Model systems in biology : : history, philosophy, and practical concerns / / Georg Striedter.

• Superior document: The MIT Press
• VerfasserIn: Striedter, Georg F., 1962-
• Place / Publishing House: Cambridge, Massachusetts : : The MIT Press,, [2022]
• Year of Publication: 2022
• Edition: 1st ed.
• Language: English
• Series: The MIT Press
• Physical Description: 1 online resource (303 pages)

"Instead of arguing for a specific animal model, Striedter will review the history and philosophy of animal models in biomedical research, examining their various advantages and limitations"--

Table of Contents

• Intro
• Contents
• Preface
• 1. Crises in Biomedical Research
• 1.1 The Translatability Crisis
• 1.2 The Replicability Crisis
• 1.3 Reckoning with Biological Variation
• 1.4 Which Model Is "Best"?
• 1.5 This Book's Approach and Organization
• 2. Philosophy of Models in Biology
• 2.1 Abstract Models
• 2.2 Material Models
• 2.3 Assumptions about Model Fidelity
• 2.4 Dealing with Biological Complexity
• 2.5 Animal Welfare and Cognitive Dissonance
• 2.6 Comparative Biology and August Krogh Revisited
• 3. A History of Animal Models
• 3.1 Eclectic Beginnings of Biology
• 3.2 Early Experimental Medicine: Research on Pet Species
• 3.3 Fruit Flies: The First Supermodel
• 3.4 Laboratory Rats: The First Standardized Mammals
• 3.5 Laboratory Mice: From Cancer Fighter to Model Organism
• 3.6 Nonhuman Primates
• 3.7 The Rest of the Menagerie
• 3.8 Model System Ecology
• 4. A History of in Vitro Models
• 4.1 Microbial Models
• 4.2 Cell and Tissue Culture Models
• 4.3 Alternative Models in Toxicology
• 4.4 Model Ecology Revisited
• 5. Models and Therapies: Infectious Diseases, Cardiovascular Disease, and Cancer
• 5.1 Infectious Diseases
• 5.2 Cardiovascular Diseases
• 5.3 Cancers
• 5.4 Patterns of Model Use
• 6. Neurological Disorders: Trials and Tribulations
• 6.1 Brain and Spinal Cord Injuries
• 6.2 Neurodegenerative Disorders
• 6.3 Neuropsychiatric Disorders
• 6.4 Successes, Failures, Hopes
• 7. Diagnosis and Recommendations
• 7.1 Four Perspectives on Models in Biology
• 7.2 Recommendations
• 7.3 Conclusion
• Appendix
• References
• Index.