Molecular pathways of estrogen receptor action / / edited by Farzad Pakdel.
Estrogen receptors (ERs) are typical members of the superfamily of nuclear receptors that mainly function as ligand-inducible transcription factors that bind chromatin, as homodimers, at specific response elements. A tight reciprocal coupling between rapid 'non-genomic' and 'genomic...
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Place / Publishing House: | Basel, Switzerland : : MDPI,, [2018] ©2018 |
Year of Publication: | 2018 |
Language: | English |
Physical Description: | 1 online resource (304 pages) :; illustrations |
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Molecular pathways of estrogen receptor action / edited by Farzad Pakdel. Basel, Switzerland : MDPI, [2018] ©2018 1 online resource (304 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Description based on publisher supplied metadata and other sources. Estrogen receptors (ERs) are typical members of the superfamily of nuclear receptors that mainly function as ligand-inducible transcription factors that bind chromatin, as homodimers, at specific response elements. A tight reciprocal coupling between rapid 'non-genomic' and 'genomic' ER actions may also occur in many physiological processes. ERs have long been evaluated for their roles in controlling the expression of genes involved in vital cellular processes such as proliferation, apoptosis, and differentiation. Therefore, given the various and pleiotropic functions of ERs, the dysregulation of their pathways contributes to several diseases such as the hormone-dependent breast; endometrial and ovarian cancers; and neurodegenerative diseases, cardiovascular diseases, and osteoporosis. In this printed edition of the Special Issue, "Molecular Pathways of Estrogen Receptor Action", promising results on understanding the mechanisms underlying ER-mediated effects in various pathophysiological processes are represented, covering different roles of ER pathways in the tumorigenesis, the resistance to endocrine therapy, the dynamics of 3D genome organization, and cross-talk with other signaling pathways. This Special Issue also provides insight into the emerging roles of estrogen-signaling pathways in lung cancer, the tumor microenvironment, and the immune system. Includes bibliographical references. Estrogen Receptors. Pakdel, Farzad, editor. |
language |
English |
format |
eBook |
author2 |
Pakdel, Farzad, |
author_facet |
Pakdel, Farzad, |
author2_variant |
f p fp |
author2_role |
TeilnehmendeR |
title |
Molecular pathways of estrogen receptor action / |
spellingShingle |
Molecular pathways of estrogen receptor action / |
title_full |
Molecular pathways of estrogen receptor action / edited by Farzad Pakdel. |
title_fullStr |
Molecular pathways of estrogen receptor action / edited by Farzad Pakdel. |
title_full_unstemmed |
Molecular pathways of estrogen receptor action / edited by Farzad Pakdel. |
title_auth |
Molecular pathways of estrogen receptor action / |
title_new |
Molecular pathways of estrogen receptor action / |
title_sort |
molecular pathways of estrogen receptor action / |
publisher |
MDPI, |
publishDate |
2018 |
physical |
1 online resource (304 pages) : illustrations |
isbn |
3-03897-297-5 |
callnumber-first |
Q - Science |
callnumber-subject |
QP - Physiology |
callnumber-label |
QP572 |
callnumber-sort |
QP 3572 E85 M654 42018 |
illustrated |
Illustrated |
dewey-hundreds |
500 - Science |
dewey-tens |
570 - Life sciences; biology |
dewey-ones |
573 - Specific physiological systems in animals |
dewey-full |
573.44 |
dewey-sort |
3573.44 |
dewey-raw |
573.44 |
dewey-search |
573.44 |
work_keys_str_mv |
AT pakdelfarzad molecularpathwaysofestrogenreceptoraction |
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Molecular pathways of estrogen receptor action / |
author2_original_writing_str_mv |
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