and Aberrant Pregnancy by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry -- Quantitative Proteomics to Characterize Specific Histone H2A Proteolysis in Chronic Lymphocytic Leukemia and the Myeloid THP-1 Cell Line -- Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients -- Radiosensitization of Human Leukemic HL-60 Cells by ATR Kinase Inhibitor (VE-821): Phosphoproteomic Analysis -- Development of Laser Ionization Techniques for Evaluation of the Effect of Cancer Drugs Using Imaging Mass Spectrometry -- Continuous Flow Atmospheric Pressure Laser Desorption/Ionization Using a 6-7-µm-Band Mid-Infrared Tunable Laser for Biomolecular Mass Spectrometry -- Access of Hydrogen-Radicals to the Peptide-Backbone as a Measure for Estimating the Flexibility of Proteins Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry -- Legionella dumoffii Utilizes Exogenous Choline for Phosphatidylcholine Synthesis -- Recent Advances in Bacteria Identification by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Using Nanomaterials as Affinity Probes -- MALDI Q-TOF CID MS for Diagnostic Ion Screening of Human Milk Oligosaccharide Samples -- Interleukin-6 Receptor rs7529229 T/C Polymorphism Is Associated with Left Main Coronary Artery Disease Phenotype in a Chinese Population -- Investigation into Variation of Endogenous Metabolites in Bone Marrow Cells and Plasma in C3H/He Mice Exposed to Benzene -- Phosphosite Mapping of HIP-55 Protein in Mammalian Cells -- Mass Spectrometry Analysis Coupled with de novo Sequencing Reveals Amino Acid Substitutions in Nucleocapsid Protein from Influenza A Virus.