Non-Alcoholic Fatty Liver Disease Research 2016 / / edited by Amedeo Lonardo and Giovanni Targher.

• TeilnehmendeR: Lonardo, Amedeo,; Targher, Giovanni,
• Place / Publishing House: Basel : : MDPI,, 2018.; ©2018
• Year of Publication: 2018
• Language: English
• Physical Description: 1 online resource (xi, 566 pages) :; illustrations

This new book entitled "Non-Alcoholic Fatty Liver Disease Research 2016" covers a selection of recent research topics and current review articles in the field of nonalcoholic fatty liver disease (NAFLD) that have been recently published in a monographic Special Issue of the International Journal of Molecular Sciences (IJMS) journal. NAFLD is an "umbrella" definition that encompasses a spectrum of histopathological liver changes ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) with/without fibrosis, "cryptogenic" cirrhosis and hepatocellular carcinoma. NAFLD has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. It is now becoming increasingly clear that the clinical and economic burden of NAFLD does not only affect the liver, but also affects the risk of developing cardiovascular disease, type 2 diabetes mellitus, colo-rectal neoplasms, chronic kidney disease and other extra-hepatic diseases that have a considerable impact on health-care expenditures. Against this background, further research is needed to better understand the natural history, and the molecular pathogenesis of NAFLD, as well as to elucidate the underlying mechanisms by which NAFLD contributes to the increased cardiometabolic risk, and to disclose novel and effective treatment strategies for this increasingly prevalent and burdensome disease. Some of the leading international researchers in this area expressed a willingness to contribute to this book providing an updated, state-of-the-art view on the aforementioned topics, and also suggesting novel research avenues for NAFLD.

