Tumour Viruses / / edited by Joanna Parish.

• TeilnehmendeR: Parish, Joanna,
• Place / Publishing House: Basel : : MDPI,, 2016.
• Year of Publication: 2016
• Language: English
• Physical Description: 1 online resource (470 pages)

Current worldwide estimates suggest that approxiamtely 11% of all cancers are caused by viral infections. At present, there are eight viruses that have a strong association with cancer development namely, human papillomavirus, Epstein-Barr virus, Kaposi's sarcoma-associated herpes virus, human T-cell lymphotrophic virus type I, Merkel cell polyomavirus, hepatitis B and C viruses and human immunodeficiency virus. Some of these viruses and associated cancers, such as human papillomavirus and cervical cancer, are well studied and the causal link between infection and cancer development is established. However, the involvement of these known oncogenic viruses in cancer development at other body sites is not well understood and further study of these viruses continues to highlight novel mechanisms of cellular transformation. Other cancer-associated viruses are only recently discovered, such as Merkel cell polyomavirus, and further work is required to formally prove their role in cancer development. In this Special Issue, we seek to explore novel mechanisms of cellular transformation by oncogenic viruses, the role of viral infection in cancer development in understudied body sites and the potential role of novel viral pathogens in cancer development.

Table of Contents

Table of Contents List of Contributors. VII. About the Guest Editor. XII.Preface. XIII. Abigail Morales-Sánchez and Ezequiel M. Fuentes-Pananá Human Viruses and Cancer Reprinted from: Viruses 2014, 6(10), 4047-4079http://www.mdpi.com/1999-4915/6/10/4047 .1. Ugo Moens, Kashif Rasheed, Ibrahim Abdulsalam and Baldur Sveinbjørnsson The Role of Merkel Cell Polyomavirus and Other Human Polyomaviruses in Emerging Hallmarks of Cancer Reprinted from: Viruses 2015, 7(4), 1871-1901 http://www.mdpi.com/1999-4915/7/4/1871. 34. Nagayasu Egawa, Kiyofumi Egawa, Heather Griffin and John Doorbar Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia Reprinted from: Viruses 2015, 7(7), 3863-3890 http://www.mdpi.com/1999-4915/7/7/2802. 66. Torbjörn Ramqvist, Nathalie Grün and Tina Dalianis Human Papillomavirus and Tonsillar and Base of Tongue Cancer Reprinted from: Viruses 2015, 7(3), 1332-1343 http://www.mdpi.com/1999-4915/7/3/1332. 95. Georgia Schäfer, Melissa J. Blumenthal and Arieh A. Katz Interaction of Human Tumor Viruses with Host Cell Surface Receptors and Cell Entry Reprinted from: Viruses 2015, 7(5), 2592-2617 http://www.mdpi.com/1999-4915/7/5/2592. 108. Jennifer Biryukov and Craig Meyers Papillomavirus Infectious Pathways: A Comparison of Systems Reprinted from: Viruses 2015, 7(8), 4303 4325 http://www.mdpi.com/1999-4915/7/8/2823 .134. IV Bart Tummers and Sjoerd H. van der Burg High-Risk Human Papillomavirus Targets Crossroads in Immune Signaling Reprinted from: Viruses 2015, 7(5), 2485-2506 http://www.mdpi.com/1999-4915/7/5/2485. 158. Robert Hollingworth and Roger J. Grand Modulation of DNA Damage and Repair Pathways by Human Tumour Viruses Reprinted from: Viruses 2015, 7(5), 2542 2591 http://www.mdpi.com/1999-4915/7/5/2542. 179. Caleb C. McKinney, Katherine L. Hussmann and Alison A. McBride The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle Reprinted from: Viruses 2015, 7(5), 2450-2469 http://www.mdpi.com/1999-4915/7/5/2450. 228.Robert Hollingworth, George L. Skalka, Grant S. Stewart, Andrew D. Hislop, David J. Blackbourn and Roger J. Grand Activation of DNA Damage Response Pathways during Lytic Replication of KSHV Reprinted from: Viruses 2015, 7(6), 2908-2927 http://www.mdpi.com/1999-4915/7/6/2752. 249.Ieisha Pentland and Joanna L. Parish Targeting CTCF to Control Virus Gene Expression: A Common Theme amongst Diverse DNA VirusesReprinted from: Viruses 2015, 7(7), 3574-3585 http://www.mdpi.com/1999-4915/7/7/2791. 270. Jesus Omar Muñoz Bello, Leslie Olmedo Nieva, Adriana Contreras Paredes, Alma Mariana Fuentes Gonzalez, Leticia Rocha Zavaleta and Marcela Lizano Regulation of the Wnt/ȕ-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins Reprinted from: Viruses 2015, 7(8), 4734-4755 http://www.mdpi.com/1999-4915/7/8/2842. 282. V Ketaki Ganti, Justyna Broniarczyk, Wiem Manoubi, Paola Massimi, Suruchi Mittal, David Pim, Anita Szalmas, Jayashree Thatte, Miranda Thomas, Vjekoslav Tomaiü and Lawrence Banks The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy Reprinted from: Viruses 2015, 7(7), 3530-3551 http://www.mdpi.com/1999-4915/7/7/2785. 304. Peng Sun, Li Dong, Alasdair I. MacDonald, Shahrzad Akbari, Michael Edward, Malcolm B. Hodgins, Scott R. Johnstone and Sheila V. Graham HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells Reprinted from: Viruses 2015, 7(10), 5243-5256 http://www.mdpi.com/1999-4915/7/10/2871. 327. Sonia N. Whang, Maria Filippova and Penelope Duerksen-Hughes Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer Reprinted from: Viruses 2015, 7(9), 5040-5065 http://www.mdpi.com/1999-4915/7/9/2860. 344. Özlem Cesur, Clare Nicol, Helen Groves, Jamel Mankouri, George Eric Blair and Nicola J. Stonehouse The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers Reprinted from: Viruses 2015, 7(7), 3443-3461 http://www.mdpi.com/1999-4915/7/7/2780. 377. Tamar Kleinberger Mechanisms of Cancer Cell Killing by the Adenovirus E4orf4 Protein Reprinted from: Viruses 2015, 7(5), 2334-2357 http://www.mdpi.com/1999-4915/7/5/2334. 396. Elizabeth I. Vink, Yueting Zheng, Rukhsana Yeasmin, Thomas Stamminger, Laurie T. Krug and Patrick Hearing Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression Reprinted from: Viruses 2015, 7(5), 2428-2449 http://www.mdpi.com/1999-4915/7/5/2428. 421. VI Zhiqiang Qin, Francesca Peruzzi, Krzysztof Reiss and Lu Dai Role of Host MicroRNAs in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis Reprinted from: Viruses 2014, 6(11), 4571-4580 http://www.mdpi.com/1999-4915/6/11/4571. 444.