Human Polyomaviruses and Papillomaviruses / / edited by Ugo Moens.

• TeilnehmendeR: Moens, Ugo,
• Place / Publishing House: Basel, Switzerland : : MDPI,, 2018.
• Year of Publication: 2018
• Language: English
• Physical Description: 1 online resource (196 pages)

The interest in human polyomaviruses (HPyV) has seen a renaissance because of new species that have been isolated and their previously unknown association with diseases. Likewise, the increasing evidence for the association of human papillomaviruses (HPV) with oropharyngeal cancer has sparked the attention of researchers and clinicians. The Special Issue "Human Polyomaviruses and Papillomaviruses" presents studies describing the nuclear egress of BK polyomavirus mediated by the viral agnoprotein and the cellular a-SNAP protein. In addition, a study examines the promoter activity of two different variants of human polyomavirus 9 in different cell lines. This Special Issue offers an interesting perspective on the epidemiology of HR-HPV in different cancers and on the mechanisms by which these viruses target host cell proteins to replicate their genome, express their genes, interfere with autophagy, and induce cancer. Other topics that are highlighted include the role of co-factors, such as smoking and co-infection, novel therapeutic strategies, and surface immunoregulatory proteins, chemokines, and cytokines as possible biomarkers to determine the stage of a tumor and to predict clinical outcomes.

Table of Contents

About the Special Issue Editor vii -- Ugo Moens Human Polyomaviruses and Papillomaviruses Reprinted from: Int. J. Mol. Sci. 2018, 19, 2360, doi: 10.3390/ijms19082360 1 -- Margarita-Maria Panou, Emma L. Prescott, Daniel L. Hurdiss, Gemma Swinscoe, Michael Hollinshead, Laura G. Caller, Ethan L. Morgan, Louisa Carlisle, Marietta M ¨uller, Michelle Antoni, David Kealy, Neil A. Ranson, Colin M. Crump and Andrew Macdonald Agnoprotein Is an Essential Egress Factor during BK Polyomavirus Infection Reprinted from: Int. J. Mol. Sci. 2018, 19, 902, doi: 10.3390/ijms19030902 6 -- Ugo Moens, Xiaobo Song, Marijke Van Ghelue, John A. Lednicky and Bernhard Ehlers A Role of Sp1 Binding Motifs in Basal and Large T-Antigen-Induced Promoter Activities of Human Polyomavirus HPyV9 and Its Variant UF-1 Reprinted from: Int. J. Mol. Sci. 2017, 18, 2414, doi: 10.3390/ijms18112414 22 -- Nicole S. L. Yeo-Teh, Yoshiaki Ito and Sudhakar Jha High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis Reprinted from: Int. J. Mol. Sci. 2018, 19, 1706, doi: 10.3390/ijms19061706 34 -- Kersti Nilsson, Chengjun Wu and Stefan Schwartz Role of the DNA Damage Response in Human Papillomavirus RNA Splicing and Polyadenylation Reprinted from: Int. J. Mol. Sci. 2018, 19, 1735, doi: 10.3390/ijms19061735 61 -- Giovanni Barillari, Paolo Monini, Cecilia Sgadari and Barbara Ensoli The Impact of Human Papilloma Viruses, Matrix Metallo-Proteinases and HIV Protease Inhibitors on the Onset and Progression of Uterine Cervix Epithelial Tumors: A Review of Preclinical and Clinical Studies Reprinted from: Int. J. Mol. Sci. 2018, 19, 1418, doi: 10.3390/ijms19051418 78 -- Domenico Mattoscio, Alessandro Medda and Susanna Chiocca Human Papilloma Virus and Autophagy Reprinted from: Int. J. Mol. Sci. 2018, 19, 1775, doi: 10.3390/ijms19061775 102 -- Anja Lidwina Geßner, Angelika Borkowetz, Michael Baier, Angela G ¨ohlert, Torsten J. Wilhelm, Alexander Thumbs, Eric Borgstein, Lars Jansen, Katrin Beer, Henning Mothes and Matthias D ¨urst Detection of HPV16 in Esophageal Cancer in a High-Incidence Region of Malawi Reprinted from: Int. J. Mol. Sci. 2018, 19, 557, doi: 10.3390/ijms19020557 114 -- Bartłomiej Drop, Małgorzata Strycharz-Dudziak, Ewa Kliszczewska and Małgorzata Polz-Dacewicz Coinfection with Epstein-Barr Virus (EBV), Human Papilloma Virus (HPV) and Polyoma BK Virus (BKPyV) in Laryngeal, Oropharyngeal and Oral Cavity Cancer Reprinted from: Int. J. Mol. Sci. 2017, 18, 2752, doi: 10.3390/ijms18122752 130 -- Kimon Chatzistamatiou, Theodoros Moysiadis, Dimos Vryzas, Ekaterini Chatzaki, Andreas M. Kaufmann, Isabel Koch, Erwin Soutschek, Oliver Boecher, Athena Tsertanidou, Nikolaos Maglaveras, Pidder Jansen-Duerr and Theodoros Agorastos Cigarette Smoking Promotes Infection of Cervical Cells by High-Risk Human Papillomaviruses, but not Subsequent E7 Oncoprotein Expression Reprinted from: Int. J. Mol. Sci. 2018, 19, 422, doi: 10.3390/ijms19020422 143 -- Torbj ¨orn Ramqvist, Anders N¨asman, Bo Franz´en, Cinzia Bersani, Andrey Alexeyenko, Susanne Becker, Linnea Haeggblom, Aeneas Kolev, Tina Dalianis and Eva Munck-Wikland Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome Reprinted from: Int. J. Mol. Sci. 2018, 19, 978, doi: 10.3390/ijms19040978 155 -- Katrin Carow, Mandy G ¨olitz, Maria Wolf, Norman H ¨afner, Lars Jansen, Heike Hoyer, Elisabeth Schwarz, Ingo B. Runnebaum and Matthias D ¨urst Viral-Cellular DNA Junctions as Molecular Markers for Assessing Intra-Tumor Heterogeneity in Cervical Cancer and for the Detection of Circulating Tumor DNA Reprinted from: Int. J. Mol. Sci. 2017, 18, 2032, doi: 10.3390/ijms18102032 172.