Table of Contents

About the Special Issue Editors . ix -- Preface to "Non-Alcoholic Fatty Liver Disease Research 2016" . xi -- Amedeo Lonardo and Giovanni Targher NAFLD: Is There Anything New under the Sun? Reprinted from: Int. J. Mol. Sci. 2017, 18, 1955, doi: 10.3390/ijms18091955 1 -- Alexandre Losekann, Antonio C. Weston, Angelo A. de Mattos, Cristiane V. Tovo, Luis A. de Carli, Marilia B. Espindola, Sergio R. Pioner and Gabriela P. Coral Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients Reprinted from: Int. J. Mol. Sci. 2015, 16, 25552-25559, doi: 10.3390/ijms161025552 13 -- Rosa Lombardi, Giuseppina Pisano and Silvia Fargion Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD Reprinted from: Int. J. Mol. Sci. 2016, 17, 548, doi: 10.3390/ijms17040548 19 -- Francesco Baratta, Daniele Pastori, Licia Polimeni, Giulia Tozzi, Francesco Violi, Francesco Angelico and Maria Del Ben Does Lysosomial Acid Lipase Reduction Play a Role in Adult Non-Alcoholic Fatty Liver Disease? Reprinted from: Int. J. Mol. Sci. 2015, 16, 28014-28021, doi: 10.3390/ijms161226085 34 -- Eyal Shteyer, Rivka Villenchik, Mahmud Mahamid, Nidaa Nator and Rifaat Safadi Low Serum Lysosomal Acid Lipase Activity Correlates with Advanced Liver Disease Reprinted from: Int. J. Mol. Sci. 2016, 17, 312, doi: 10.3390/ijms17030312 42 -- Elizabeth M. Brunt Nonalcoholic Fatty Liver Disease: Pros and Cons of Histologic Systems of Evaluation Reprinted from: Int. J. Mol. Sci. 2016, 17, 97, doi: 10.3390/ijms17010097 . 52 -- Benedetta Donati and Luca Valenti Telomeres, NAFLD and Chronic Liver Disease Reprinted from: Int. J. Mol. Sci. 2016, 17, 383, doi: 10.3390/ijms17030383 62 -- Linda A. Ban, Nicholas A. Shackel and Susan V. McLennan Extracellular Vesicles: A New Frontier in Biomarker Discovery for Non-Alcoholic Fatty Liver Disease Reprinted from: Int. J. Mol. Sci. 2016, 17, 376, doi: 10.3390/ijms17030376 75 -- Natalia Nu ˜no-L ´ambarri, Varenka J. Barbero-Becerra, Misael Uribe and Norberto C. Ch ´avez-Tapia Mitochondrial Molecular Pathophysiology of Nonalcoholic Fatty Liver Disease: A Proteomics Approach Reprinted from: Int. J. Mol. Sci. 2016, 17, 281, doi: 10.3390/ijms17030281 89 -- Roberto Gambino, Elisabetta Bugianesi, Chiara Rosso, Lavinia Mezzabotta, Silvia Pinach, Natalina Alemanno, Francesca Saba and Maurizio Cassader Different Serum Free Fatty Acid Profiles in NAFLD Subjects and Healthy Controls after Oral Fat Load Reprinted from: Int. J. Mol. Sci. 2016, 17, 479, doi: 10.3390/ijms17040479 101 -- David Houghton, Christopher J. Stewart, Christopher P. Day and Michael Trenell Gut Microbiota and Lifestyle Interventions in NAFLD Reprinted from: Int. J. Mol. Sci. 2016, 17, 447, doi: 10.3390/ijms17040447 116 -- Mariana Verdelho Machado and Helena Cortez-Pinto Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet Reprinted from: Int. J. Mol. Sci. 2016, 17, 481, doi: 10.3390/ijms17040481 145 -- Gemma Aragon`es, Teresa Auguet, Sandra Armengol, Alba Berlanga, Esther Guiu-Jurado, Carmen Aguilar, Salom´e Mart´ınez, F ´atima Sabench, Jos´e Antonio Porras, Maikel Daniel Ruiz, Merc´e Hern ´andez, Joan Josep Sirvent, Daniel Del Castillo and Crist ´obal Richart PNPLA3 Expression Is Related to Liver Steatosis in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease Reprinted from: Int. J. Mol. Sci. 2016, 17, 630, doi: 10.3390/ijms17050630 165 -- Elina M. Pet ¨aj ¨a and Hannele Yki-J ¨arvinen Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD-A Systematic Review Reprinted from: Int. J. Mol. Sci. 2016, 17, 633, doi: 10.3390/ijms17050633 178 -- Giuseppina Pisano, Rosa Lombardi and Anna Ludovica Fracanzani Vascular Damage in Patients with Nonalcoholic Fatty Liver Disease: Possible Role of Iron and Ferritin Reprinted from: Int. J. Mol. Sci. 2016, 17, 675, doi: 10.3390/ijms17050675 194 -- Mariana Verdelho Machado and Anna Mae Diehl Role of Hedgehog Signaling Pathway in NASH Reprinted from: Int. J. Mol. Sci. 2016, 17, 857, doi: 10.3390/ijms17060857 206 -- Alessandra Caligiuri, Alessandra Gentilini and Fabio Marra Molecular Pathogenesis of NASH Reprinted from: Int. J. Mol. Sci. 2016, 17, 1575, doi: 10.3390/ijms17091575 219 -- Michael France, See Kwok, Handrean Soran, Steve Williams, Jan Hoong Ho, Safwaan Adam, Dexter Canoy, Yifen Liu and Paul N. Durrington Liver Fat Measured by MR Spectroscopy: Estimate of Imprecision and Relationship with Serum Glycerol, Caeruloplasmin and Non-Esterified Fatty Acids Reprinted from: Int. J. Mol. Sci. 2016, 17, 1089, doi: 10.3390/ijms17071089 253 -- Salvatore Petta, Amalia Gastaldelli, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti and Ferruccio Bonino Pathophysiology of Non Alcoholic Fatty Liver Disease Reprinted from: Int. J. Mol. Sci. 2016, 17, 2082, doi: 10.3390/ijms17122082 261 -- Alessandro Mantovani, Paolo Gisondi, Amedeo Lonardo and Giovanni Targher Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis? Reprinted from: Int. J. Mol. Sci. 2016, 17, 217, doi: 10.3390/ijms17020217 287 -- Patrick Wainwright and Christopher D. Byrne Bidirectional Relationships and Disconnects between NAFLD and Features of the Metabolic Syndrome Reprinted from: Int. J. Mol. Sci. 2016, 17, 367, doi: 10.3390/ijms17030367 300 -- Stefano Ballestri, Fabio Nascimbeni, Dante Romagnoli, Enrica Baldelli, Giovanni Targher and Amedeo Lonardo Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection-Liver: The "Musketeer" in the Spotlight Reprinted from: Int. J. Mol. Sci. 2016, 17, 355, doi: 10.3390/ijms17030355 317 -- Maria Perticone, Antonio Cimellaro, Raffaele Maio, Benedetto Caroleo, Angela Sciacqua, Giorgio Sesti and Francesco Perticone Additive Effect of Non-Alcoholic Fatty Liver Disease on Metabolic Syndrome-Related Endothelial Dysfunction in Hypertensive Patients Reprinted from: Int. J. Mol. Sci. 2016, 17, 456, doi: 10.3390/ijms17040456 342 -- Morgan Marcuccilli and Michel Chonchol NAFLD and Chronic Kidney Disease Reprinted from: Int. J. Mol. Sci. 2016, 17, 562, doi: 10.3390/ijms17040562 353 -- Cristiane A. Villela-Nogueira, Nathalie C. Leite, Claudia R. L. Cardoso and Gil F. Salles NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms? Reprinted from: Int. J. Mol. Sci. 2016, 17, 460, doi: 10.3390/ijms17040460 367 -- Claudia Sanna, Chiara Rosso, Milena Marietti and Elisabetta Bugianesi Non-Alcoholic Fatty Liver Disease and Extra-Hepatic Cancers Reprinted from: Int. J. Mol. Sci. 2016, 17, 717, doi: 10.3390/ijms17050717 380 -- Luis Calzadilla Bertot and Leon Anton Adams The Natural Course of Non-Alcoholic Fatty Liver Disease Reprinted from: Int. J. Mol. Sci. 2016, 17, 774, doi: 10.3390/ijms17050774 394 -- Stefano Gitto and Erica Villa Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome after Liver Transplant Reprinted from: Int. J. Mol. Sci. 2016, 17, 490, doi: 10.3390/ijms17040490 407 -- Jonathan L. Temple, Paul Cordero, Jiawei Li, Vi Nguyen and Jude A. Oben A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence Reprinted from: Int. J. Mol. Sci. 2016, 17, 947, doi: 10.3390/ijms17060947 418 -- Lucia Pacifico, Enea Bonci, Gian Marco Andreoli, Michele Di Martino, Alessia Gallozzi, Ester De Luca and Claudio Chiesa The Impact of Nonalcoholic Fatty Liver Disease on Renal Function in Children with Overweight/Obesity Reprinted from: Int. J. Mol. Sci. 2016, 17, 1218, doi: 10.3390/ijms17081218 455 -- Luigi Elio Adinolfi, Luca Rinaldi, Barbara Guerrera, Luciano Restivo, Aldo Marrone, Mauro Giordano and Rosa Zampino NAFLD and NASH in HCV Infection: Prevalence and Significance in Hepatic and Extrahepatic Manifestations Reprinted from: Int. J. Mol. Sci.

