PrPSc prions : : state of the art / / edited by Joaquín Castilla, Jesús R. Requena.

• TeilnehmendeR: Castilla, Joaquín,; Requena, Jesús R.,
• Place / Publishing House: Basel, Switzerland : : MDPI,, [2018]; ©2018
• Year of Publication: 2018
• Language: English
• Physical Description: 1 online resource (210 pages) :; illustrations

Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of fatal and transmissible neurodegenerative disorders characterized by long incubation periods, misfolded prion protein (PrP) deposition, and usually spongiform vacuolation. These devastating diseases affect many mamma...

Table of Contents

• About the Special Issue Editors . vii
• Preface to "PrPSc Prions: State of the Art" . ix
• Daniel Hughes and Mark Halliday What Is Our Current Understanding of PrPSc-Associated Neurotoxicity and Its Molecular Underpinnings? Reprinted from: Pathogens 2017, 6, 63, doi: 10.3390/pathogens6040063 . 1
• Maria Letizia Barreca, Nunzio Iraci, Silvia Biggi, Violetta Cecchetti and Emiliano Biasini Pharmacological Agents Targeting the Cellular Prion Protein Reprinted from: Pathogens 2018, 7, 27, doi: 10.3390/pathogens7010027 . 23
• Jos ´e Miguel Flores-Fern´andez, Vineet Rathod and Holger Wille Comparing the Folds of Prions and Other Pathogenic Amyloids Reprinted from: Pathogens 2018, 7, 50, doi: 10.3390/pathogens7020050 . 39
• Nicholas J. Haley and J ¨urgen A. Richt Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids Reprinted from: Pathogens 2017, 6, 35, doi: 10.3390/pathogens6030035 . 53
• Holger Wille and Jes ´us R. Requena The Structure of PrPSc Prions Reprinted from: Pathogens 2018, 7, 20, doi: 10.3390/pathogens7010020 . 75
• Jian Hu, Holger Wille and Gerold Schmitt-Ulms The Evolutionary unZIPping of a Dimerization Motif-A Comparison of ZIP and PrP Architectures Reprinted from: Pathogens 2018, 7, 4, doi: 10.3390/pathogens7010004 86
• Jorge M. Charco, Hasier Erana, ˜ Vanessa Venegas, Sandra Garc´ıa-Mart´ınez, Rafael Lopez-Moreno, ´ Ezequiel Gonz´alez-Miranda, Miguel Angel ´ P´erez-Castro and Joaqu´ın Castilla Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies Reprinted from: Pathogens 2017, 6, 67, doi: 10.3390/pathogens6040067 . 97
• Neil A. Mabbott How do PrPSc Prions Spread between Host Species, and within Hosts? Reprinted from: Pathogens 2017, 6, 60, doi: 10.3390/pathogens6040060 . 117
• Amber Roguski and Andrew C. Gill The Role of the Mammalian Prion Protein in the Control of Sleep Reprinted from: Pathogens 2017, 6, 58, doi: 10.3390/pathogens6040058 . 158
• Ang ´elique Igel-Egalon, Vincent B´eringue, Human Rezaei and Pierre Sibille Prion Strains and Transmission Barrier Phenomena Reprinted from: Pathogens 2018, 7, 5, doi: 10.3390/pathogens7010005 170.