Replication-Competent Reporter-Expressing Viruses / / edited by Luis Martinez-Sobrido.

• TeilnehmendeR: Martinez-Sobrido, Luis,
• Place / Publishing House: Basel : : MDPI,, 2016.; ©2016
• Year of Publication: 2016
• Language: English
• Physical Description: 1 online resource (xvi, 322 pages) :; illustrations

Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, tractable replicating-competent, reporter-expressing viruses provide an ideal approach to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-throughput screening settings. In this Special Issue "Replication-Competent Reporter-Expressing Viruses" we review replication-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. We also seek to discuss disadvantages and limitations associated with these reporter-expressing viruses. Finally, we provide rational future perspectives and additional avenues for the development, characterization, and applications of recombinant, reporter-expressing, competent viruses.

Table of Contents

Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker and Richard J. Kuhn -- Ronan N. Rouxel, Emilie Mérour, Stéphane Biacchesi and Michel Brémont -- Yan-Dong Tang, Ji-Ting Liu, Qiong-Qiong Fang, Tong-Yun Wang, Ming-Xia Sun, Tong-Qing An, Zhi-Jun Tian and Xue-Hui Cai -- Jianhui Nie, Yangyang Liu, Weijin Huang and Youchun Wang -- Fumihiro Kato and Takayuki Hishiki -- Yongfeng Li, Lian-Feng Li, Shaoxiong Yu, Xiao Wang, Lingkai Zhang,Jiahui Yu, Libao Xie, Weike Li, Razim Ali and Hua-Ji Qiu -- Weiya Bai, Xiaoxian Cui, Youhua Xie and Jing Liu -- Sally Al Ali, Sara Baldanta, Mercedes Fernández-Escobar and Susana Guerra -- Kristina Maria Schmidt and Elke Mühlberger -- Michael Breen, Aitor Nogales, Steven F. Baker and Luis Martínez-Sobrido -- Cheng-Lin Deng, Si-Qing Liu, Dong-Gen Zhou, Lin-Lin Xu, Xiao-Dan Li, Pan-Tao Zhang, Peng-Hui Li, Han-Qing Ye, Hong-Ping Wei, Zhi-Ming Yuan,Cheng-Feng Qin and Bo Zhang -- Shin-Hee Kim and Siba K. Samal -- Jacques Robert and James K. Jancovich -- Luis Martínez-Sobrido and Juan Carlos de la Torre -- Christina A. Rostad, Michael C. Currier and Martin L. Moore.