Model systems in biology : : history, philosophy, and practical concerns / / Georg Striedter.
"Instead of arguing for a specific animal model, Striedter will review the history and philosophy of animal models in biomedical research, examining their various advantages and limitations"--
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Superior document: | The MIT Press |
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Place / Publishing House: | Cambridge, Massachusetts : : The MIT Press,, [2022] |
Year of Publication: | 2022 |
Edition: | 1st ed. |
Language: | English |
Series: | The MIT Press
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Physical Description: | 1 online resource (303 pages) |
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Table of Contents:
- Intro
- Contents
- Preface
- 1. Crises in Biomedical Research
- 1.1 The Translatability Crisis
- 1.2 The Replicability Crisis
- 1.3 Reckoning with Biological Variation
- 1.4 Which Model Is "Best"?
- 1.5 This Book's Approach and Organization
- 2. Philosophy of Models in Biology
- 2.1 Abstract Models
- 2.2 Material Models
- 2.3 Assumptions about Model Fidelity
- 2.4 Dealing with Biological Complexity
- 2.5 Animal Welfare and Cognitive Dissonance
- 2.6 Comparative Biology and August Krogh Revisited
- 3. A History of Animal Models
- 3.1 Eclectic Beginnings of Biology
- 3.2 Early Experimental Medicine: Research on Pet Species
- 3.3 Fruit Flies: The First Supermodel
- 3.4 Laboratory Rats: The First Standardized Mammals
- 3.5 Laboratory Mice: From Cancer Fighter to Model Organism
- 3.6 Nonhuman Primates
- 3.7 The Rest of the Menagerie
- 3.8 Model System Ecology
- 4. A History of in Vitro Models
- 4.1 Microbial Models
- 4.2 Cell and Tissue Culture Models
- 4.3 Alternative Models in Toxicology
- 4.4 Model Ecology Revisited
- 5. Models and Therapies: Infectious Diseases, Cardiovascular Disease, and Cancer
- 5.1 Infectious Diseases
- 5.2 Cardiovascular Diseases
- 5.3 Cancers
- 5.4 Patterns of Model Use
- 6. Neurological Disorders: Trials and Tribulations
- 6.1 Brain and Spinal Cord Injuries
- 6.2 Neurodegenerative Disorders
- 6.3 Neuropsychiatric Disorders
- 6.4 Successes, Failures, Hopes
- 7. Diagnosis and Recommendations
- 7.1 Four Perspectives on Models in Biology
- 7.2 Recommendations
- 7.3 Conclusion
- Appendix
- References
- Index.