2016, 17, 803, doi: 10.3390/ijms17060803 464 -- Ryuta Shigefuku, Hideaki Takahashi, Hiroyasu Nakano, Tsunamasa Watanabe, Kotaro Matsunaga, Nobuyuki Matsumoto, Masaki Kato, Ryo Morita, Yousuke Michikawa, Tomohiro Tamura, Tetsuya Hiraishi, Nobuhiro Hattori, Yohei Noguchi, Kazunari Nakahara, Hiroki Ikeda, Toshiya Ishii, Chiaki Okuse, Shigeru Sase, Fumio Itoh and Michihiro Suzuki Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus Reprinted from: Int. J. Mol. Sci.

2016, 17, 1545, doi: 10.3390/ijms17091545 476 -- Ewa Stachowska, Karina Ryterska, Dominika Maciejewska, Marcin Banaszczak, Piotr Milkiewicz, Małgorzata Milkiewicz, Izabela Gutowska, Piotr Ossowski, Małgorzata Kaczorowska, Dominika Jamioł-Milc, Anna Sabinicz, Małgorzata Napierała, Lidia Wadołowska and Joanna Raszeja-Wyszomirska Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR) Reprinted from: Int. J. Mol. Sci. 2016, 17, 1192, doi: 10.3390/ijms17071192 492 -- Maria Catalina Hernandez-Rodas, Rodrigo Valenzuela and Luis A. Videla Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease Reprinted from: Int. J. Mol. Sci. 2015, 16, 25168-25198, doi: 10.3390/ijms161025168 506 -- Sofie M. A. Walenbergh, Tom Houben, Tim Hendrikx, Mike L. J. Jeurissen, Patrick J. van Gorp, Nathalie Vaes, Steven W. M. Olde Damink, Fons Verheyen, Ger H. Koek, Dieter L ¨utjohann, Alena Grebe, Eicke Latz and Ronit Shiri-Sverdlov Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice Reprinted from: Int. J. Mol. Sci. 2015, 16, 21056-21069, doi: 10.3390/ijms160921056 530 -- Takayasu Ideta, Yohei Shirakami, Tsuneyuki Miyazaki, Takahiro Kochi, Hiroyasu Sakai, Hisataka Moriwaki and Masahito Shimizu The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice Reprinted from: Int. J. Mol. Sci. 2015, 16, 29207-29218, doi: 10.3390/ijms161226156 541.