Viral Replication Complexes : : Structures, Functions, Applications and Inhibitors / / edited by David D. Boehr.

• TeilnehmendeR: Boehr, David D.,
• Place / Publishing House: Basel : : MDPI,, 2016.; ©2016
• Year of Publication: 2016
• Language: English
• Physical Description: 1 online resource (xvi, 444 pages)

Viruses are obligate intracellular parasites that need to co-opt a living cell's machinery for replication. At the heart of the viral replication machinery are the nucleic acid polymerases, which are responsible for efficiently copying the viral genome. This process must often be coordinated with other viral processes, including protein translation and viral packaging. The polymerases and other components of the replication machinery may serve as potential anti-viral targets. Section 1 of this book is devoted to the basic structure-function relationships of viral nucleic acid polymerases and related proteins. Section 2 then discusses how interactions between the viral polymerase and viral nucleic acids and other proteins help to coordinate nucleic acid synthesis and other important viral processes. Section 3 builds on this discussion by including the roles of host proteins in these processes. Many viruses also co-opt host lipid membranes to provide more conducive environments for RNA synthesis and virus replication, which is discussed in Section 4. Finally, many of the processes discussed in the preceding sections are potential antiviral drug targets, which is discussed in Section 5.

Table of Contents

List of Contributors VII -- About the Guest Editor .XIII -- Preface to "Viral Replication Complexes: Structures, Functions, Applications and Inhibitors" .XV -- Chapter 1: Molecular Perspectives on Virus Replication Proteins -- Cristina Ferrer-Orta, Diego Ferrero and Núria Verdaguer RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory Mechanisms Reprinted from: Viruses 2015, 7(8), 4438-4460 http://www.mdpi.com/1999-4915/7/8/2829 3 -- Ester Sesmero and Ian F. Thorpe Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and Dynamics Reprinted from: Viruses 2015, 7(7), 3974-3994 http://www.mdpi.com/1999-4915/7/7/2808 29 -- Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron and David D. Boehr Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase Reprinted from: Viruses 2015, 7(10), 5571-5586 http://www.mdpi.com/1999-4915/7/10/2894 52 -- Ibrahim M. Moustafa, David W. Gohara, Akira Uchida, Neela Yennawar and Craig E. Cameron Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome? Reprinted from: Viruses 2015, 7(11), 5962-5986 http://www.mdpi.com/1999-4915/7/11/2919 74 -- Chapter 2: Coordinated Interactions of Viral Proteins and Nucleic Acids -- Erin Noble, Michelle M. Spiering and Stephen J. Benkovic Coordinated DNA Replication by the Bacteriophage T4 Replisome Reprinted from: Viruses 2015, 7(6), 3186-3200 http://www.mdpi.com/1999-4915/7/6/2766.111** Jason W. Rausch and Stuart F. J. Le Grice HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective Reprinted from: Viruses 2015, 7(6), 3053-3075 http://www.mdpi.com/1999-4915/7/6/2760.127** Bárbara Rojas-Araya, Théophile Ohlmann and Ricardo Soto-Rifo Translational Control of the HIV Unspliced Genomic RNA Reprinted from: Viruses 2015, 7(8), 4326-4351 http://www.mdpi.com/1999-4915/7/8/2822.153** Valerie J. Klema, Radhakrishnan Padmanabhan and Kyung H. Choi Flaviviral Replication Complex: Coordination between RNA Synthesis and 5'- RNA Capping Reprinted from: Viruses 2015, 7(8), 4640-4656 http://www.mdpi.com/1999-4915/7/8/2837.180** Alexandre Carpentier, Pierre-Yves Barez, Malik Hamaidia, Hélène Gazon, Alix de Brogniez, Srikanth Perike, Nicolas Gillet and Luc Willems Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence Reprinted from: Viruses 2015, 7(7), 3603-3624 http://www.mdpi.com/1999-4915/7/7/2793.198.